Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kathrin Hueging"'
Autor:
Alexander W. Tarr, Tanvi Khera, Kathrin Hueging, Julie Sheldon, Eike Steinmann, Thomas Pietschmann, Richard J. P. Brown
Publikováno v:
Viruses, Vol 7, Iss 7, Pp 3995-4046 (2015)
In the 26 years since the discovery of Hepatitis C virus (HCV) a major global research effort has illuminated many aspects of the viral life cycle, facilitating the development of targeted antivirals. Recently, effective direct-acting antiviral (DAA)
Externí odkaz:
https://doaj.org/article/0610fe48b9d2403d8e72abe57abceda4
Autor:
Markus von Schaewen, Marcus Dorner, Kathrin Hueging, Lander Foquet, Sherif Gerges, Gabriela Hrebikova, Brigitte Heller, Julia Bitzegeio, Juliane Doerrbecker, Joshua A. Horwitz, Gisa Gerold, Sebastian Suerbaum, Charles M. Rice, Philip Meuleman, Thomas Pietschmann, Alexander Ploss
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT Hepatitis C virus (HCV) species tropism is incompletely understood. We have previously shown that at the level of entry, human CD81 and occludin (OCLN) comprise the minimal set of human factors needed for viral uptake into murine cells. As a
Externí odkaz:
https://doaj.org/article/1244794fd1604668930279a7182f7600
Autor:
Kathrin Hueging, Romy Weller, Mandy Doepke, Gabrielle Vieyres, Daniel Todt, Benno Wölk, Florian W R Vondran, Robert Geffers, Chris Lauber, Lars Kaderali, François Penin, Thomas Pietschmann
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134529 (2015)
Apolipoprotein E (ApoE), an exchangeable apolipoprotein, is necessary for production of infectious Hepatitis C virus (HCV) particles. However, ApoE is not the only liver-expressed apolipoprotein and the role of other apolipoproteins for production of
Externí odkaz:
https://doaj.org/article/c93de4576d374b46a028a2c47e51e73e
Autor:
Nicolas Menzel, Wolfgang Fischl, Kathrin Hueging, Dorothea Bankwitz, Anne Frentzen, Sibylle Haid, Juliane Gentzsch, Lars Kaderali, Ralf Bartenschlager, Thomas Pietschmann
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002829 (2012)
Hepatitis C virus (HCV) has infected around 160 million individuals. Current therapies have limited efficacy and are fraught with side effects. To identify cellular HCV dependency factors, possible therapeutic targets, we manipulated signaling cascad
Externí odkaz:
https://doaj.org/article/60b449c1cbb44d7fa6971dd322b50980
Autor:
Julia Bitzegeio, Dorothea Bankwitz, Kathrin Hueging, Sibylle Haid, Christiane Brohm, Mirjam B Zeisel, Eva Herrmann, Marcus Iken, Michael Ott, Thomas F Baumert, Thomas Pietschmann
Publikováno v:
PLoS Pathogens, Vol 6, p e1000978 (2010)
Hepatitis C virus (HCV) naturally infects only humans and chimpanzees. The determinants responsible for this narrow species tropism are not well defined. Virus cell entry involves human scavenger receptor class B type I (SR-BI), CD81, claudin-1 and o
Externí odkaz:
https://doaj.org/article/8993a7a785aa4054a305c13b2cffd220
Autor:
Michael P. Manns, Janina Bruening, Ji-Young Lee, Patrick Behrendt, Thomas Pietschmann, Dorothea Bankwitz, Kathrin Hueging, Mandy Doepke, Florian W. R. Vondran, Romy Weller, Ralf Bartenschlager
Publikováno v:
Journal of Hepatology. 67:480-489
Background & Aims Hepatitis C virus (HCV) evades humoral immunity and establishes chronic infections. Virus particles circulate in complex with lipoproteins facilitating antibody escape. Apolipoprotein E (ApoE) is essential for intracellular HCV asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2988f585b91da1bb319d8fa9a75d8e7
https://doi.org/10.1016/j.jhep.2017.04.010
https://doi.org/10.1016/j.jhep.2017.04.010
Autor:
Kathrin Hueging, Thomas Pietschmann, Tanvi Khera, Richard J. C. Brown, Julie Sheldon, Alexander W. Tarr, Eike Steinmann
Publikováno v:
Viruses, Vol 7, Iss 7, Pp 3995-4046 (2015)
Viruses
Viruses
In the 26 years since the discovery of Hepatitis C virus (HCV) a major global research effort has illuminated many aspects of the viral life cycle, facilitating the development of targeted antivirals. Recently, effective direct-acting antiviral (DAA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bef221b9e20a6002d36259dd0f5edf1
https://doi.org/10.3390/v7072809
https://doi.org/10.3390/v7072809
Autor:
Kathrin Hueging, Florian W. R. Vondran, Thomas Pietschmann, Romy Weller, Sebastian Joecks, Daniel Todt, Richard J. C. Brown
Publikováno v:
Journal of virology
Journal of Virology
Journal of Virology
Hepatitis C virus (HCV) is extraordinarily diverse and uses entry factors in a strain-specific manner. Virus particles associate with lipoproteins, and apolipoprotein E (ApoE) is critical for HCV assembly and infectivity. However, whether ApoE depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f89af578c07414b5402a95f5cedc04
https://doi.org/10.1128/jvi.00422-17
https://doi.org/10.1128/jvi.00422-17
Autor:
Kathrin Hueging, Mandy Doepke, Julia Bitzegeio, Dorothea Bankwitz, Maria Teresa Catanese, Alfredo Nicosia, Lars Kaderali, Thomas F. Baumert, Mirjam B. Zeisel, Gabrielle Vieyres, Sibylle Haid, Patrick Chhatwal, Thomas Pietschmann
Publikováno v:
Journal of Virology
Journal of Virology, American Society for Microbiology, 2014, 88 (21), pp.12644-12655. ⟨10.1128/jvi.01145-14⟩
Journal of Virology, American Society for Microbiology, 2014, 88 (21), pp.12644-12655. ⟨10.1128/jvi.01145-14⟩
Hepatitis C virus (HCV) particles associate with lipoproteins and infect cells by using at least four cell entry factors. These factors include scavenger receptor class B type I (SR-BI), CD81, claudin 1 (CLDN1), and occludin (OCLN). Little is known a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0877e563cf821a6871de6da57c888a9c
https://doi.org/10.1128/jvi.01145-14
https://doi.org/10.1128/jvi.01145-14
Autor:
Lars Kaderali, Engin Gürlevik, Corinne Ginkel, Anggakusuma, Ulrich Kalinke, Markus H. Heim, F. Kuehnel, Anne Frentzen, Richard J. C. Brown, Michael T. Dill, Andrea Kröger, Kathrin Hueging, Sarah Knocke, Thomas Pietschmann
Publikováno v:
Hepatology. 59:78-88
Only humans and chimpanzees are susceptible to chronic infection by hepatitis C virus (HCV). The restricted species tropism of HCV is determined by distinct host factor requirements at different steps of the viral life cycle. In addition, effective i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1153656d37f97318bd3742f82f955e4c
https://doi.org/10.1002/hep.26626
https://doi.org/10.1002/hep.26626