Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kathleen Spring"'
Autor:
Blanka Halamoda-Kenzaoui, Robert Geertsma, Joost Pouw, Adriele Prina-Mello, Moreno Carrer, Matthias Roesslein, Adrienne Sips, Klaus Michael Weltring, Kathleen Spring, Susanne Bremer-Hoffmann
Publikováno v:
Drug Delivery and Translational Research. 12:2145-2156
The identification of regulatory challenges for nanotechnology-enabled health products, followed by discussions with the involved stakeholders, is the first step towards a strategic planning of how such challenges can be successfully addressed in the
Autor:
John Stagg, Anne-Marie Mes-Masson, Diane Provencher, Cécile Le Page, Kurosh Rahimi, Thomas Karn, Benjamin Haibe-Kains, Deena M.A. Gendoo, Gregory M. Chen, Joshy George, Isabelle Cousineau, Guillaume Chouinard, Sandra Pommey, Kathleen Spring, Martin Turcotte
Supplementary Figures S1-S8. Suppl. Fig. S1. Meta-analysis of CD73 and CD39 in ovarian cancer gene expression datasets. Suppl. Fig. S2. CD73 and CD8 staining in high grade serous ovarian cancer. Suppl. Fig. S3. Flow cytometry analysis of CD73 express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13894ea1c2fe935b830ba2710cb26abd
https://doi.org/10.1158/0008-5472.22407746
https://doi.org/10.1158/0008-5472.22407746
Autor:
John Stagg, Anne-Marie Mes-Masson, Diane Provencher, Cécile Le Page, Kurosh Rahimi, Thomas Karn, Benjamin Haibe-Kains, Deena M.A. Gendoo, Gregory M. Chen, Joshy George, Isabelle Cousineau, Guillaume Chouinard, Sandra Pommey, Kathleen Spring, Martin Turcotte
The cell surface nucleotidase CD73 is an immunosuppressive enzyme involved in tumor progression and metastasis. Although preclinical studies suggest that CD73 can be targeted for cancer treatment, the clinical impact of CD73 in ovarian cancer remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ba56d9a05cb073cb229c6ff75d1dab
https://doi.org/10.1158/0008-5472.c.6507374.v1
https://doi.org/10.1158/0008-5472.c.6507374.v1
Publikováno v:
Drug Delivery and Translational Research. 12:2039-2041
Publikováno v:
Methods in enzymology. 629
CD73 is a membrane-anchored ectoenzyme that degrades extracellular AMP into adenosine, a potent immunosuppressive factor. In physiological conditions, induction of the CD73-adenosine pathway acts as natural feedback mechanism to prevent excessive imm
CD73 is a membrane-anchored ectoenzyme that degrades extracellular AMP into adenosine, a potent immunosuppressive factor. In physiological conditions, induction of the CD73-adenosine pathway acts as natural feedback mechanism to prevent excessive imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88a6241abadc35af35d8265a40c85ce0
https://doi.org/10.1016/bs.mie.2019.10.007
https://doi.org/10.1016/bs.mie.2019.10.007
Publikováno v:
Cellular Signalling. 26:1283-1293
The protein tyrosine phosphatase DEP-1/PTPRJ positively regulates Src family kinases and critical biological functions in endothelial and hematopoietic cells. Phosphorylation of DEP-1 on Y1311/Y1320 mediates the association and activation of Src, and
Publikováno v:
International Journal of Cancer. 134:1466-1473
CD73 is an ecto-nucleotidase overexpressed in various types of tumors that catabolizes the generation of extracellular adenosine, a potent immunosuppressor. We and others have shown that targeted blockade of CD73 can rescue anti-tumor T cells from th
Autor:
Line Lapointe, Isabelle Royal, Mounib Elchebly, Simon Langlois, Kathleen Spring, Catherine Chabot, Nguyen Thu Ngan Trinh, Christine Caron, Jagoda K. Hebda, Julie Gavard
Publikováno v:
Blood. 120:2745-2756
DEP-1/CD148 is a receptor-like protein tyrosine phosphatase with antiproliferative and tumor-suppressive functions. Interestingly, it also positively regulates Src family kinases in hematopoietic and endothelial cells, where we showed it promotes VE-