Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Kathrin Saar"'
Autor:
Märit Jensen, Christian Müller, Norbert Hübner, Giannino Patone, Kathrin Saar, Chi-un Choe, Edzard Schwedhelm, Tanja Zeller
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In humans and mice, L-arginine:glycine amidinotransferase (AGAT) and its metabolites homoarginine (hArg) and creatine have been linked to cardiovascular disease (CVD), specifically myocardial infarction (MI) and heart failure (HF). The under
Externí odkaz:
https://doaj.org/article/a9273e9f4b7046edbda67f802e5685de
Autor:
Kami Pekayvaz, Alexander Leunig, Rainer Kaiser, Markus Joppich, Sophia Brambs, Aleksandar Janjic, Oliver Popp, Daniel Nixdorf, Valeria Fumagalli, Nora Schmidt, Vivien Polewka, Afra Anjum, Viktoria Knottenberg, Luke Eivers, Lucas E. Wange, Christoph Gold, Marieluise Kirchner, Maximilian Muenchhoff, Johannes C. Hellmuth, Clemens Scherer, Raquel Rubio-Acero, Tabea Eser, Flora Deák, Kerstin Puchinger, Niklas Kuhl, Andreas Linder, Kathrin Saar, Lukas Tomas, Christian Schulz, Andreas Wieser, Wolfgang Enard, Inge Kroidl, Christof Geldmacher, Michael von Bergwelt-Baildon, Oliver T. Keppler, Mathias Munschauer, Matteo Iannacone, Ralf Zimmer, Philipp Mertins, Norbert Hubner, Michael Hoelscher, Steffen Massberg, Konstantin Stark, Leo Nicolai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Infection with SARS-COV-2 can result in self-limited upper airway infection or progress to a more systemic inflammatory condition including pneumonic COVID-19. Here the authors utilise a multi-omics approach to interrogate the immune response of pati
Externí odkaz:
https://doaj.org/article/25f8c8382ab44535bbd9a714a216c8f8
Autor:
Rainer Kaiser, Alexander Leunig, Kami Pekayvaz, Oliver Popp, Markus Joppich, Vivien Polewka, Raphael Escaig, Afra Anjum, Marie-Louise Hoffknecht, Christoph Gold, Sophia Brambs, Anouk Engel, Sven Stockhausen, Viktoria Knottenberg, Anna Titova, Mohamed Haji, Clemens Scherer, Maximilian Muenchhoff, Johannes C. Hellmuth, Kathrin Saar, Benjamin Schubert, Anne Hilgendorff, Christian Schulz, Stefan Kääb, Ralf Zimmer, Norbert Hübner, Steffen Massberg, Philipp Mertins, Leo Nicolai, Konstantin Stark
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Neutrophils provide a critical line of defense in immune responses to various pathogens, inflicting self-damage upon transition to a hyperactivated, procoagulant state. Recent work has highlighted proinflammatory neutrophil phenotypes contributing to
Externí odkaz:
https://doaj.org/article/6c76effe0be0417985fb0f08c49e4b8c
Autor:
Herbert Schulz, Dorothea Dietrichs, Markus Wehland, Thomas J. Corydon, Ruth Hemmersbach, Christian Liemersdorf, Daniela Melnik, Norbert Hübner, Kathrin Saar, Manfred Infanger, Daniela Grimm
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7876 (2022)
The high mortality in men with metastatic prostate cancer (PC) establishes the need for diagnostic optimization by new biomarkers. Mindful of the effect of real microgravity on metabolic pathways of carcinogenesis, we attended a parabolic flight (PF)
Externí odkaz:
https://doaj.org/article/3dd636e66eb24ad5bae779f523aa257b
Autor:
Ronald Lützenberg, Kendrick Solano, Christoph Buken, Jayashree Sahana, Stefan Riwaldt, Sascha Kopp, Marcus Krüger, Herbert Schulz, Kathrin Saar, Norbert Huebner, Ruth Hemmersbach, Johann Bauer, Manfred Infanger, Daniela Grimm, Markus Wehland
Publikováno v:
Cellular Physiology and Biochemistry, Vol 47, Iss 4, Pp 1729-1741 (2018)
