Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kathleen Richter"'
Autor:
Ming-Lang Zhao, Janssen Daly, Danielle L. Watt, Marilyn Diaz, Thomas A. Kunkel, Madhumita Ray, Katarzyna Bebenek, Kathleen Richter, Chuancang Jiang, W. Glenn McGregor
Publikováno v:
The Journal of Immunology. 188:5528-5537
To test the hypothesis that DNA polymerase ζ participates in Ig hypermutation, we generated two mouse models of Pol ζ function: a B cell-specific conditional knockout and a knock-in strain with a Pol ζ mutagenesis-enhancing mutation. Pol ζ-defici
Publikováno v:
Molecular Immunology. 44:900-905
IRAK family proteins play critical roles in regulating innate immunity. There are three differentially spliced variants of IRAK1, namely 1, 1b, and 1c. We and others have previously identified that the full length IRAK1 underwent covalent modificatio
Autor:
Klaus Ruckdeschel, Kathleen Richter
Publikováno v:
Infection and Immunity. 70:5259-5264
PathogenicYersiniaspp. uncouple an array of signal transduction pathways in macrophages to disrupt their response to infection. This compels the macrophage to undergo apoptosis. Our study shows that macrophages that had acquired tolerance toYersiniai
Publikováno v:
Infection and Immunity. 69:7652-7662
Pathogenic Yersinia spp. counteract host defense mechanisms by modulating the cellular signal relay in response to infection. Subversion of the antiapoptotic NF-κB signaling pathway by the Yersinia enterocolitica virulence protein YopP crucially det
Publikováno v:
Somatic Cell and Molecular Genetics. 25:333-342
Previous work had shown a large accumulation (up to 50% of mtDNA) of a noninherited T414G transversion at a critical control site for mtDNA replication in skin fibroblasts from the majority of human subjects above 65 years old, and its absence in you
Autor:
Silvia Bolland, Laurent Verkoczy, Madhumita Ray, Marilyn Diaz, Prapaporn Pisitkun, Sukhdev S. Brar, Kathleen Richter
Publikováno v:
The Journal of biological chemistry. 284(44)
We identified a novel GTPase, SLIP-GC, with expression limited to a few tissues, in particular germinal center B cells. It lacks homology to any known proteins, indicating that it may belong to a novel family of GTPases. SLIP-GC is expressed in germi
Autor:
Ingo B. Autenrieth, Kathleen Richter, Sabine Gröbner, Olivier Micheau, Klaus Ruckdeschel, Sebastian Wesselborg, Stefan Borgmann, Irena Adkins, Sebastian Schulz
Publikováno v:
Apoptosis : an international journal on programmed cell death. 12(10)
Yersinia outer protein P (YopP) is injected by Y. enterocolitica into host cells thereby inducing apoptotic and necrosis-like cell death in dendritic cells (DC). Here we show the pathways involved in DC death caused by the catalytic activity of YopP.
Autor:
Konrad Trülzsch, Gerhardt Zenner, Kathleen Richter, Klaus Ruckdeschel, Gudrun Pfaffinger, Jürgen Heesemann, Martin Aepfelbacher
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 176(10)
Pathogenic Yersinia spp. neutralize host defense mechanisms by engaging a type III protein secretion system that translocates several Yersinia outer proteins (Yops) into the host cell. Although the modulation of the cellular responses by individual Y
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(12)
Pathogenic Yersinia spp. use a panel of virulence proteins that antagonize signal transduction processes in infected cells to undermine host defense mechanisms. One of these proteins, Yersinia enterocolitica outer protein P (YopP), down-regulates the
Autor:
Ian McCarthy, Sigurd Berven, Christopher P. Ames, Gerald Ogola, Rajiv Saigal, Neil S. Fleming, Michael O'Brien, Rustam Kudyakov, Richard A. Hostin, Kathleen Richter, Vedat Deviren
Publikováno v:
The Spine Journal. 12:S40-S41