Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Kathrin Buchholz"'
Autor:
Isabell Berneburg, Satyamaheshwar Peddibhotla, Kim C. Heimsch, Kristina Haeussler, Patrick Maloney, Palak Gosalia, Janina Preuss, Mahsa Rahbari, Oleksii Skorokhod, Elena Valente, Daniela Ulliers, Luigi Felice Simula, Kathrin Buchholz, Michael P. Hedrick, Paul Hershberger, Thomas D. Y. Chung, Michael R. Jackson, Evelin Schwarzer, Stefan Rahlfs, Lars Bode, Katja Becker, Anthony B. Pinkerton
Publikováno v:
Antimicrob Agents Chemother
In Plasmodium, the first two and rate-limiting enzymes of the pentose phosphate pathway, glucose 6-phosphate dehydrogenase (G6PD) and the 6-phosphogluconolactonase, are bifunctionally fused to a unique enzyme named GluPho, differing structurally and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b78be63f8ec7830ea15109c7201d38
https://hdl.handle.net/2318/1871678
https://hdl.handle.net/2318/1871678
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2474 (2008)
Proliferation of the pathogenic Plasmodium asexual blood stages in host erythrocytes requires an exquisite capacity to protect the malaria parasite against oxidative stress. This function is achieved by a complex antioxidant defence system composed o
Externí odkaz:
https://doaj.org/article/e48728d037a549cea859edf74ce3621a
Autor:
Stefan Rahlfs, Anna Katharina Schuh, Franziska Mohring, Stine Weder, Katja Becker, Stanislaw J. Gabryszewski, Mahsa Rahbari, Kathrin Buchholz, David A. Fidock, Kim C. Heimsch
Studying redox metabolism in malaria parasites is of great interest for understanding parasite biology, parasite-host interactions, and mechanisms of drug action. Genetically encoded fluorescent redox sensors have recently been described as powerful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521f573cbfc08ac11e6b4ffc7844618a
https://europepmc.org/articles/PMC6402873/
https://europepmc.org/articles/PMC6402873/
Autor:
Rui Moreira, Filipa P. da Cruz, Michael Hannus, Kathrin Buchholz, Miguel Prudêncio, Maria M. Mota, Maria J. Lafuente-Monasterio, Matthias Marti, Cecilie Martin, Francisco-Javier Gamo, Birte Sönnichsen, Tiago Rodrigues
Publikováno v:
The Journal of Infectious Diseases
The Journal of Infectious Diseases, 205 (8)
Journal of Infectious Diseases
Journal of Infectious Diseases; Vol 205
The Journal of Infectious Diseases, 205 (8)
Journal of Infectious Diseases
Journal of Infectious Diseases; Vol 205
Plasmodium parasites undergo a clinically silent and obligatory developmental phase in the host's liver cells before they are able to infect erythrocytes and cause malaria symptoms. To overcome the scarcity of compounds targeting the liver stage of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb88b98c94c9215e92cb01f304ba839
http://doc.rero.ch/record/291068/files/jis184.pdf
http://doc.rero.ch/record/291068/files/jis184.pdf
Autor:
Thomas A. Burke, Roger C. Wiegand, Kim C. Williamson, Dyann F. Wirth, Kathrin Buchholz, Matthias Marti
Publikováno v:
The Journal of Infectious Diseases
A major goal of the worldwide malaria eradication program is the reduction and eventual elimination of malaria transmission. All currently available antimalarial compounds were discovered on the basis of their activity against the asexually reproduci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53aeb02f728981d46a43b86a48e2ff9
https://doi.org/10.1093/infdis/jir037
https://doi.org/10.1093/infdis/jir037
Autor:
Kathrin Buchholz, R. Luise Krauth-Siegel, Marcelo A. Comini, Dirk Wissenbach, Stephan Gromer, R. Heiner Schirmer
Publikováno v:
Molecular and Biochemical Parasitology. 160:65-69
Methylene blue (MB) is known to have trypanocidal activity. We tested the interactions of MB with a number of trypanosomatid-specific molecules of the antioxidant metabolism. At pH 7, trypanothione and other (di)thiols were oxidized to disulfides by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8303c48a9e4a51fc9903c884dfb7b4b2
https://doi.org/10.1016/j.molbiopara.2008.03.006
https://doi.org/10.1016/j.molbiopara.2008.03.006
Publikováno v:
Nature protocols
Conversion from asexual proliferation to sexual differentiation initiates the production of the gametocyte, which is the malaria parasite stage required for human-to-mosquito transmission. This protocol describes an assay designed to probe the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be4af56ebbf390762602e489e973ff2
https://pubmed.ncbi.nlm.nih.gov/26134953
https://pubmed.ncbi.nlm.nih.gov/26134953
Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection
Autor:
Danny A. Milner, Karl B. Seydel, Terrie E. Taylor, Nicolas M. B. Brancucci, Kathrin Buchholz, Siyuan Ma, Vagheesh M. Narasimhan, Regina Joice, Natasha S. Barteneva, Curtis Huttenhower, Till S. Voss, Karell G. Pellé, Keunyoung Oh, Matthias Marti, Ken Ketman
Publikováno v:
Genome Medicine
GENOME MEDICINE
Genome medicine
GENOME MEDICINE
Genome medicine
Background During intra-erythrocytic development, late asexually replicating Plasmodium falciparum parasites sequester from peripheral circulation. This facilitates chronic infection and is linked to severe disease and organ-specific pathology includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a500e42d170573e09c54a0f7f8ef00
https://edoc.unibas.ch/36605/
https://edoc.unibas.ch/36605/
Autor:
Elizabeth S. Egan, Manoj T. Duraisingh, Prashant Prabhat, Matthias Marti, Natasha S. Barteneva, Kathrin Buchholz, Ivan A. Vorobjev, Kenneth James Ketman
Publikováno v:
Malaria Journal, Vol 11, Iss 1, p 312 (2012)
Malaria Journal
Malaria Journal
Background Malaria remains a major cause of morbidity and mortality worldwide. Flow cytometry-based assays that take advantage of fluorescent protein (FP)-expressing malaria parasites have proven to be valuable tools for quantification and sorting of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe9b414034cd7b64b01272ffac6e1a0
http://www.malariajournal.com/content/11/1/312
http://www.malariajournal.com/content/11/1/312