Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production.

Autor: Benjamin J Hulme, Kathrin K Geyer, Josephine E Forde-Thomas, Gilda Padalino, Dylan W Phillips, Wannaporn Ittiprasert, Shannon E Karinshak, Victoria H Mann, Iain W Chalmers, Paul J Brindley, Cornelis H Hokke, Karl F Hoffmann

Publikováno v: PLoS Pathogens, Vol 18, Iss 1, p e1009828 (2022)

α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins and lipids. Mutations in the human genes encoding either en

Externí odkaz: https://doaj.org/article/05828ee02d5c4a1e99b9770422f25c16

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni.

Autor: Kathrin K Geyer, Sabrina E Munshi, Helen L Whiteland, Narcis Fernandez-Fuentes, Dylan W Phillips, Karl F Hoffmann

Publikováno v: PLoS Pathogens, Vol 14, Iss 6, p e1007107 (2018)

While schistosomiasis remains a significant health problem in low to middle income countries, it also represents a recently recognised threat to more economically-developed regions. Until a vaccine is developed, this neglected infectious disease is p

Externí odkaz: https://doaj.org/article/4fdda7941f26401a91fa677efc81d543

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni.

Autor: Kathrin K Geyer, Umar H Niazi, David Duval, Céline Cosseau, Chad Tomlinson, Iain W Chalmers, Martin T Swain, David J Cutress, Utibe Bickham-Wright, Sabrina E Munshi, Christoph Grunau, Timothy P Yoshino, Karl F Hoffmann

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005246 (2017)

The debilitating human disease schistosomiasis is caused by infection with schistosome parasites that maintain a complex lifecycle alternating between definitive (human) and intermediate (snail) hosts. While much is known about how the definitive hos

Externí odkaz: https://doaj.org/article/797dd218475a4031b6b8c2e495d32c04

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Autor: Shannon E. Karinshak, Dylan Phillips, Gilda Padalino, Cornelis H. Hokke, Victoria H. Mann, Wannaporn Ittiprasert, Karl F. Hoffmann, Paul J. Brindley, Josephine Forde-Thomas, Iain W. Chalmers, Kathrin K. Geyer, Benjamin J. Hulme

α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins and lipids. Mutations in the human genes encoding either en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::414322cfb2b4b45b9744ad77af6d2216
https://doi.org/10.1101/2021.07.26.453800

Characterisation of serum IgG(T) responses to potential diagnostic antigens for equine cyathostominosis

Autor: Mairi C. Mitchell, Stewart T. G. Burgess, Jacqueline B. Matthews, Kathrin K. Geyer, Thomas Tzelos, Hamish E G McWilliam, Vitaliy O. Kharchenko

Publikováno v: Tzelos, T, Geyer, K K, Mitchell, M C, MCWILLIAM, HAMISH E G, Kharchenko, V O, BURGESS, STEWART T G & Matthews, J 2020, ' Characterisation of serum IgG(T) responses to potential diagnostic antigens for equine cyathostominosis ', Int J Parasitol . https://doi.org/10.1016/j.ijpara.2020.01.004

Cyathostomins are ubiquitous parasitic nematodes of horses. These worms spend substantial periods as intestinal wall stage encysted larvae, which can comprise up to 90% of the total burden. Several million larvae have been reported in individuals. Em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b457b2022a27ea1174e1434f5f4b5911
https://www.pure.ed.ac.uk/ws/files/131010542/tzelos_et_al_2020_IJP_Characterisation_of_serum_IgG_T_responses_to_potential_diagnostic_antigens_for_equine_cyathostominosis.pdf