Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Kathrin Mutze"'
Autor:
Mareike Lehmann, Lara Buhl, Hani N. Alsafadi, Stephan Klee, Sarah Hermann, Kathrin Mutze, Chiharu Ota, Michael Lindner, Jürgen Behr, Anne Hilgendorff, Darcy E. Wagner, Melanie Königshoff
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to fibroblast activation,
Externí odkaz:
https://doaj.org/article/490e2e229a1041e6880a6aabd3226b70
Autor:
Andrea Coluccio, Stefanie Tippmer, Petra Prinz, Maja Buerdek, Kathrin Mutze, Barbara Loesch, Kathrin Davari, Giulia Longinotti, Dolores J. Schendel
Publikováno v:
Cancer Research. 83:4057-4057
T cell receptor (TCR)-based immunotherapies have shown great potential for the safe and efficacious treatment of patients suffering from various solid malignancies. However, novel strategies are needed to overcome the immunosuppressive tumor microenv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfff739fbccc53bb0aad582e1f20ae0c
https://doi.org/10.1158/1538-7445.am2023-4057
https://doi.org/10.1158/1538-7445.am2023-4057
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 8, Pp 877-890 (2015)
The alveolar epithelium represents a major site of tissue destruction during lung injury. It consists of alveolar epithelial type I (ATI) and type II (ATII) cells. ATII cells are capable of self-renewal and exert progenitor function for ATI cells upo
Externí odkaz:
https://doaj.org/article/3b61ca0e185b40cbb3bf83954da29072
Autor:
Nadja Sailer, Ina Fetzer, Melanie Salvermoser, Monika Braun, Doris Brechtefeld, Christian Krendl, Christiane Geiger, Kathrin Mutze, Elfriede Noessner, Dolores Schendel, Maja Bürdek, Susanne Wilde, Daniel Sommermeyer
Publikováno v:
Cancers; Volume 14; Issue 8; Pages: 1998
Cancers 14:1998 (2022)
Cancers 14:1998 (2022)
The hostile tumor microenvironment (TME) is a major challenge for the treatment of solid tumors with T-cell receptor (TCR)-modified T-cells (TCR-Ts), as it negatively influences T-cell efficacy, fitness, and persistence. These negative influences are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734ea08f4286c3788b7e3656b3a661de
Autor:
Stefan Dehmel, Katharina J. Weiss, Natalia El-Merhie, Jens Callegari, Birte Konrad, Kathrin Mutze, Oliver Eickelberg, Melanie Königshoff, Susanne Krauss-Etschmann
Publikováno v:
Genes; Volume 13; Issue 8; Pages: 1420
Genes 13:1420 (2022)
Genes 13:1420 (2022)
Alveolar type II (ATII) cells are essential for the maintenance of the alveolar homeostasis. However, knowledge of the expression of the miRNAs and miRNA-regulated networks which control homeostasis and coordinate diverse functions of murine ATII cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd990d972d38ef9f4c2b3e4644dbae7a
https://doi.org/10.3390/genes13081420
https://doi.org/10.3390/genes13081420
Autor:
Kathrin Mutze, Lara Buhl, Darcy E. Wagner, Chiharu Ota, Jürgen Behr, Mareike Lehmann, Stephan Klee, Sarah Hermann, Hani N. Alsafadi, Michael Lindner, Melanie Königshoff, Anne Hilgendorff
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-12 (2018)
Respiratory Research
Respir. Res. 19:175 (2018)
Respiratory Research
Respir. Res. 19:175 (2018)
Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive injury and reprogramming of the lung epithelium are thought to be critical drivers of disease progression, contributing to fibroblast activation, extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dee32961a64f6c15ab759210266b35
http://link.springer.com/article/10.1186/s12931-018-0876-y
http://link.springer.com/article/10.1186/s12931-018-0876-y
Autor:
Olivier Burgy, Carlo Mümmler, Kathrin Mutze, Melanie Königshoff, Andreas Günther, Sarah Hermann
Publikováno v:
FASEB J. 32, 703-716 (2017)
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with limited therapeutic options and unknown etiology. IPF is characterized by epithelial cell injury, impaired cellular crosstalk between epithelial cells and fibroblasts, and the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d851242404f76de8cbb0b82a9cf63430
https://doi.org/10.1096/fj.201700482r
https://doi.org/10.1096/fj.201700482r
Autor:
Mareike Lehmann, Hoeke A. Baarsma, Ken R. Bracke, Rita Costa, Wioletta Skronska-Wasek, Darcy E. Wagner, Melanie Königshoff, Hani N. Alsafadi, Mariano Stornaiuolo, Guy Brusselle, Ettore Novellino, Ali Önder Yildirim, Kathrin Mutze
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 196:172-185
Chronic obstructive pulmonary disease (COPD), in particular emphysema, is characterized by loss of parenchymal alveolar tissue and impaired tissue repair. Wingless and INT-1 (WNT)/β-catenin signaling is reduced in COPD; however, the mechanisms there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873f9352f9b4a9e3c324a696c3abba37
https://doi.org/10.1164/rccm.201605-0904oc
https://doi.org/10.1164/rccm.201605-0904oc
Autor:
Andreas Günther, Ron Smits, Florian Ciolek, Melanie Königshoff, Katharina Heinzelmann, Wioletta Skronska-Wasek, Aö Yildirim, Guy Brusselle, Maylis Dagouassat, Oliver Eickelberg, Jorge Boczkowski, Ken R. Bracke, Darcy E. Wagner, Gerrit John-Schuster, Hoeke A. Baarsma, Kathrin Mutze
Publikováno v:
J. Exp. Med. 214, 143-163 (2017)
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2017, 214 (1), pp.143-163. ⟨10.1084/jem.20160675⟩
Journal of Experimental Medicine, 214(1), 143-163. Rockefeller University Press
JOURNAL OF EXPERIMENTAL MEDICINE
The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2017, 214 (1), pp.143-163. ⟨10.1084/jem.20160675⟩
Journal of Experimental Medicine, 214(1), 143-163. Rockefeller University Press
JOURNAL OF EXPERIMENTAL MEDICINE
The Journal of Experimental Medicine
Baarsma et al. report increased expression and posttranslational modification of the noncanonical ligand WNT-5A in COPD. Fibroblast-derived WNT-5A inhibits canonical WNT–β-catenin–driven alveolar epithelial cell–mediated wound healing and tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d72c8afa957908a700cfaa4741e73ce
https://doi.org/10.1084/jem.20160675
https://doi.org/10.1084/jem.20160675
Publikováno v:
Mechanisms of lung injury and repair.
Introduction: Idiopathic pulmonary fibrosis (IPF) is a devastating, age-related lung disease with limited therapeutic options. Several hallmarks of aging such as cellular senescence are present in disease along with the aberrant activation of develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29a05e947beaee19b1c271e1ee9af866
https://doi.org/10.1183/13993003.congress-2019.pa4122
https://doi.org/10.1183/13993003.congress-2019.pa4122