Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kathleen W. Clancy"'
Autor:
Mark S. Tichenor, John J. M. Wiener, Navin L. Rao, Genesis M. Bacani, Jianmei Wei, Charlotte Pooley Deckhut, J. Kent Barbay, Kevin D. Kreutter, Leon Chang, Kathleen W. Clancy, Heather E. Murrey, Weixue Wang, Kay Ahn, Michael Huber, Elizabeth Rex, Kevin J. Coe, Jiejun Wu, Haopeng Rui, Kia Sepassi, Marcello Gaudiano, Mariette Bekkers, Ivo Cornelissen, Kathryn Packman, Mark Seierstad, Christos Xiouras, Scott D. Bembenek, Richard Alexander, Cynthia Milligan, Sriram Balasubramanian, Alec D. Lebsack, Jennifer D. Venable, Ulrike Philippar, James P. Edwards, Gavin Hirst
Publikováno v:
Journal of Medicinal Chemistry. 65:14326-14336
Bruton's tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in leukocytes. Pharmacological inhibition of BTK has been shown to be effective in treating hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b6932f837c19dc6e82c72e8534354a
https://doi.org/10.1021/acs.jmedchem.2c01026
https://doi.org/10.1021/acs.jmedchem.2c01026
Autor:
Venkataraman Subramanian, Aaron Muth, Sangram S. Parelkar, Mitesh Nagar, Philip S. Kerry, Kathleen W. Clancy, Hema Srinath, Paul A. McEwan, Paul R. Thompson, Edward Beaumont
Publikováno v:
Journal of Medicinal Chemistry. 60:3198-3211
Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be critical for elucidatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b77dfe7b0e745cc01ee7ec0fb4140
https://doi.org/10.1021/acs.jmedchem.7b00274
https://doi.org/10.1021/acs.jmedchem.7b00274
Autor:
Venkataraman Subramanian, Hannah Nguyen, Kathleen W. Clancy, Yuewei Qian, Anna-Maria Russell, Robert M. Campbell, Paul R. Thompson
Publikováno v:
ACS chemical biology. 12(6)
Posttranslational modifications of histone tails are a key contributor to epigenetic regulation. Histone H3 Arg26 and Lys27 are both modified by multiple enzymes, and their modifications have profound effects on gene expression. Citrullination of H3R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172923ac7cf7b7baba084aa61dcb5fa3
https://pubmed.ncbi.nlm.nih.gov/28485572
https://pubmed.ncbi.nlm.nih.gov/28485572
Protein citrullination is a post-translational modification of arginine that is catalyzed by the Protein Arginine Deiminase (PAD) family of enzymes. Aberrantly increased citrullination is associated with a host of inflammatory diseases and cancer and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbfbd9434de7bebcd6fca8cb192e185
https://europepmc.org/articles/PMC4731267/
https://europepmc.org/articles/PMC4731267/
Autor:
Daniel J. Slade, Daniel M. Lewallen, Venkataraman Subramanian, Paul R. Thompson, Kathleen W. Clancy, Kevin L. Bicker, Jeremy Sokolove, Christina J. Dreyton, Eranthie Weerapana, Julianne Martell
Publikováno v:
ACS Chemical Biology
Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and are routinely used for disease diagnosis. Protein citrullination is also increased in cancer and other autoimmune disorders, suggesting that citrullinated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f8d2f715c40bc1b53d810cb170ee26
https://pubmed.ncbi.nlm.nih.gov/26360112
https://pubmed.ncbi.nlm.nih.gov/26360112
Autor:
Sangwon F. Kim, Vassilios Papadopoulos, Lynda D. Hester, Solomon H. Snyder, Stanley E. Patterson, Kathleen W. Clancy, Jaime H. Cheah
Publikováno v:
Neuron. 51:431-440
SummaryDexras1 is a 30 kDa G protein in the Ras subfamily whose discovery was based on its pronounced inducibility by the glucocorticoid dexamethasone. It binds to neuronal nitric oxide synthase (nNOS) via the adaptor protein CAPON, eliciting S-nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40044b74b3ab503a3670a99a249925e
https://doi.org/10.1016/j.neuron.2006.07.011
https://doi.org/10.1016/j.neuron.2006.07.011
Autor:
Xiangqian Hu, Dewey G. McCafferty, Kathleen W. Clancy, Hao Hu, Weitao Yang, Jeffrey A. Melvin
Publikováno v:
Journal of the American Chemical Society. 133(3)
Many Gram-positive pathogens possess external pili or fimbriae with which they adhere to host cells during the infection process. Unusual dual intramolecular isopeptide bonds between Asn and Lys side chains within the N-terminal and C-terminal domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4150243f873db3c5aded7c24b4d12f03
https://pubmed.ncbi.nlm.nih.gov/21142157
https://pubmed.ncbi.nlm.nih.gov/21142157
Publikováno v:
Biopolymers. 94(4)
Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb5c15c3f41cbfcb82f1d87541d2e30
https://pubmed.ncbi.nlm.nih.gov/20593474
https://pubmed.ncbi.nlm.nih.gov/20593474
Publikováno v:
Biopolymers. 94:681-681
Gram-positive bacteria pose a serious healthcare threat, The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29291f8291a3979bcd7c91a58a1faf9a
https://doi.org/10.1002/bip.21529
https://doi.org/10.1002/bip.21529