Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Kathlynn C. Brown"'
Autor:
Curtis A. Allred, Claire Gormley, Indu Venugopal, Shunzi Li, Michael J. McGuire, Kathlynn C. Brown
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Peptide modification is used to optimize the transport of saporin specifically to cancer cells in vitro and in vivo, where it exerts anti-cancer actions.
Externí odkaz:
https://doaj.org/article/af0f56e6289749cea0b0fa9a291b745b
Publikováno v:
BioTechniques, Vol 58, Iss 2, Pp 81-84 (2015)
Amplification bias is a major hurdle in phage display protocols because it imparts additional, unintended selection pressure beyond binding to the desired target. One potential source of amplification bias is the inherent lack of codon optimization t
Externí odkaz:
https://doaj.org/article/abaefbbfa3784e2eac42332583c97299
Autor:
Kathlynn C. Brown, Xiankai Sun, Tsukasa Oyama, Ying-Horng Liu, Mai Lin, Michael J. McGuire, Shunzi Li
Supplementary Data from Synthesis and characterization of a high-affinity αvβ6-specific ligand for in vitro and in vivo applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a31a81e6dacf0952a3cc259dbb1520
https://doi.org/10.1158/1535-7163.22485057.v1
https://doi.org/10.1158/1535-7163.22485057.v1
Autor:
Kathlynn C. Brown, Xiankai Sun, Tsukasa Oyama, Ying-Horng Liu, Mai Lin, Michael J. McGuire, Shunzi Li
The αvβ6 integrin is an attractive therapeutic target for several cancers due to its role in metastasis and its negligible expression in normal tissues. We previously identified a peptide from a phage-displayed peptide library that binds specifical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e227944f53c7b01f5642bc3f0e63a43
https://doi.org/10.1158/1535-7163.c.6531753
https://doi.org/10.1158/1535-7163.c.6531753
Autor:
Kathlynn C. Brown, Michael J. McGuire, Jack A. Roth, Ignacio I. Wistuba, Xian-Jin Xie, Aihua Bian, Ying-Horng Liu, Ludmila Prudkin, Kausar N. Samli, Anissa N. Elayadi
The development of new modes of diagnosis and targeted therapy for lung cancer is dependent on the identification of unique cell surface features on cancer cells and isolation of reagents that bind with high affinity and specificity to these biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150532230b89ea370dd72b217764356b
https://doi.org/10.1158/0008-5472.c.6495483.v1
https://doi.org/10.1158/0008-5472.c.6495483.v1
Autor:
Kathlynn C. Brown, Michael J. McGuire, Jack A. Roth, Ignacio I. Wistuba, Xian-Jin Xie, Aihua Bian, Ying-Horng Liu, Ludmila Prudkin, Kausar N. Samli, Anissa N. Elayadi
Supplementary Figures 1-6 from A Peptide Selected by Biopanning Identifies the Integrin αvβ6 as a Prognostic Biomarker for Nonsmall Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e23daa2b6dbba53e5a993987c089c88
https://doi.org/10.1158/0008-5472.22367256.v1
https://doi.org/10.1158/0008-5472.22367256.v1
Autor:
Kathlynn C. Brown, Michael J. McGuire, Jack A. Roth, Ignacio I. Wistuba, Xian-Jin Xie, Aihua Bian, Ying-Horng Liu, Ludmila Prudkin, Kausar N. Samli, Anissa N. Elayadi
Supplementary Figure Legends 1-6 from A Peptide Selected by Biopanning Identifies the Integrin αvβ6 as a Prognostic Biomarker for Nonsmall Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52082220b4e0dd398b073d1623e6bfb2
https://doi.org/10.1158/0008-5472.22367259.v1
https://doi.org/10.1158/0008-5472.22367259.v1
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72938 (2013)
One method for improving cancer treatment is the use of nanoparticle drugs functionalized with targeting ligands that recognize receptors expressed selectively by tumor cells. In theory such targeting ligands should specifically deliver the nanoparti
Externí odkaz:
https://doaj.org/article/a35ee1cd125a432fb113d871a0195479
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A648-A648
BackgroundImmune checkpoint inhibitors (CIs) have emerged as a revolutionary treatment for several cancer types. Despite significant improvement in prognosis for some patients, there are associated challenges. CIs do not work well on immune-cold tumo
Autor:
Curtis A. Allred, Claire Gormley, Indu Venugopal, Kathlynn C. Brown, Susan Li, Michael J. McGuire, Kevin J. Luebke
Publikováno v:
Molecular Cancer Research. 18:B21-B21
Antibodies and peptides directed against the switch regions of RAS can disrupt interactions with its downstream effector proteins, blocking downstream protumorigenic signaling. However, these biologic therapies are unable to reach the intracellular e