Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Kathrin Held"'
Autor:
Mohamed I.M. Ahmed, Sebastian Einhauser, Clemens Peiter, Antonia Senninger, Olga Baranov, Tabea M. Eser, Manuel Huth, Laura Olbrich, Noemi Castelletti, Raquel Rubio-Acero, George Carnell, Jonathan Heeney, Inge Kroidl, Kathrin Held, Andreas Wieser, Christian Janke, Michael Hoelscher, Jan Hasenauer, Ralf Wagner, Christof Geldmacher
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110138- (2024)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron breakthrough infection (BTI) induced better protection than triple vaccination. To address the underlying immunological mechanisms, we studied antibody and T cell response
Externí odkaz:
https://doaj.org/article/b77f4a3eaeb9481cb6597a1bee28504a
Autor:
Tabea M. Eser, Olga Baranov, Manuel Huth, Mohammed I. M. Ahmed, Flora Deák, Kathrin Held, Luming Lin, Kami Pekayvaz, Alexander Leunig, Leo Nicolai, Georgios Pollakis, Marcus Buggert, David A. Price, Raquel Rubio-Acero, Jakob Reich, Philine Falk, Alissa Markgraf, Kerstin Puchinger, Noemi Castelletti, Laura Olbrich, Kanika Vanshylla, Florian Klein, Andreas Wieser, Jan Hasenauer, Inge Kroidl, Michael Hoelscher, Christof Geldmacher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear precisely which components of the early immune response protect against the development of severe COVID-19. Here, we perform a comprehensive immunogenetic
Externí odkaz:
https://doaj.org/article/4dc5d871135c41fe9339d69cb0120fce
Autor:
Augusta Horvath, Lisa Rogers, Georgios Pollakis, Olga Baranov, Nora Pieroth, Sarah Joseph, Mkunde Chachage, Asli Heitzer, Lucas Maganga, Frank Msafiri, Agricola Joachim, Edna Viegas, Leigh-Anne Eller, Hannah Kibuuka, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jittima Dhitavat, Nakorn Premsri, Sarah Fidler, Robin J. Shattock, Merlin Lee Robb, Jonathan Weber, Sheena McCormack, Patricia Jane Munseri, Eligius Lyamuya, Charlotta Nilsson, Arne Kroidl, Michael Hoelscher, Ralf Wagner, Christof Geldmacher, Kathrin Held
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Immunogens and vaccination regimens can influence patterns of immune-epitope recognition, steering them towards or away from epitopes of potential viral vulnerability. HIV-1 envelope (Env)-specific antibodies targeting variable region 2 (V2) or 3 (V3
Externí odkaz:
https://doaj.org/article/df2a4d62eb904d36874c84f4d7ae26bd
Autor:
Nádia Sitoe, Imelda Chelene, Sofia Ligeiro, Celso Castiano, Mohamed I. M. Ahmed, Kathrin Held, Pedroso Nhassengo, Celso Khosa, Raquel Matavele-Chissumba, Michael Hoelscher, Andrea Rachow, Christof Geldmacher, on behalf of the TB Sequel Consortium
Publikováno v:
Pathogens, Vol 12, Iss 6, p 794 (2023)
The mycobacteriological analysis of sputum samples is the gold standard for tuberculosis diagnosis and treatment monitoring. However, sputum production can be challenging after the initiation of TB treatment. As a possible alternative, we therefore i
Externí odkaz:
https://doaj.org/article/c4aad76635cf4962a0d7f4798f9bee51
Autor:
Ursula Panzner, Katharina Kranzer, Tsitsi Bandason, Kuda Mutasa, Sandra Rukobo, Charles Sandy, Bariki Mtafya, Andrea Rachow, Norbert Heinrich, Michael Hoelscher, Judith Bruchfeld, Olena Ivanova, Nyanda Elias Ntinginya, Doreen Pamba, Laura Olbrich, Issa Sabi, Simeon Mwanyonga, Elmar Saathoff, Willyhelmina Olomi, Junior Mutsvangwa, Hazel M Dockrell, Edson Tawanda Marambire, Denise Banze, Alfred Mfinanga, Theodora D Mbunda, Khosa Celso, Gunilla Kallenius, Claire J Calderwood, Christof Geldmacher, Kathrin Held, Tejaswi Appalarowthu, Friedrich Rieß, Anna Shepherd, Christopher Sundling, Mishelle Mugava, Martha Chipinduro, Lwitiho Sudi, Antelmo Haule, Emmanuel Sichone, Paschal Qwaray, Harrieth Mwambola, Lilian Minja, Peter Edwin, Dogo Ngalison, Stella Luswema, Celina Nhamuave, António Machiana, Carla Madeira, Emelva Manhiça, Nádia Sitoe, Jorge Ribeiro
