Early IL-10 producing B-cells and coinciding Th/Tr17 shifts during three year grass-pollen AITResearch in context

Autor: Ulrich M. Zissler, Constanze A. Jakwerth, Ferdinand M. Guerth, Lisa Pechtold, Juan Antonio Aguilar-Pimentel, Katharina Dietz, Kathrin Suttner, Guido Piontek, Bernhard Haller, Zuzana Hajdu, Matthias Schiemann, Carsten B. Schmidt-Weber, Adam M. Chaker

Publikováno v: EBioMedicine, Vol 36, Iss , Pp 475-488 (2018)

Background: Allergen-specific immunotherapy (AIT) is a causative treatment in allergic airway disease, comprising long-term allergen administration and requiring three years of treatment. Mechanisms and biomarkers that translate into clinical efficac

Externí odkaz: https://doaj.org/article/8745664df04b40409aa0082b5e9a8c7a

Interleukin-4 and interferon-γ orchestrate an epithelial polarization in the airways

Autor: H Heine, M Regn, R Effner, Katharina Dietz, Adam Chaker, Ulrich M. Zissler, Kathrin Suttner, Carsten B. Schmidt-Weber, B Knapp, Fabian J. Theis, Ferdinand Guerth, Guido Piontek, Moritz Ulrich

Publikováno v: Mucosal Immunol. 9, 917-926 (2016)

Interferon-γ (IFN-γ) and interleukin-4 (IL-4) are key effector cytokines for the differentiation of T helper type 1 and 2 (Th1 and Th2) cells. Both cytokines induce fate-decisive transcription factors such as GATA3 and TBX21 that antagonize the pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad28f70731ccf3a59da177df3ffdd2e4
https://doi.org/10.1038/mi.2015.110

Doublesex and Mab-3 Related Transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages

Autor: Burkhard Simma, Simone Lipinski, John Henderson, Andrea von Berg, Omer Kalayci, Thomas Illig, Erik Melén, Jan P. Schouten, Sven Michel, Judith M. Vonk, Umit Murat Sahiner, Michael Kabesch, Kathrin Suttner, Otto Laub, Maxim B. Freidin, Jon Genuneit, Andre Franke, Vincent D. Gaertner, Michael Klintschar, Danny Jonigk, Maximilian Schieck, Albrecht Bufe, Ernst Rietschel, Andrea Heinzmann, Wim Timens, Antoaneta A. Toncheva, Dirkje S. Postma, Raquel Granell, Esra Birben, Bert Brunekreef, Gerard H. Koppelman, G Pershagen, Ludmila M. Ogorodova, Henriette A. Smit, Christian Vogelberg, H. Marike Boezen

Publikováno v: J. Allergy Clin. Immunol. 138, 421-431 (2016)
Journal of Allergy and Clinical Immunology, 138(2), 421-431. MOSBY-ELSEVIER
Schieck, M, Granell, R & Kabesch, M 2016, ' Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages ', Journal of Allergy and Clinical Immunology, vol. 138, no. 2, pp. 421-431 . https://doi.org/10.1016/j.jaci.2015.12.1305
Journal of Allergy and Clinical Immunology, 138(2), 421. Mosby Inc.

BackgroundAsthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific differences are not yet understood.ObjectiveWe analyzed whether and how genetic factors contribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666f7ef0cd22c1a8265418f8688d2906
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=47975

Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk

Autor: Thomas Illig, Norman Klopp, Michael Kabesch, Tim Sparwasser, Martin Wetzke, Kathrin Suttner, Erika von Mutius, Martin Depner

Publikováno v: Journal of Allergy and Clinical Immunology. 125:1395-1399

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425896c4ea014728d10160bd3f00d819
https://doi.org/10.1016/j.jaci.2010.02.017

A Combined Omics Approach to Generate the Surface Atlas of Human Naive CD4+ T Cells during Early T-Cell Receptor Activation

Autor: Herwig Koppensteiner, Michael Schindler, Carsten B. Schmidt-Weber, Anke Graessel, Linda Krause, Edda Kloppmann, Kathrin Suttner, Stefanie M. Hauck, Katharina Dietz, Bettina Knapp, Tatyana Goldberg, Christine von Toerne

Publikováno v: Mol. Cell. Proteomics 14, 2085-2102 (2015)

Naive CD4(+) T cells are the common precursors of multiple effector and memory T-cell subsets and possess a high plasticity in terms of differentiation potential. This stem-cell-like character is important for cell therapies aiming at regeneration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cc946b163c3f1d0d2414a94da55c1b
https://pubmed.ncbi.nlm.nih.gov/25991687