Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Kathleen W Kinnally"'
Autor:
Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily H-Y Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin
Publikováno v:
eLife, Vol 2 (2013)
A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Ba
Externí odkaz:
https://doaj.org/article/05dd5d4356784fc28183de961bc98086
Autor:
Herbert H. Samuels, Kathleen W. Kinnally, Sonia Martinez-Caballero, Anthony I. Vulin, Dangsheng Li, Jerome C. Nwachukwu, Sharmistha Das
We previously reported that amino acids 20 to 50 of nuclear receptor interacting factor-3 mediates rapid apoptosis in breast cancer cell lines but not in cells derived from other tissues. We refer to this short region as death domain-1 (DD1). Small i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7765752130fde6e12388b34c4988de35
https://doi.org/10.1158/0008-5472.c.6496497.v1
https://doi.org/10.1158/0008-5472.c.6496497.v1
Autor:
Herbert H. Samuels, Kathleen W. Kinnally, Sonia Martinez-Caballero, Anthony I. Vulin, Dangsheng Li, Jerome C. Nwachukwu, Sharmistha Das
Supplementary Movie 1 from The Nuclear Receptor Interacting Factor-3 Transcriptional Coregulator Mediates Rapid Apoptosis in Breast Cancer Cells through Direct and Bystander-Mediated Events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00db696571c27ee3d118d2e01d4a7116
https://doi.org/10.1158/0008-5472.22370700.v1
https://doi.org/10.1158/0008-5472.22370700.v1
Publikováno v:
Mitochondrion. 12:14-23
Mitochondria communicate with the rest of the cell through channels located in their inner and outer membranes. Most of the time, the message is encoded by the flow of anions and cations e.g., through VDAC and PTP, respectively. However, proteins are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae87f85ab7fa3abff99e31c1c650b6f
https://doi.org/10.1016/j.mito.2011.03.003
https://doi.org/10.1016/j.mito.2011.03.003
Publikováno v:
Journal of Biological Chemistry. 286:21324-21329
Heart mitochondria utilize multiple Ca(2+) transport mechanisms. Among them, the mitochondrial ryanodine receptor provides a fast Ca(2+) uptake pathway across the inner membrane to control "excitation and metabolism coupling." In the present study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffbf2172bcee7920cadd0cc4c0d01f7
https://doi.org/10.1074/jbc.c111.245597
https://doi.org/10.1074/jbc.c111.245597
Mitochondrial Apoptosis-Induced Channel (MAC) Function Triggers a Bax/Bak-Dependent Bystander Effect
Autor:
Kathleen W. Kinnally, Shin Young Ryu, Jennifer K. Lue, Pablo M. Peixoto, Jill C. Sible, Brian N. Wroble
Publikováno v:
The American Journal of Pathology. 178:48-54
Collateral spread of apoptosis to nearby cells is referred to as the bystander effect, a process that is integral to tissue homeostasis and a challenge to anticancer therapies. In many systems, apoptosis relies on permeabilization of the mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7217f658611c499867eeb69a073426
https://doi.org/10.1016/j.ajpath.2010.11.014
https://doi.org/10.1016/j.ajpath.2010.11.014
Autor:
Laurent M. Dejean, Sonia Martinez-Caballero, Oscar Teijido, Shin Young Ryu, Pablo M. Peixoto, Kathleen W. Kinnally
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1797(6-7):1231-1238
Apoptosis is an elemental form of programmed cell death; it is fundamental to higher eukaryotes and essential to mechanisms controlling tissue homeostasis. Apoptosis is also involved in many pathologies including cancer, neurodegenerative diseases, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a480a86510b264002aa5ffb7d9f61be1
Publikováno v:
Journal of Bioenergetics and Biomembranes. 40:149-155
There is excellent agreement between the electrophysiological properties and the structure of the mitochondrial outer membrane protein, VDAC, ex vivo. However, the inference that the well-defined canonical "open" state of the VDAC pore is the normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c764d6890dadd06806cd422fd05353
https://doi.org/10.1007/s10863-008-9143-0
https://doi.org/10.1007/s10863-008-9143-0
Autor:
Kathleen W. Kinnally, Sharmistha Das, Anthony I. Vulin, Jerome C. Nwachukwu, Dangsheng Li, Sonia Martinez-Caballero, Herbert H. Samuels
Publikováno v:
Cancer Research. 67:1775-1782
We previously reported that amino acids 20 to 50 of nuclear receptor interacting factor-3 mediates rapid apoptosis in breast cancer cell lines but not in cells derived from other tissues. We refer to this short region as death domain-1 (DD1). Small i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b8a1e31863b14447bf30321f4db92d
https://doi.org/10.1158/0008-5472.can-06-4034
https://doi.org/10.1158/0008-5472.can-06-4034
Autor:
Kathleen W. Kinnally, Bruno Antonsson
Publikováno v:
Apoptosis. 12:857-868
The crucial step in the intrinsic, or mitochondrial, apoptotic pathway is permeabilization of the mitochondrial outer membrane. Permeabilization triggers release of apoptogenic factors, such as cytochrome c, from the mitochondrial intermembrane space
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727d1a3c9d864f88ce8b36e69585353b
https://doi.org/10.1007/s10495-007-0722-z
https://doi.org/10.1007/s10495-007-0722-z