Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Kathleen T. Gallagher"'
1
Data from Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib
Autor: Edgar R. Wood, Lisa Shewchuk, Anne T. Truesdale, H. Luke Carter, Ermias Woldu, Kathleen T. Gallagher, Glenn Spehar, David Rusnak, Krystal Alligood, Louann Cable, Tona M. Gilmer
The goal of this study was to characterize the effects of non–small cell lung carcinoma (NSCLC)-associated mutations in epidermal growth factor receptor (EGFR/ErbB1) and HER2 (ErbB2) on interactions with the dual tyrosine kinase inhibitor lapatinib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4634a8f47176a77086f78bb49fe819c
https://doi.org/10.1158/0008-5472.c.6497225
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3
Identification and Implementation of Biocatalytic Transformations in Route Discovery: Synthesis of Chiral 1,3-Substituted Cyclohexanone Building Blocks
Autor: Alba Diaz-Rodriguez, Gheorghe-Doru Roiban, Kristin K. Brown, Kathleen T. Gallagher, Timin Hadi, Diluar Khan, Markus Schober, Radka Snajdrova, Douglas E. Fuerst, James Patrick Morrison, Michael R. Webb, Justin M. Kaplan
Publikováno v: Organic Process Research & Development. 22:871-879
Several biocatalytic approaches for the preparation of optically pure methyl 3-oxocyclohexanecarboxylates (S)-, (R)-1 and 3-oxocyclohexanecarbonitriles (S)-, (R)-2 have been successfully demonstrated. Screening of reaction-focused enzyme collections
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98b4767186d7e263b54c13915f564713
https://doi.org/10.1021/acs.oprd.8b00139
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4
A Luciferase Reporter Gene System for High-Throughput Screening of γ-Globin Gene Activators
Autor: Kathy Johnson, Zining Wu, Robert Silvers, Monica N. Montoute, Hu Li, Wensheng Xie, Quinn Lu, Michael T. Ouellette, Kathleen T. Gallagher
Publikováno v: Methods in Molecular Biology ISBN: 9781493936717
Luciferase reporter gene assays have long been used for drug discovery due to their high sensitivity and robust signal. A dual reporter gene system contains a gene of interest and a control gene to monitor non-specific effects on gene expression. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9340c327d1c6329439e571b3004e2da9
https://doi.org/10.1007/978-1-4939-3673-1_14
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5
Optimized procedures for producing biologically active chemokines
Autor: John J. Kerrigan, Dulcie B. Schmidt, James J. Foley, Abby J. Sukman, Tia Lewis, Patrick McDevitt, Kathleen T. Gallagher, Kyung O. Johanson, Robert S. Ames, James A. Fornwald, Taylor L. Graham, Matthew C. Burns, Quinn Lu, Xiaoyan Tang, Gerald E. Hunsberger
Publikováno v: Protein Expression and Purification. 65:251-260
We describe here two strategies to produce biologically active chemokines with authentic N-terminal amino acid residues. The first involves producing the target chemokine with an N-terminal 6×His-SUMO tag in Escherichia coli as inclusion bodies. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951418dee127686dd1f484c032678731
https://doi.org/10.1016/j.pep.2009.01.017
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6
Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib
Autor: Ermias Woldu, Lisa M. Shewchuk, Kathleen T. Gallagher, David W. Rusnak, Krystal J. Alligood, Tona M. Gilmer, LouAnn Cable, H. Luke Carter, Glenn M. Spehar, Edgar R. Wood, Anne T. Truesdale
Publikováno v: Cancer Research. 68:571-579
The goal of this study was to characterize the effects of non–small cell lung carcinoma (NSCLC)-associated mutations in epidermal growth factor receptor (EGFR/ErbB1) and HER2 (ErbB2) on interactions with the dual tyrosine kinase inhibitor lapatinib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbddcc529d5593323a8303425b8c76e7
https://doi.org/10.1158/0008-5472.can-07-2404
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7
Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils
Autor: Julie A. Abrahamson, Kathleen T. Gallagher, Bruce S. Bochner, Stephen D. Holmes, John R. White, Kristine K. Kikly, Connie L. Erickson-Miller, Karla J. D’Alessio, Hiroshi Tachimoto, Paul R. Murdock, Sylvie D. Freeman, Kong B. Tan, Robert P. Schleimer
Publikováno v: Journal of Allergy and Clinical Immunology. 105:1093-1100
Background: Eosinophils, basophils, and mast cells are believed to be the central tenet cells in allergic conditions including allergic rhinitis, asthma, and eczema. The molecular mechanisms underlying the recruitment of these cells to sites of aller
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8810ad5d99c5f6db486cd04757bd0e
https://doi.org/10.1067/mai.2000.107127
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8
Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine
Autor: Joel S. Parker, Rakesh Kumar, Peter F. Lebowitz, Ashley M. Hughes, Joanna D. Holbrook, Kathleen T. Gallagher, Wendy S. Halsey, Victor J. Weigman
Publikováno v: Journal of Translational Medicine, Vol 9, Iss 1, p 119 (2011)
Journal of Translational Medicine
Background Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries. Methods Here, we report a genetic characterization of 50 gastric adeno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8249e625965dc7c5f6ebe41ff88c1d7
http://www.translational-medicine.com/content/9/1/119
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9
High-yield production and characterization of biologically active GST-tagged human topoisomerase IIα protein in insect cells for the development of a high-throughput assay
Autor: Andrew J. Theobald, Pan F. Chan, Namir J. Hassan, Kathleen T. Gallagher, Delfina C. Segura, Daniel Thomas, Praveen Kumar Singh, Maria-Jesus Vazquez, Martin Hibbs
Publikováno v: Protein expression and purification. 76(2)
DNA topoisomerase type II enzymes are well-validated targets of anti-bacterial and anti-cancer compounds. In order to facilitate discovery of these types of inhibitors human topoisomerase II in vitro assays can play an important role to support drug
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f608b96fc766d891436de8729ac7cbe3
https://pubmed.ncbi.nlm.nih.gov/20709174
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