Background/Aims: Spaceflight negatively influences the function of cartilage tissue in vivo. In vitro human chondrocytes exhibit an altered gene expression of inflammation markers after a two-hour exposure to vibration. Little is known about the impa
Externí odkaz:
https://doaj.org/article/bba56aec2bfb48659cc0f0a7ee17cd7d
Autor:
Sascha Kopp, Jayashree Sahana, Tawhidul Islam, Asbjørn Graver Petersen, Johann Bauer, Thomas J. Corydon, Herbert Schulz, Kathrin Saar, Norbert Huebner, Lasse Slumstrup, Stefan Riwaldt, Markus Wehland, Manfred Infanger, Ronald Luetzenberg, Daniela Grimm
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Human MCF-7 breast cancer cells were exposed to a Random Positioning Machine (RPM). After 24 hours (h) the cells grew either adherently within a monolayer (AD) or within multicellular spheroids (MCS). AD and MCS populations were separately h
Externí odkaz:
https://doaj.org/article/4792f639a36f4440a59f0c9fd262c315
Autor:
Katrīna D. Neiburga, Baiba Vilne, Sabine Bauer, Dario Bongiovanni, Tilman Ziegler, Mark Lachmann, Simon Wengert, Johann S. Hawe, Ulrich Güldener, Annie M. Westerlund, Ling Li, Shichao Pang, Chuhua Yang, Kathrin Saar, Norbert Huebner, Lars Maegdefessel, DigiMed Bayern Consortium, Rüdiger Lange, Markus Krane, Heribert Schunkert, Moritz von Scheidt
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1683 (2021)
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data
Externí odkaz:
https://doaj.org/article/461fbf4139ca4d3e9c7585eb265c814c
Autor:
Jeanie K Meckes, Patrick H Lim, Stephanie L Wert, Wendy Luo, Stephanie A Gacek, Dana Platt, Ryan Jankord, Kathrin Saar, Eva E Redei
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194293 (2018)
Acute stress responsiveness is a quantitative trait that varies in severity from one individual to another; however, the genetic component underlying the individual variation is largely unknown. Fischer 344 (F344) and Wistar Kyoto (WKY) rat strains s
Externí odkaz:
https://doaj.org/article/0c81cc31d21047ad8b0f0da3ce35a870
Autor:
Eva Seemanova, Raymonda Varon, Jan Vejvalka, Petr Jarolim, Pavel Seeman, Krystyna H Chrzanowska, Martin Digweed, Igor Resnick, Ivo Kremensky, Kathrin Saar, Katrin Hoffmann, Véronique Dutrannoy, Mohsen Karbasiyan, Mehdi Ghani, Ivo Barić, Mustafa Tekin, Peter Kovacs, Michael Krawczak, André Reis, Karl Sperling, Michael Nothnagel
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167984 (2016)
The vast majority of patients with Nijmegen Breakage Syndrome (NBS) are of Slavic origin and carry a deleterious deletion (c.657del5; rs587776650) in the NBN gene on chromosome 8q21. This mutation is essentially confined to Slavic populations and may
Externí odkaz:
https://doaj.org/article/d422692967694a85bee0fb44721c5434
Autor:
Claudia Langhans, Steffen Weber-Carstens, Franziska Schmidt, Jida Hamati, Melanie Kny, Xiaoxi Zhu, Tobias Wollersheim, Susanne Koch, Martin Krebs, Herbert Schulz, Doerte Lodka, Kathrin Saar, Siegfried Labeit, Claudia Spies, Norbert Hubner, Joachim Spranger, Simone Spuler, Michael Boschmann, Gunnar Dittmar, Gillian Butler-Browne, Vincent Mouly, Jens Fielitz
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92048 (2014)
ObjectivesSystemic inflammation is a major risk factor for critical-illness myopathy (CIM) but its pathogenic role in muscle is uncertain. We observed that interleukin 6 (IL-6) and serum amyloid A1 (SAA1) expression was upregulated in muscle of criti
Externí odkaz:
https://doaj.org/article/cf7eaf06922144069334d2915c85c5a8