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pro vyhledávání: '"Kathleen Tiefenwerth"'
Autor:
Kristin Anderson, Brittany Yearby, Susan Denton, Courtney D. DiNardo, Guillermo Garcia-Manero, Linda J. Paradiso, Teletha Gipson, Kathleen Tiefenwerth, Hagop M. Kantarjian, Thomas J. Myers, Hiroyuki Iwamura, Ricardo Delumpa, Christopher Loiselle, Naval Daver, Silvia Rivera, Hui Yang, Michele Rosner, Naveen Pemmaraju, Zhihong Fang, Elias Jabbour, Whitney Smith
Publikováno v:
Blood. 128:1640-1640
Inosine 5'- monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme that catalyzes de novo synthesis of the guanine nucleotide and is overexpressed in both hematologic and solid tumors. FF-10501-01 is a potent new competitive IMPDH inhibitor. W