Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kathleen T. Pagarigan"'
Autor:
James B. Machamer, Edwin J. Vazquez-Cintron, Mallory J. Stenslik, Kathleen T. Pagarigan, Aaron B. Bradford, Celinia A. Ondeck, Patrick M. McNutt
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionBotulinum neurotoxin (BoNT) causes neuroparalytic disease and death by blocking neuromuscular transmission. There are no specific therapies for clinical botulism and the only treatment option is supportive care until neuromuscular functio
Externí odkaz:
https://doaj.org/article/8a9f93deb0aa4fd4ad7ec9376ca356fa
Autor:
James B. Machamer, Edwin J. Vazquez-Cintron, Sean W. O’Brien, Kyle E. Kelly, Amber C. Altvater, Kathleen T. Pagarigan, Parker B. Dubee, Celinia A. Ondeck, Patrick M. McNutt
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-14 (2022)
Abstract Botulinum neurotoxins (BoNTs) are highly potent, select agent toxins that inhibit neurotransmitter release at motor nerve terminals, causing muscle paralysis and death by asphyxiation. Other than post-exposure prophylaxis with antitoxin, the
Externí odkaz:
https://doaj.org/article/217f4bf70c89403a831545108d977f5c
Autor:
Julia E. Morgan, Sara C. Wilson, Benjamin J. Travis, Kathryn H. Bagri, Kathleen T. Pagarigan, Hannah M. Belski, Cecelia Jackson, Kevin M. Bounader, Jessica M. Coppola, Eden N. Hornung, James E. Johnson, Hilary S. McCarren
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition. T
Externí odkaz:
https://doaj.org/article/82e115ebae2b479090b5715d10580dce
Autor:
Sarah E Wolfe, Kevin M. Bounader, Kathleen T Pagarigan, Patrick M. McNutt, Michael Adler, Shane A. Kasten, James P. Apland, James B. Machamer, Brittany M. Winner
Publikováno v:
Archives of Toxicology. 94:3877-3891
Organophosphorus (OP) compounds inhibit central and peripheral acetylcholinesterase (AChE) activity, overstimulating cholinergic receptors and causing autonomic dysfunction (e.g., bronchoconstriction, excess secretions), respiratory impairment, seizu
Autor:
Dominique L. Nguyen, Megan E Lyman, Marian R. Nelson, Tracey A. Hamilton, Sarah E Wolfe, Margaret M Eisen, Mark Mangkhalakhili, Kathleen T Pagarigan, Celinia A. Ondeck, Denise M. Kniffin, Patrick M. McNutt
Publikováno v:
Cornea. 39:640-648
Purpose Ocular exposure to sulfur mustard (SM) vapor causes acute loss of corneal endothelial cells (CECs). Persistent corneal endothelial pathologies are observed in eyes that do not recover from SM exposure, suggesting that endothelial toxicity con
Autor:
Hilary S. McCarren, Kevin M. Bounader, Julia E. Morgan, James E. Johnson, Benjamin J. Travis, Jessica M. Coppola, Kathleen T Pagarigan, Kathryn H. Bagri, Eden N. Hornung, Hannah M. Belski, Sara C. Wilson, Cecelia Jackson
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Frontiers in Neuroscience
Frontiers in Neuroscience
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus (SE). Current guidelines for treatment of NA-induced SE only include prehospital benzodiazepines, which may not fully resolve this life-threatening condition. T
Autor:
James B, Machamer, James P, Apland, Brittany M, Winner, Sarah E, Wolfe, Kathleen T, Pagarigan, Kevin M, Bounader, Shane A, Kasten, Michael, Adler, Patrick M, McNutt
Publikováno v:
Archives of toxicology. 94(11)
Organophosphorus (OP) compounds inhibit central and peripheral acetylcholinesterase (AChE) activity, overstimulating cholinergic receptors and causing autonomic dysfunction (e.g., bronchoconstriction, excess secretions), respiratory impairment, seizu
Autor:
Kathleen T Pagarigan, James B. Machamer, Patrick M. McNutt, Edwin J. Vazquez-Cintron, Brittany M. Winner, Kyle E.M. Kelly, Celinia A. Ondeck, M Ross Pennington, Paige M. Bodner
Publikováno v:
JCI Insight. 5
Botulinum neurotoxins (BoNTs) are potent neuroparalytic toxins that cause mortality through respiratory paralysis. The approved medical countermeasure for BoNT poisoning is infusion of antitoxin immunoglobulins. However, antitoxins have poor therapeu
Autor:
James B. Machamer, Edwin Cintron-Vasquez, Patrick M. McNutt, Celinia A. Ondeck, Brittany M. Winner, Cecilia Phung, Kathleen T Pagarigan
Publikováno v:
Toxicon. 156:S71
Autor:
Edwin J. Vazquez-Cintron, James B. Machamer, Celinia A. Ondeck, Kathleen T Pagarigan, Brittany M. Winner, Patrick M. McNutt, Cecilia Phung
Publikováno v:
Toxicon. 156:S112