Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Kathleen Rundell"'
Autor:
Janie Bernal, Noriko Itoh, Harumi Kasamatsu, Ole Gjoerup, Akira Nakanishi, Kathleen Rundell, Marika Watanabe, Chu-Han Huang, Ellen Phamduong
Publikováno v:
Journal of Virology. 87:5053-5064
The folding and pentamer assembly of the simian virus 40 (SV40) major capsid protein Vp1, which take place in the infected cytoplasm, have been shown to progress through disulfide-bonded Vp1 folding intermediates. In this report, we further demonstra
Publikováno v:
Journal of Virological Methods. 150:7-13
Three simian virus 40 (SV40) reporter viruses were constructed in this study. One expresses the green fluorescent protein (GFP) as a fusion protein with the first exon of large-T (LT) antigen and is useful for live-cell imaging. A second reporter vir
Publikováno v:
Journal of Biological Chemistry. 280:40195-40200
The structurally related ATM (ataxia-telangiectasia-mutated) and ATR (ATM-Rad3-related) protein kinases fulfill overlapping yet non-redundant functions as key regulators of cellular DNA damage responses. We recently showed that ATM phosphorylates the
Publikováno v:
Journal of Virology. 78:4917-4920
Lymphoblastic cell lines were infected with simian virus 40 (SV40) and then monitored for evidence of a productive infection. No evidence of early gene expression was found 2 days following infection, as determined by assaying viral mRNAs and early a
Publikováno v:
Cell Cycle. 3:604-608
SV40 LT and ST antigens cooperate to induce the proliferation and eventual transformation of several human cell types. In natural virus infections, ST often enhances the function of LT when both proteins are present, and it can be difficult to comple
Autor:
James M. Pipas, Jai V. Vartikar, Pierre Genevaux, Françoise Schwager, Florence Lang, Costa Georgopoulos, Kathleen Rundell, William L. Kelley
Publikováno v:
Journal of Virology, Vol. 77, No 19 (2003) pp. 10706-10713
The N-terminal exon of DNA tumor virus T antigens represents a J domain that can direct interaction with the host-encoded Hsp70 chaperones. We have taken advantage of rapid Hsp40 cochaperone assays with Escherichia coli to assess simian virus 40 (SV4
Publikováno v:
Virology. 315:148-158
Transformation of human cells requires both SV40 large T and small t antigens. Plasmids that contained mutations in the amino-terminal dnaJ domain of the early region fail to transform human diploid fibroblasts. However, large T dnaJ mutants can be r
Publikováno v:
Journal of Virology. 76:10685-10691
Human keratinocytes immortalized by full-length or early-region simian virus 40 (SV40) DNA grow in agarose and form tumors in nude mice, in contrast to keratinocytes immortalized by the E6/E7 genes of human papillomaviruses. To determine the molecula
Publikováno v:
Virology. 290(2):192-198
Defining the ability of simian virus 40 (SV40) to transform human cells has become of even greater importance with the increased understanding that this virus may play a role in some human malignancies. This report documents the requirement for viral
Publikováno v:
Journal of Virology. 74:875-882
Deletion of the entire leader polypeptide of the GDVII strain of Theiler's murine encephalomyelitis virus (TMEV) results in the production of an attenuated virus that grows in baby hamster kidney (BHK) cells but cannot grow at all in mouse L-929 cell