Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel

Autor: James B. Brewer, Marilyn S. Albert, Bradley T. Hyman, Takiyah D. Starks, Russell H. Swerdlow, Jeffery M. Vance, Mary Sano, Gerard D. Schellenberg, Jennifer J. Manly, Walter A. Kukull, Jaeyoon Chung, Temitope Ayodele, Tatiana Foroud, Christiane Reitz, Thomas Wisniewski, Lindsay A. Farrer, Eric B. Larson, Laura B. Cantwell, David A. Bennett, Victor W. Henderson, Kara L. Hamilton-Nelson, Neill R. Graff-Radford, Hugh C. Hendrie, Denis A. Evans, Charles DeCarli, Scott A. Small, Joe D. Buxbaum, Paul K. Crane, M. Ilyas Kamboh, Robert Vassar, Suzanne Craft, M. Daniele Fallin, Richard Mayeux, Jonathan L. Haines, Melissa Jean-Francois, Izri Martinez, Thomas O. Obisesan, Li Sao Wang, John Q. Trojanowski, Jeffrey Kaye, Kathryn L. Lunetta, Frank M. LaFerla, Linda J. Van Eldik, Andrew J. Saykin, Bruce L. Miller, Lisa L. Barnes, Roger N. Rosenberg, John C. Morris, Michael A. Schmidt, Ronald C. Petersen, Eric M. Reiman, Kathleen S. Hall, Michael L. Cuccaro, Gyungah Jun, Goldie S. Byrd, Rodney C.P. Go, Oscar L. Lopez, Alison Goate, Margaret A. Pericak-Vance, Hans-Ulrich Klein, Jesse Mez, Brian W. Kunkle, Adam C. Naj, Thomas J. Grabowski, Eden R. Martin, Allan I. Levey, Larry D. Adams, Henry L. Paulson, James B. Leverenz, Stephen M. Strittmatter, Nilufer Ertekin-Taner, Todd E. Golde, Sanjay Asthana, Neil W. Kowall, Mark W. Logue, Amanda B. Kuzma, Helena C. Chui, Phil De Jager

Publikováno v: JAMA Neurol

Importance Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide associatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee52cefbfce96fcd1914deb7b5af8752
https://doi.org/10.1001/jamaneurol.2020.3536

Homocysteine levels and dementia risk in Yoruba and African Americans

Autor: Jill R. Murrell, Ann Marie Hake, Frederick W. Unverzagt, Kathleen A. Lane, Oye Gureje, Mark A. Deeg, Christianna Purnell, Adesola Ogunniyi, Sujuan Gao, Olusegun Baiyewu, Kathleen S. Hall, Hugh C. Hendrie

Publikováno v: International Psychogeriatrics. 25:1859-1866

Background:High levels of homocysteine have been associated with increased risk for dementia although results have been inconsistent. There are no reported studies from the developing world including Africa.Methods:In this longitudinal study of two c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd64fcaf7a71211f8eea7b3359d4d23
https://doi.org/10.1017/s1041610213001294

Genetic architecture of age-related cognitive decline in African Americans

Autor: Towfique Raj, Frederick W. Unverzagt, Lisa L. Barnes, Tatiana Foroud, Lei Yu, Jill R. Murrell, Hugh C. Hendrie, Cristin McCabe, Joseph M. Replogle, Barbara E. Stranger, Andus Hon-Kit Wong, David A. Bennett, Sujuan Gao, Denis A. Evans, Philip L. De Jager, Kathleen S. Hall, Lori B. Chibnik, Anna M. Krichevsky

Publikováno v: Neurology: Genetics

Objective:To identify genetic risk factors associated with susceptibility to age-related cognitive decline in African Americans (AAs).Methods:We performed a genome-wide association study (GWAS) and an admixture-mapping scan in 3,964 older AAs from 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e225a44bb299a96d1afae3c0722846
http://europepmc.org/articles/PMC5206965

Late Life Leisure Activities and Risk of Cognitive Decline

Autor: Lili Yang, Hugh C. Hendrie, Feng Ma, Jianchao Bian, Jin Jing Pei, Chaoke Liang, Frederick W. Unverzagt, Yinlong Jin, Sujuan Gao, Jill R. Murrell, Ping Li, Yibin Cheng, Hui-Xin Wang, Kathleen S. Hall

Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 68:205-213

Studies concerning the effect of different types of leisure activities on various cognitive domains are limited. This study tests the hypothesis that mental, physical, and social activities have a domain-specific protection against cognitive decline.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f06b96a7e9ec8e967b0d999a1136d2c
https://doi.org/10.1093/gerona/gls153

Behavioral symptoms in community-dwelling elderly Nigerians with dementia, mild cognitive impairment, and normal cognition

Autor: Fred Unverzagt, Sujuan Gao, Olusegun Baiyewu, Kathleen A. Lane, Oye Gureje, Hugh C. Hendrie, Valerie Smith-Gamble, Adesola Ogunniyi, Kathleen S. Hall

Publikováno v: International Journal of Geriatric Psychiatry. 27:931-939

Background Few studies have examined the neuropsychiatric status of patients with dementia and cognitive impairment in the developing world despite the fact that current demographic trends suggest an urgent need for such studies. Objective To assess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b67bebe3fbb0ec583cd1169ef24f48a
https://doi.org/10.1002/gps.2804