Výsledky vyhledávání - "Kathrin Buchholz"

Akademický článek

Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite.

Autor: Kathrin Buchholz, Stefan Rahlfs, R Heiner Schirmer, Katja Becker, Kai Matuschewski

Publikováno v: PLoS ONE, Vol 3, Iss 6, p e2474 (2008)

Proliferation of the pathogenic Plasmodium asexual blood stages in host erythrocytes requires an exquisite capacity to protect the malaria parasite against oxidative stress. This function is achieved by a complex antioxidant defence system composed o

Externí odkaz: https://doaj.org/article/e48728d037a549cea859edf74ce3621a

Zobrazit plný text záznamu

Stable Integration and Comparison of hGrx1-roGFP2 and sfroGFP2 Redox Probes in the Malaria Parasite Plasmodium falciparum

Autor: Stefan Rahlfs, Anna Katharina Schuh, Franziska Mohring, Stine Weder, Katja Becker, Stanislaw J. Gabryszewski, Mahsa Rahbari, Kathrin Buchholz, David A. Fidock, Kim C. Heimsch

Studying redox metabolism in malaria parasites is of great interest for understanding parasite biology, parasite-host interactions, and mechanisms of drug action. Genetically encoded fluorescent redox sensors have recently been described as powerful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521f573cbfc08ac11e6b4ffc7844618a
https://europepmc.org/articles/PMC6402873/

Zobrazit plný text záznamu

Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug

Autor: Rui Moreira, Filipa P. da Cruz, Michael Hannus, Kathrin Buchholz, Miguel Prudêncio, Maria M. Mota, Maria J. Lafuente-Monasterio, Matthias Marti, Cecilie Martin, Francisco-Javier Gamo, Birte Sönnichsen, Tiago Rodrigues

Publikováno v: The Journal of Infectious Diseases
The Journal of Infectious Diseases, 205 (8)
Journal of Infectious Diseases
Journal of Infectious Diseases; Vol 205

Plasmodium parasites undergo a clinically silent and obligatory developmental phase in the host's liver cells before they are able to infect erythrocytes and cause malaria symptoms. To overcome the scarcity of compounds targeting the liver stage of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb88b98c94c9215e92cb01f304ba839
http://doc.rero.ch/record/291068/files/jis184.pdf

Zobrazit plný text záznamu

A High-Throughput Screen Targeting Malaria Transmission Stages Opens New Avenues for Drug Development

Autor: Thomas A. Burke, Roger C. Wiegand, Kim C. Williamson, Dyann F. Wirth, Kathrin Buchholz, Matthias Marti

Publikováno v: The Journal of Infectious Diseases

A major goal of the worldwide malaria eradication program is the reduction and eventual elimination of malaria transmission. All currently available antimalarial compounds were discovered on the basis of their activity against the asexually reproduci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53aeb02f728981d46a43b86a48e2ff9
https://doi.org/10.1093/infdis/jir037

Zobrazit plný text záznamu

Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products

Autor: Kathrin Buchholz, R. Luise Krauth-Siegel, Marcelo A. Comini, Dirk Wissenbach, Stephan Gromer, R. Heiner Schirmer

Publikováno v: Molecular and Biochemical Parasitology. 160:65-69

Methylene blue (MB) is known to have trypanocidal activity. We tested the interactions of MB with a number of trypanosomatid-specific molecules of the antioxidant metabolism. At pH 7, trypanothione and other (di)thiols were oxidized to disulfides by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8303c48a9e4a51fc9903c884dfb7b4b2
https://doi.org/10.1016/j.molbiopara.2008.03.006

Zobrazit plný text záznamu

An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development

Autor: Kathrin Buchholz, Kristine Werling, Matthias Marti, Ilana Goldowitz, Nicolas M. B. Brancucci

Publikováno v: Nature protocols

Conversion from asexual proliferation to sexual differentiation initiates the production of the gametocyte, which is the malaria parasite stage required for human-to-mosquito transmission. This protocol describes an assay designed to probe the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be4af56ebbf390762602e489e973ff2
https://pubmed.ncbi.nlm.nih.gov/26134953

Zobrazit plný text záznamu

Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection

Autor: Danny A. Milner, Karl B. Seydel, Terrie E. Taylor, Nicolas M. B. Brancucci, Kathrin Buchholz, Siyuan Ma, Vagheesh M. Narasimhan, Regina Joice, Natasha S. Barteneva, Curtis Huttenhower, Till S. Voss, Karell G. Pellé, Keunyoung Oh, Matthias Marti, Ken Ketman

Publikováno v: Genome Medicine
GENOME MEDICINE
Genome medicine

Background During intra-erythrocytic development, late asexually replicating Plasmodium falciparum parasites sequester from peripheral circulation. This facilitates chronic infection and is linked to severe disease and organ-specific pathology includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a500e42d170573e09c54a0f7f8ef00
https://edoc.unibas.ch/36605/

Zobrazit plný text záznamu

Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters

Autor: Elizabeth S. Egan, Manoj T. Duraisingh, Prashant Prabhat, Matthias Marti, Natasha S. Barteneva, Kathrin Buchholz, Ivan A. Vorobjev, Kenneth James Ketman

Publikováno v: Malaria Journal, Vol 11, Iss 1, p 312 (2012)
Malaria Journal

Background Malaria remains a major cause of morbidity and mortality worldwide. Flow cytometry-based assays that take advantage of fluorescent protein (FP)-expressing malaria parasites have proven to be valuable tools for quantification and sorting of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe9b414034cd7b64b01272ffac6e1a0
http://www.malariajournal.com/content/11/1/312

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání