Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kathrin Olschok"'
Autor:
Jessica E. Pritchard, Juliette E. Pearce, Inge A.M. Snoeren, Stijn N.R. Fuchs, Katrin Götz, Fabian Peisker, Silke Wagner, Adam Benabid, Niklas Lutterbach, Vanessa Klöker, James S. Nagai, Monica T. Hannani, Anna K. Galyga, Ellen Sistemich, Bella Banjanin, Niclas Flosdorf, Eric Bindels, Kathrin Olschok, Katharina Biaesch, Nicolas Chatain, Neha Bhagwat, Andrew Dunbar, Rita Sarkis, Olaia Naveiras, Marie-Luise Berres, Steffen Koschmieder, Ross L. Levine, Ivan G. Costa, Hélène F.E. Gleitz, Rafael Kramann, Rebekka K. Schneider
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113608- (2024)
Summary: The role of hematopoietic Hedgehog signaling in myeloproliferative neoplasms (MPNs) remains incompletely understood despite data suggesting that Hedgehog (Hh) pathway inhibitors have therapeutic activity in patients. We aim to systematically
Externí odkaz:
https://doaj.org/article/79a625e34918435f841f28673c9cdf62
Autor:
Kathrin Olschok, Bianca Altenburg, Marcelo A. S. de Toledo, Angela Maurer, Anne Abels, Fabian Beier, Deniz Gezer, Susanne Isfort, Katrin Paeschke, Tim H. Brümmendorf, Martin Zenke, Nicolas Chatain, Steffen Koschmieder
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Imetelstat shows activity in patients with myeloproliferative neoplasms, including primary myelofibrosis (PMF) and essential thrombocythemia. Here, we describe a case of prolonged disease stabilization by imetelstat treatment of a high-risk PMF patie
Externí odkaz:
https://doaj.org/article/22f86771bc0443b6890a712facd8c199
Autor:
Kathrin Olschok, Bianca Altenburg, Marcelo A.S. de Toledo, Angela Maurer, Anne Abels, Fabian Beier, Deniz Gezer, Susanne Isfort, Tim H Brümmendorf, Martin Zenke, Nicolas Chatain, Steffen Koschmieder
Publikováno v:
HemaSphere, Vol 7, p e661233c (2023)
Externí odkaz:
https://doaj.org/article/1d8c94f874454194b3139eb4534987b7
Autor:
Taiki Satoh, Marcelo A. S. Toledo, Janik Boehnke, Kathrin Olschok, Niclas Flosdorf, Katrin Götz, Caroline Küstermann, Stephanie Sontag, Kristin Seré, Steffen Koschmieder, Tim H. Brümmendorf, Nicolas Chatain, Yoh-ichi Tagawa, Martin Zenke
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Dendritic cells (DC) are professional antigen-presenting cells that develop from hematopoietic stem cells. Different DC subsets exist based on ontogeny, location and function, including the recently identified proinflammatory DC3 subset. DC3 have the
Externí odkaz:
https://doaj.org/article/066bc1a8ca6f4f6981093117e628c953
Publikováno v:
BMC Nephrology, Vol 19, Iss 1, Pp 1-4 (2018)
Abstract Background Cystinuria is caused by the defective renal reabsorption of cystine and dibasic amino acids, and results in cystine stone formation. So far, mutations in two genes have been identified as causative. The SLC3A1/rBAT gene encodes th
Externí odkaz:
https://doaj.org/article/479113704cfd442eb160fa2595d0ab9d
Autor:
