Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kathleen S. Keegan"'
Autor:
Anella Yahiaoui, Sarah A Meadows, Rick A Sorensen, Zhi-Hua Cui, Kathleen S Keegan, Robert Brockett, Guang Chen, Christophe Quéva, Li Li, Stacey L Tannheimer
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171221 (2017)
Activated B-cell-like diffuse large B-cell lymphoma relies on B-cell receptor signaling to drive proliferation and survival. Downstream of the B-cell receptor, the key signaling kinases Bruton's tyrosine kinase and phosphoinositide 3-kinase δ offer
Externí odkaz:
https://doaj.org/article/a645d752f9ed4c7989cae7719beb9151
Autor:
Adrian Tomkinson, Gary Phillips, Jayaraman Chandrasekhar, Nicholas Alexander Till, Leena Patel, Jia Hao, Jennifer Treiberg, Joseph Therrien, Kathleen S. Keegan, Mary E. McGrath, Sedillo Kassandra F, Fatima Arjmand, Yelena Zherebina, Stephane Perreault, David Koditek, Clinton K. Matson, Eve-Irene Lepist
Publikováno v:
ACS Med Chem Lett
[Image: see text] A series of PI3Kβ selective inhibitors derived from a novel 4-(1H-benzo[d]imidazol-1-yl)quinoline chemotype has been rationally designed. Crucial to achieving the desired selectivity over the other class I PI3K isoforms, including
Autor:
Haritha Mathsyaraja, Benjamin Wolf, Chari Cortez, Adam Kashishian, Alison Karst, Madelyn Cueva, Min Wang, Kathleen S. Keegan, Jennifer Cain
Publikováno v:
Cancer Research. 82:2079-2079
Tumor cells employ mechanisms to evade anti-tumor immune responses that can include the downregulation or silencing of cytosolic nucleic acid sensing pathway components to dampen Type I IFN signaling. It has been documented that genomic instability a
Autor:
Clinton K. Matson, Thomas Kenney, Bart H. Steiner, Chloe R. Deodato, Anella Yahiaoui, Claudia A. Rubio, Julie T. Chan, Nevena Mollova, Kathleen S. Keegan, Chandrasekar Venkataramani
Publikováno v:
Cancer Research. 82:3696-3696
MCL1 is an anti-apoptotic member of the BCL2 family of proteins. These anti-apoptotic proteins prevent caspase-mediated cell apoptosis by binding to the pro-apoptotic proteins BIM, BAK and BAX, thereby inhibiting the formation of pores on the outer m
Autor:
Justin D. Lutz, Ting Wang, Roman Sakowicz, Weimei Xing, Adrian S. Ray, Gregg Czerwieniec, Albert Liclican, Bart Steiner, Kathleen S. Keegan, Joy Y. Feng, Katherine M. Brendza, Brian E. Schultz, Loredana Serafini
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1864:129531
Background Bruton's tyrosine kinase (BTK) is a key component of the B-cell receptor (BCR) pathway and a clinically validated target for small molecule inhibitors such as ibrutinib in the treatment of B-cell malignancies. Tirabrutinib (GS-4059/ONO-405
Autor:
Jia-Nan Gong, Angela Coxon, Sean Caenepeel, Cyril H. Benes, Andrew W. Roberts, Tao Osgood, Donia M Moujalled, Elaina Cajulis, Andrew H. Wei, Regina K. Egan, Mario G. Cardozo, Pedro J. Beltran, Liusheng Zhu, Marc Vimolratana, Sean P. Brown, Brian Lucas, Xin Huang, Gordon Moody, Paul E. Hughes, David C.S. Huang, Giovanna Pomilio, Joshua Taygerly, Jan Sun, Danny Chui, Leszek Poppe, Jude Canon, Douglas A. Whittington, Yunxiao Li, Manuel Zancanella, Nick A. Paras, Joseph McClanaghan, Xianghong Wang, Alan C. Cheng, Kathleen S. Keegan, Jonathan B. Houze, Leah J. Damon, Patricia Greninger, Brian Belmontes
Publikováno v:
Cancer discovery. 8(12)
The prosurvival BCL2 family member MCL1 is frequently dysregulated in cancer. To overcome the significant challenges associated with inhibition of MCL1 protein–protein interactions, we rigorously applied small-molecule conformational restriction, w
Autor:
Jerry Evarts, Gary Phillips, Joshua Kaplan, David Koditek, Kathleen S. Keegan, Adam Kashishian, Zhi-Hua Cui, Joseph Therrien, Jennifer Treiberg, Bart Phillips, Latesh Lad, Eve-Irene Lepist, Jayaraman Chandrasekhar, Leena Patel, Anella Yahiaoui, Stephane Perreault, Jia Hao, Mary E. McGrath, Thomas Kenney
Publikováno v:
Journal of medicinal chemistry. 60(4)
Phosphoinositide 3-kinase (PI3K) β signaling is required to sustain cancer cell growth in which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated. This manuscript describes the discovery, optimization, and in vivo evalu
Autor:
Kathleen S. Keegan, Hong Shu, Michael D. Bartberger, Julie M. Bailis, Guomin Yao, Jennifer Dao, Matthew R. Kaller, Andreas Reichelt, John G. Allen, Margaret F. Weidner
Publikováno v:
European Journal of Medicinal Chemistry. 80:364-382
The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in t
Publikováno v:
Cancer Research. 78:2371-2371
Spleen tyrosine kinase (SYK), a non-receptor protein tyrosine kinase, is an important mediator of immune receptor signaling in B cells, mast cells, neutrophils, and macrophages. SYK is expressed in 90% of AML blasts and has been reported to be is con
Autor:
Zhi-Hua Cui, Christophe Quéva, Li Li, Sarah A. Meadows, Anella Yahiaoui, Stacey Tannheimer, Rick Sorensen, Robert Brockett, Guang Chen, Kathleen S. Keegan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0171221 (2017)
PLoS ONE, Vol 12, Iss 2, p e0171221 (2017)
Activated B-cell-like diffuse large B-cell lymphoma relies on B-cell receptor signaling to drive proliferation and survival. Downstream of the B-cell receptor, the key signaling kinases Bruton's tyrosine kinase and phosphoinositide 3-kinase δ offer