The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation.

Autor: Christopher Tiedje, Natalia Ronkina, Mohammad Tehrani, Sonam Dhamija, Kathrin Laass, Helmut Holtmann, Alexey Kotlyarov, Matthias Gaestel

Publikováno v: PLoS Genetics, Vol 8, Iss 9, p e1002977 (2012)

TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF.

Externí odkaz: https://doaj.org/article/c47124af1ad44a4bacf332f94a2a70bf

Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK

Autor: Lisa Bohlmann, Christopher Tiedje, Kathrin Laaß, Claus Johansen, Natalia Ronkina, Juri Lafera, Lars Iversen, Alexey Kotlyarov, Benjamin E. Turk, Matthias Gaestel, Manoj B. Menon

Publikováno v: Ronkina, N, Johansen, C, Bohlmann, L, Lafera, J, Menon, M B, Tiedje, C, Laaß, K, Turk, B E, Iversen, L, Kotlyarov, A & Gaestel, M 2015, ' Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK ', PLOS ONE, vol. 10, no. 8, pp. e0136138 . https://doi.org/10.1371/journal.pone.0136138
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0136138 (2015)

MK5 (MAPK-activated protein kinase 5) or PRAK (p38-regulated and -activated kinase) are alternative names for a serine/threonine protein kinase downstream to ERK3/4 and p38 MAPK. A previous gene targeting approach for MK5/PRAK (termed here MK5/PRAK-�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235ab6850ae6872d89c9796f2583ccfc
https://pure.au.dk/portal/da/publications/comparative-analysis-of-two-genetargeting-approaches-challenges-the-tumorsuppressive-role-of-the-protein-kinase-mk5prak(3b615bc8-afdb-4474-97e3-8f94041cc0a1).html

Heat Shock Protein 27 Is a Substrate of cGMP-dependent Protein Kinase in Intact Human Platelets

Autor: Kathrin Laaß, Elke Butt, Matthias Gaestel, Helmut E. Meyer, Dorian Immler, Alexey Kotlyarov

Publikováno v: Journal of Biological Chemistry. 276:7108-7113

Phosphorylation of heat shock protein 27 (Hsp27) in human platelets by mitogen-activated protein kinase-activated protein kinase (MAPKAP) 2 is associated with signaling events involved in platelet aggregation and regulation of microfilament organizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d02278e0edb3d1b551864ec557c1e493
https://doi.org/10.1074/jbc.m009234200

Elimination of Protein Kinase MK5/PRAK Activity by Targeted Homologous Recombination

Autor: Matthias Gaestel, Achim D. Gruber, Hans-Dieter Volk, Helmut E. Meyer, Kathrin Laaß, Elke Butt, Katrin Marcus, Yu Shi, Alexey Kotlyarov, Anke Friedrich

MK5 (mitogen-activated protein kinase [MAPK]-activated protein kinase 5), also designated PRAK (p38-regulated and -activated kinase), was deleted from mice by homologous recombination. Although no MK5 full-length protein and kinase activity was detec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124559593b212ef36a56edfd251cf37f
https://europepmc.org/articles/PMC207624/