Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kathrin, Pfeifer"'
Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival
Autor:
Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Mats Bemark, Patricia Mendoza-Garcia, Ruth H. Palmer
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 8 (2022)
Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/C
Externí odkaz:
https://doaj.org/article/07bf718e76ba44b88c1bdc5f2a42c7cc
Autor:
Hao Huang, Alexander Gont, Lynn Kee, Ruben Dries, Kathrin Pfeifer, Bandana Sharma, David N. Debruyne, Matthew Harlow, Satyaki Sengupta, Jikui Guan, Caleb M. Yeung, Wenchao Wang, Bengt Hallberg, Ruth H. Palmer, Meredith S. Irwin, Rani E. George
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109363- (2021)
Summary: Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclea
Externí odkaz:
https://doaj.org/article/4d42e574c9364bf5b62295a7b9c9fc0b
Autor:
Patricia Mendoza-García, Fredrik Hugosson, Mahsa Fallah, Michael L Higgins, Yasuno Iwasaki, Kathrin Pfeifer, Georg Wolfstetter, Gaurav Varshney, Dmitry Popichenko, J Peter Gergen, Korneel Hens, Bart Deplancke, Ruth H Palmer
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006617 (2017)
The Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) plays a critical role in the specification of founder cells (FCs) in the Drosophila visceral mesoderm (VM) during embryogenesis. Reporter gene and CRISPR/Cas9 deletion analysis revea
Externí odkaz:
https://doaj.org/article/d0f619aa1f4840e6aaa06ec916cd4948
Autor:
Jikui Guan, Ganesh Umapathy, Yasuo Yamazaki, Georg Wolfstetter, Patricia Mendoza, Kathrin Pfeifer, Ateequrrahman Mohammed, Fredrik Hugosson, Hongbing Zhang, Amy W Hsu, Robert Halenbeck, Bengt Hallberg, Ruth H Palmer
Publikováno v:
eLife, Vol 4 (2015)
Aberrant activation of anaplastic lymphoma kinase (ALK) has been described in a range of human cancers, including non-small cell lung cancer and neuroblastoma (Hallberg and Palmer, 2013). Vertebrate ALK has been considered to be an orphan receptor an
Externí odkaz:
https://doaj.org/article/2218d2495c9e4a558a123f4bb2b6ef16
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96702 (2014)
In this study, we aimed to identify molecular mechanisms involved in the specification of the 4d (mesentoblast) lineage in Platynereis dumerilii. We employ RT-PCR and in situ hybridization against the Platynereis dumerilii twist homolog (Pdu-twist) t
Externí odkaz:
https://doaj.org/article/4fc3bd32ad5b475a85659474b1b02d21
Autor:
Steffen Franz, Mareva Ciatipis, Kathrin Pfeifer, Birthe Kierdorf, Beatrice Sandner, Ulrich Bogdahn, Armin Blesch, Beate Winner, Norbert Weidner
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102896 (2014)
After spinal cord injury, transected axons fail to regenerate, yet significant, spontaneous functional improvement can be observed over time. Distinct central nervous system regions retain the capacity to generate new neurons and glia from an endogen
Externí odkaz:
https://doaj.org/article/182797d095e54d88890eb080c27d598d
Autor:
Kathrin Pfeifer, Ruth H. Palmer, Georg Wolfstetter, Sa Chen, Anne Uv, Patricia Mendoza-Garcia, Tafheem A Masudi, Mattias Backman, Ezgi Uçkun, SK Sukumar, Gaurav K. Varshney, Hannah Sonnenberg
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase of the insulin receptor super-family that functions as oncogenic driver in a range of human cancers such as neuroblastoma. In order to investigate mechanisms underlying Alk oncogenic sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2ebf4b690a88dbfacf6a33b447995f
https://doi.org/10.1038/s41598-020-70890-6
https://doi.org/10.1038/s41598-020-70890-6
Autor:
Lynn Kee, Jikui Guan, Bandana Sharma, Kathrin Pfeifer, Rani E. George, Ruth H. Palmer, Ruben Dries, Satyaki Sengupta, Wenchao Wang, Alexander Gont, Matthew L. Harlow, Caleb M. Yeung, David Debruyne, Hao Huang, Bengt Hallberg, Meredith S. Irwin
Publikováno v:
Cell reports
Cell Reports, Vol 36, Iss 2, Pp 109363-(2021)
Cell Reports, Vol 36, Iss 2, Pp 109363-(2021)
SUMMARY Although activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ~10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d457a5a4675766e50fe43205b1844a
http://europepmc.org/articles/PMC8328392
http://europepmc.org/articles/PMC8328392
Autor:
Wasi Alam, Marcus Borenäs, Ganesh Umapathy, Bengt Hallberg, Patricia Mendoza-Garcia, Joanna Szydzik, Kathrin Pfeifer, Ruth H. Palmer, Joachim T. Siaw, Diana Cervantes-Madrid, Jikui Guan, Dan E. Lind
Publikováno v:
Cancer Research. 80:A36-A36
Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK), has been identified as a fusion partner in a diverse variety of translocation events resulting in oncogenic signaling in many different cancer types. In tumors w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96c72dd1caa0491bcb1515c1a57792c
https://doi.org/10.1158/1538-7445.pedca19-a36
https://doi.org/10.1158/1538-7445.pedca19-a36
Autor:
Georg, Wolfstetter, Ina, Dahlitz, Kathrin, Pfeifer, Uwe, Töpfer, Joscha Arne, Alt, Daniel Christoph, Pfeifer, Reinhard, Lakes-Harlan, Stefan, Baumgartner, Ruth H, Palmer, Anne, Holz
Publikováno v:
Development (Cambridge, England). 146(2)
Basement membranes (BMs) are specialized layers of extracellular matrix (ECM) mainly composed of Laminin, type IV Collagen, Perlecan and Nidogen/entactin (NDG). Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31f9c14a82d9cc73a89d9649622ef106
https://pubmed.ncbi.nlm.nih.gov/30567930
https://pubmed.ncbi.nlm.nih.gov/30567930