Publikováno v:
BMJ Open, Vol 12, Iss 7 (2022)
Introduction The WHO End-TB Strategy calls for the development of novel diagnostics to detect tuberculosis (TB) earlier and more accurately. Better diagnostics, together with tools to predict disease progression, are critical for achieving WHO End-TB
Externí odkaz:
https://doaj.org/article/8e5324444e6a4d10a487d5a6da243a6b
Autor:
Wilbert Mbuya, Kathrin Held, Ruby D. Mcharo, Antelmo Haule, Jacklina Mhizde, Jonathan Mnkai, Anifrid Mahenge, Maria Mwakatima, Margareth Sembo, Wolfram Mwalongo, Peter Agrea, Michael Hoelscher, Leonard Maboko, Elmar Saathoff, Otto Geisenberger, France Rwegoshora, Liset Torres, Richard A. Koup, Arne Kroidl, Mkunde Chachage, Christof Geldmacher
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundCervical cancer - caused by persistent High Risk Human Papilloma Virus (HR HPV) infections - is the second most common cancer affecting women globally. HIV infection increases the risk for HPV persistence, associated disease progression and
Externí odkaz:
https://doaj.org/article/2f9c7e15a0254526b38b90ee19cae850
Autor:
Nádia Sitoe, Mohamed I. M. Ahmed, Maria Enosse, Abhishek Bakuli, Raquel Matavele Chissumba, Kathrin Held, Michael Hoelscher, Pedroso Nhassengo, Celso Khosa, Andrea Rachow, Christof Geldmacher, on behalf of TB Sequel Consortium
Publikováno v:
Pathogens, Vol 11, Iss 9, p 1034 (2022)
HIV infection causes systemic immune activation, impacts TB disease progression and hence may influence the diagnostic usability of Mycobacterium tuberculosis-specific T cell profiling. We investigated changes of activation and maturation markers on
Externí odkaz:
https://doaj.org/article/df7a1046d54b4b0d86a6ff6bcdbd545a
Autor:
Matea Konjevic Sabolek, Kathrin Held, Eduardo Beltrán, Anna G. Niedl, Edgar Meinl, Reinhard Hohlfeld, Hans Lassmann, Klaus Dornmair
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 7, Pp 1151-1164 (2019)
Abstract Objective CD8+ T cells are the most prevailing lymphocyte population in inflammatory lesions of patients with multiple sclerosis (MS) but it is not even known whether they are merely passive bystanders or actively communicate with other cell
Externí odkaz:
https://doaj.org/article/a533e9b65ada4237a45ef0474b841ca2
Autor:
Agricola Joachim, Mohamed I. M. Ahmed, Georgios Pollakis, Lisa Rogers, Verena S. Hoffmann, Patricia Munseri, Said Aboud, Eligius F. Lyamuya, Muhammad Bakari, Merlin L. Robb, Britta Wahren, Eric Sandstrom, Charlotta Nilsson, Gunnel Biberfeld, Christof Geldmacher, Kathrin Held
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
In the RV144 trial, to date the only HIV-1 vaccine efficacy trial demonstrating a modestly reduced risk of HIV-1 acquisition, antibody responses toward the HIV Envelope protein (Env) variable (V) 2 and V3 regions were shown to be correlated with a re
Externí odkaz:
https://doaj.org/article/a6153add16474f8d869ab4d4e5ed1cb1
Autor:
Wilbert Mbuya, Ruby Mcharo, Jacklina Mhizde, Jonathan Mnkai, Anifrid Mahenge, Maria Mwakatima, Wolfram Mwalongo, Nhamo Chiwerengo, Michael Hölscher, Tessa Lennemann, Elmar Saathoff, France Rwegoshora, Liset Torres, Arne Kroidl, Christof Geldmacher, Kathrin Held, Mkunde Chachage
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240154 (2020)
BackgroundThe burden of HPV-associated premalignant and malignant cervical lesions remains high in HIV+ women even under ART treatment. In order to identify possible underlying pathophysiologic mechanisms, we studied activation and HIV co-receptor ex
Externí odkaz:
https://doaj.org/article/88ae3e1dac354b42855eae443713ad90