Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kathrin Schönberg"'
Autor:
Maryam Hejazi, Angela R. Manser, Julia Fröbel, Andrea Kündgen, Xiaoyi Zhao, Kathrin Schönberg, Ulrich Germing, Rainer Haas, Norbert Gattermann, Markus Uhrberg
Publikováno v:
Haematologica, Vol 100, Iss 5 (2015)
Natural killer cells are well known to mediate anti-leukemic responses in myeloid leukemia but their role in myelodysplastic syndromes is not well understood. Here, in a cohort of newly diagnosed patients (n=75), widespread structural and functional
Externí odkaz:
https://doaj.org/article/9b6d068e30ee42048109f3eb705c9a06
Supplementary Figure S2 from JAK Inhibition Impairs NK Cell Function in Myeloproliferative Neoplasms
Autor:
Dominik Wolf, Annkristin Heine, Peter Brossart, Tim H. Brümmendorf, Steffen Koschmieder, Walter Verbeek, Markus Uhrberg, Angela R. Manser, Maryam Hejazi, Isabelle Cornez, Sowmya Parampalli Yajnanarayana, Maria Vonnahme, Janna Rudolph, Kathrin Schönberg
Supplementary Figure S2. Phosphorylation levels of JAK1 and JAK3 were not affected by ruxolitinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d408e0a8c5b9b4134b746689c35fc7
https://doi.org/10.1158/0008-5472.22405632.v1
https://doi.org/10.1158/0008-5472.22405632.v1
Autor:
Dominik Wolf, Annkristin Heine, Peter Brossart, Tim H. Brümmendorf, Steffen Koschmieder, Walter Verbeek, Markus Uhrberg, Angela R. Manser, Maryam Hejazi, Isabelle Cornez, Sowmya Parampalli Yajnanarayana, Maria Vonnahme, Janna Rudolph, Kathrin Schönberg
Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e146ce70599bb1528ad1b535581c041
https://doi.org/10.1158/0008-5472.22405641
https://doi.org/10.1158/0008-5472.22405641
Autor:
Tim H. Brümmendorf, Peter Brossart, Kathrin Schönberg, Dominik Wolf, Sowmya Parampalli Yajnanarayana, Walter Verbeek, Steffen Koschmieder, Angela R. Manser, Janna Rudolph, Maria Vonnahme, Maryam Hejazi, Annkristin Heine, Markus Uhrberg, Isabelle Cornez
Publikováno v:
Cancer Research. 75:2187-2199
Ruxolitinib is a small-molecule inhibitor of the JAK kinases, which has been approved for the treatment of myelofibrosis, a rare myeloproliferative neoplasm (MPN), but clinical trials are also being conducted in inflammatory-driven solid tumors. Incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e5fbd68c7809e1f32dc18a14a90323
https://doi.org/10.1158/0008-5472.can-14-3198
https://doi.org/10.1158/0008-5472.can-14-3198
Autor:
Andrea Kündgen, Xiaoyi Zhao, Kathrin Schönberg, Angela R. Manser, Markus Uhrberg, Julia Fröbel, Maryam Hejazi, Norbert Gattermann, Ulrich Germing, Rainer Haas
Publikováno v:
Haematologica. 100:643-652
Natural killer cells are well known to mediate anti-leukemic responses in myeloid leukemia but their role in myelodysplastic syndromes is not well understood. Here, in a cohort of newly diagnosed patients (n=75), widespread structural and functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7b57e10af8cd4d6c961eddb5e8be1a
https://doi.org/10.3324/haematol.2014.118679
https://doi.org/10.3324/haematol.2014.118679
Autor:
Jürgen Finke, Kathrin Schönberg, Markus Kaymer, Christian Schulz-Huotari, Markus Uhrberg, Sabine Glatzel, Marie Follo, Hendrik Veelken, Silvia Rathmann, Paul Fisch
Publikováno v:
Biology of Blood and Marrow Transplantation. 16(4):469-481
The prognosis after hematopoietic cell transplantation (HCT) for the treatment of leukemia or lymphoma in humans is influenced by donor-derived natural killer (NK) cells, which enhance the graft-versus-leukemia (GVL) effect. Such alloreactive killer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342576462fe9820870b36c1225faa1dc
Publikováno v:
Oncoscience
NK cells are innate immune effector cells recognizing and killing virus-infected or malignant cells [1]. NK cell function is tightly regulated by a complex balance between various activating and inhibitory NK cell receptors. In addition, several cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80e89c0ce342c0419680c70c0d7f66e
https://pubmed.ncbi.nlm.nih.gov/26425655
https://pubmed.ncbi.nlm.nih.gov/26425655
Publikováno v:
Oncoimmunology. 5(2)
JAK inhibitors are approved for myelofibrosis (MF) and polycythemia vera (PV), as they reverse inflammation-associated splenomegaly and symptoms. Notably, JAK inhibitors only marginally affect disease burden. The anti-inflammatory effects of JAK inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415ae503e169505ca43623ed8e42c4bb
https://pubmed.ncbi.nlm.nih.gov/27057437
https://pubmed.ncbi.nlm.nih.gov/27057437
Autor:
Dominik Wolf, Peter Brossart, Annkristin Heine, Kathrin Schönberg, Anika Beckers, Stefanie Andrea Erika Held, Anne Ruth Kesper
Immune effector cells such as T and NK cells can efficiently eliminate tumor cells. However, when activating oncogenic signaling pathways or protective mechanisms against cell death are active, immune cells can also confer therapy resistance. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997f6f40bf4d82a7b40761326463c2eb
https://europepmc.org/articles/PMC4760295/
https://europepmc.org/articles/PMC4760295/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 903
Natural killer (NK) cells provide a first line of defense against viral infections and prepare the ground for subsequent action of virus-specific T cells in a concerted way. Human NK cells use a sophisticated system of inhibitory and stimulatory rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9235c10efc1279fd3feb346836b8b6d7
https://pubmed.ncbi.nlm.nih.gov/22782833
https://pubmed.ncbi.nlm.nih.gov/22782833