Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kathrin Hnida"'
Autor:
Kathrin Hnida, Gerry Melino, Chakravarthi Kanduri, Shuo-Wang Qiao, Alisa E. Dewan, Marie K. Johannesen, Jana Blazevski, Lars Fugger, Jorunn Stamnaes, Geir Kjetil Sandve, Christian B. Lindstad, Ludvig M. Sollid, Fleur du Pré
Publikováno v:
Cell Death & Disease
du Pré, M F, Blazevski, J, Dewan, A E, Stamnaes, J, Kanduri, C, Sandve, G K, Johannesen, M K, Lindstad, C B, Hnida, K, Fugger, L, Melino, G, Qiao, S-W & Sollid, L M 2020, ' B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2 ', The Journal of Experimental Medicine, vol. 217, no. 2, e20190860 . https://doi.org/10.1084/jem.20190860
du Pré, M F, Blazevski, J, Dewan, A E, Stamnaes, J, Kanduri, C, Sandve, G K, Johannesen, M K, Lindstad, C B, Hnida, K, Fugger, L, Melino, G, Qiao, S-W & Sollid, L M 2020, ' B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2 ', The Journal of Experimental Medicine, vol. 217, no. 2, e20190860 . https://doi.org/10.1084/jem.20190860
Autoantibodies to transglutaminase 2 (TG2) are hallmarks of celiac disease. To address B cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac patient–derived anti-TG2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d878d3494274676f8d7560c90b319a1d
https://ora.ox.ac.uk/objects/uuid:1985a996-ef0c-4d6c-902b-e0f131fcc719
https://ora.ox.ac.uk/objects/uuid:1985a996-ef0c-4d6c-902b-e0f131fcc719
Autor:
Ludvig M. Sollid, Bishnudeo Roy, Rasmus Iversen, Ralf Stefan Neumann, Kathrin Hnida, Ilma Rita Korponay-Szabó, Knut E.A. Lundin, Lene Støkken Høydahl, Jorunn Stamnaes
B cells play important roles in autoimmune diseases through autoantibody production, cytokine secretion, or antigen presentation to T cells. In most cases, the contribution of B cells as antigen-presenting cells is not well understood. We have studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231e823e4babe3165980c6a9e291f1fc
http://hdl.handle.net/10852/70924
http://hdl.handle.net/10852/70924
Autor:
Ludvig M. Sollid, Kathrin Hnida, Rasmus Iversen, Xi Chen, Dmitri I. Svergun, Anne Tuukkanen, Melissa A. Graewert, Jan Terje Andersen
Publikováno v:
The journal of biological chemistry 290(35), 21365-21375 (2015). doi:10.1074/jbc.M115.669895
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Background: Knowledge of how celiac disease autoantibodies recognize transglutaminase 2 (TG2) is limited. Results: The interaction between TG2 and a celiac disease epitope 1 anti-TG2 antibody was studied by small angle x-ray scattering and mutational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c51dcb070b368ea75bdf2ed35acef58
https://doi.org/10.1074/jbc.m115.669895
https://doi.org/10.1074/jbc.m115.669895
Autor:
Jorunn Stamnaes, Simon Mysling, Rasmus Iversen, Kathrin Hnida, Ludvig M. Sollid, M. Fleur du Pré, Thomas J. D. Jørgensen
Publikováno v:
Hnida, K, Stamnaes, J, du Pré, M F, Mysling, S, Jørgensen, T J D, Sollid, L M & Iversen, R 2016, ' Epitope-dependent functional effects of celiac disease autoantibodies on transglutaminase 2 ', Journal of Biological Chemistry, vol. 291, no. 49, pp. 25542-25552 . https://doi.org/10.1074/jbc.M116.738161
Transglutaminase 2 (TG2) is a Ca(2+)-dependent cross-linking enzyme involved in the pathogenesis of CD. We have previously characterized a panel of anti-TG2 mAbs generated from gut plasma cells of celiac patients and identified four epitopes (epitope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f842a25c6d4839631a0a4346ed69d18
https://pubmed.ncbi.nlm.nih.gov/27784785
https://pubmed.ncbi.nlm.nih.gov/27784785
Autor:
Knut E.A. Lundin, Elin Bergseng, Jorunn Stamnaes, Xi Chen, Omri Snir, Kathrin Hnida, Inês Cardoso, M. Fleur du Pré, Rasmus Iversen, Shuo-Wang Qiao, Siri Dørum, Asbjørn Christophersen, Ludvig M. Sollid, Øyvind Steinsbø
Publikováno v:
Digestive diseases (Basel, Switzerland). 33(2)
Background: Celiac disease is a multifactorial and polygenic disease with autoimmune features. The disease is caused by an inappropriate immune response to gluten. Elimination of gluten from the diet leads to disease remission, which is the basis for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c47d507dcf76074cfa3045ad16a4989
https://pubmed.ncbi.nlm.nih.gov/25925911
https://pubmed.ncbi.nlm.nih.gov/25925911
Publikováno v:
Iversen, R, Mysling, S, Hnida, K, Jørgensen, T J D & Sollid, L M 2014, ' Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange ', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 48, pp. 17146-51 . https://doi.org/10.1073/pnas.1407457111
The multifunctional enzyme transglutaminase 2 (TG2) is the target of autoantibodies in the gluten-sensitive enteropathy celiac disease. In addition, the enzyme is responsible for deamidation of gluten peptides, which are subsequently targeted by T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d5a0c4b04c84afe928f8e91bfbfbee
https://europepmc.org/articles/PMC4260576/
https://europepmc.org/articles/PMC4260576/