Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kathleen S. Zandi"'
Autor:
Sandra A. Miller, Anne E. Reed-Hagen, Thomas N. O'Connell, Suzanne S. Krueger, R. Scott Obach, Jotham Wadsworth Coe, Kathleen S. Zandi, Beth J. Obach
Publikováno v:
Drug Metabolism and Disposition. 34:121-130
The metabolism and disposition of varenicline (7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine), a partial agonist of the nicotinic acetylcholine receptor for the treatment of tobacco addiction, was examined in rats, mice, monkeys,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e0f1c4f4cde48504443bb64f8bf029
https://doi.org/10.1124/dmd.105.006767
https://doi.org/10.1124/dmd.105.006767
Autor:
Kathleen S. Zandi, William Kissel, Brian M. Andresen, Chiu Charles K, John Charles Kath, David C. Whritenour, Matthew Frank Brown, Tung Le, Z. Jane Li, Eric Dias, Richard A. Buzon, Michel Couturier, Bryan Li, John L. Tucker, V. John Jasys, Joanna Teresa Negri, Poss Christopher Stanley, Frank J. Urban
Publikováno v:
Organic Process Research & Development. 9:466-471
Process development for the synthesis of 2-quinoxalinecarboxamide, N-[(1S,2S,4R)-4-(aminocarbonyl)-1-[(3-fluorophenyl)methyl]-2,7-dihydroxy-7-methyloctyl] is described. An optimized and streamlined process starting from lactone 2 was developed: Lacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bfdf67bd0fea0a89f37efcd9381a33b
https://doi.org/10.1021/op050059w
https://doi.org/10.1021/op050059w
Publikováno v:
Tetrahedron. 54:2289-2338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee96f250f469a57698dc7f43ed784aca
https://doi.org/10.1016/s0040-4020(97)10304-0
https://doi.org/10.1016/s0040-4020(97)10304-0
Publikováno v:
ChemInform. 23
New methodology is reported which enables reversal of regiochemistry in the Diels-Alder reaction. Esterification of 2-(β-hydroxyethyl)dimerhylsilydienes with common dienophiles followed by type 2 intramolecular Diels-Alder reaction results in format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3c483d9c8dd24a46da9816858f1816b
https://doi.org/10.1002/chin.199213087
https://doi.org/10.1002/chin.199213087
Publikováno v:
ChemInform. 22
Temporary union of diene and dienophile in the type 2 intramolecular Diels-Alder cycloaddition provides a general strategy for controlling both regio- and stereochemistry of the cycloaddition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28a092837c432d71c626a5d293947206
https://doi.org/10.1002/chin.199139134
https://doi.org/10.1002/chin.199139134
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a36beb5ea6d4859de5e4706eaaeed45c
https://doi.org/10.1002/chin.199635193
https://doi.org/10.1002/chin.199635193
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::760c177b9d2a1a45c757673d6f70dc0f
https://doi.org/10.1002/chin.199824237
https://doi.org/10.1002/chin.199824237
Publikováno v:
Tetrahedron Letters. 32:2715-2718
New methodology is reported which enables reversal of regiochemistry in the Diels-Alder reaction. Esterification of 2-(β-hydroxyethyl)dimerhylsilydienes with common dienophiles followed by type 2 intramolecular Diels-Alder reaction results in format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d37f4908e8bf37018bc7516dd9c00b6d
https://doi.org/10.1016/0040-4039(91)85066-e
https://doi.org/10.1016/0040-4039(91)85066-e
Publikováno v:
Tetrahedron Letters. 31:5885-5888
Temporary union of diene and dienophile in the type 2 intramolecular Diels-Alder cycloaddition provides a general strategy for controlling both regio- and stereochemistry of the cycloaddition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4acd303e6c9874be7ea03d8d761eca63
https://doi.org/10.1016/s0040-4039(00)97985-1
https://doi.org/10.1016/s0040-4039(00)97985-1
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 31(6)
The degradation product of ezlopitant was isolated from low specific activity material and identified by solution phase hydrogen/deuterium (H/D) exchange and electrospray ionization tandem mass spectrometry (ESI/MS/MS) to be an isopropyl peroxide ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e75967527171d4f2d90f60ec4c0efbd
https://pubmed.ncbi.nlm.nih.gov/12667937
https://pubmed.ncbi.nlm.nih.gov/12667937