Shannon E. Elf, Scott A. Oakes, Rebekka K. Schneider, Sandeep Gurbuxani, Steffen Koschmieder, Silvia Catricala, Ilaria Carola Casetti, Daniela Pietra, Elisa Rumi, Jonathan Dowgielewicz, Luke Maxwell, Diane Silva, Benjamin Nicholson, Kathrin Olschok, Milena Kalmer, Julian Baumeister, Julian Lutze, Quinn Smith, Chenyu Liu, Althea Bock-Hughes, Maria Evers, Deborah Rodriguez, Nicole S. Arellano, Harrison S. Greenbaum, Michele Ciboddo, Katarzyna Kurylowicz, Yassmin A. Elbanna, Juan Ibarra
Approximately 20% of patients with myeloproliferative neoplasms (MPN) harbor mutations in the gene calreticulin (CALR), with 80% of those mutations classified as either type I or type II. While type II CALR-mutant proteins retain many of the Ca2+ bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016efe4195fef443d3f9880b5f0730f8
https://doi.org/10.1158/2643-3230.c.6550824
https://doi.org/10.1158/2643-3230.c.6550824
Autor:
Shannon E. Elf, Scott A. Oakes, Rebekka K. Schneider, Sandeep Gurbuxani, Steffen Koschmieder, Silvia Catricala, Ilaria Carola Casetti, Daniela Pietra, Elisa Rumi, Jonathan Dowgielewicz, Luke Maxwell, Diane Silva, Benjamin Nicholson, Kathrin Olschok, Milena Kalmer, Julian Baumeister, Julian Lutze, Quinn Smith, Chenyu Liu, Althea Bock-Hughes, Maria Evers, Deborah Rodriguez, Nicole S. Arellano, Harrison S. Greenbaum, Michele Ciboddo, Katarzyna Kurylowicz, Yassmin A. Elbanna, Juan Ibarra
Supplementary Data from Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d504c47564df319c5c1e8f5b6b7e98a
https://doi.org/10.1158/2643-3230.22545003
https://doi.org/10.1158/2643-3230.22545003
Autor:
Jessica E. Pritchard, Juliette E. Pearce, Inge A.M. Snoeren, Stijn N.R. Fuchs, Katrin Götz, Fabian Peisker, Silke Wagner, Adam Benabid, Niklas Lutterbach, Anna K. Galyga, James S. Nagai, Vanessa Krämer, Monica T. Hannani, Eric Bindels, Kathrin Olschok, Nicolas Chatain, Neha Bhagwat, Andrew Dunbar, Marie-Luise Berres, Steffen Koschmieder, Ross L. Levine, Ivan Costa, Hélène F.E. Gleitz, Rafael Kramann, Rebekka Schneider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::815ad8da44dab9254594abe7101295c7
https://doi.org/10.2139/ssrn.4381686
https://doi.org/10.2139/ssrn.4381686
Autor:
Jessica E. Pritchard, Juliette Pearce, Inge Snoeren, Stijn Fuchs, Katrin Götz, Silke Wagner, Kathrin Olschok, Nicolas Chatain, Steffen Koschmieder, Marie-Luise Berres, Ivan Costa, Helene Gleitz, Rafael Kramann, Rebekka K. Schneider
Publikováno v:
Blood. 140:6728-6729
Autor:
Juan Ibarra, Yassmin A. Elbanna, Katarzyna Kurylowicz, Michele Ciboddo, Harrison S. Greenbaum, Nicole S. Arellano, Deborah Rodriguez, Maria Evers, Althea Bock-Hughes, Chenyu Liu, Quinn Smith, Julian Lutze, Julian Baumeister, Milena Kalmer, Kathrin Olschok, Benjamin Nicholson, Diane Silva, Luke Maxwell, Jonathan Dowgielewicz, Elisa Rumi, Daniela Pietra, Ilaria Carola Casetti, Silvia Catricala, Steffen Koschmieder, Sandeep Gurbuxani, Rebekka K. Schneider, Scott A. Oakes, Shannon E. Elf
Publikováno v:
Blood Cancer Discov
Approximately 20% of patients with myeloproliferative neoplasms (MPN) harbor mutations in the gene calreticulin (CALR), with 80% of those mutations classified as either type I or type II. While type II CALR-mutant proteins retain many of the Ca2+ bin