Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kathleen R. Chirco"'
Autor:
Kelly Mulfaul, Ema Ozaki, Nilisha Fernando, Kiva Brennan, Kathleen R. Chirco, Emma Connolly, Chris Greene, Arvydas Maminishkis, Robert G. Salomon, Mikhail Linetsky, Riccardo Natoli, Robert F. Mullins, Matthew Campbell, Sarah L. Doyle
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2209-2224.e5 (2020)
Summary: Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. Here we show tha
Externí odkaz:
https://doaj.org/article/835c88f2ea654e568ca728ae96a0f4bf
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Age-related macular degeneration (AMD) is a devastating neurodegenerative disease affecting millions worldwide. Complement activation, inflammation, and the loss of choroidal endothelial cells have been established as key factors in both normal aging
Externí odkaz:
https://doaj.org/article/8a7f7f2a6f6c4b78b6a5d59c5983a1c6
Publikováno v:
Vision Research. 209:108257
Publikováno v:
Stem cell reports, vol 16, iss 11
Stem Cell Reports
Stem Cell Reports
Summary Cases of Leber congenital amaurosis caused by mutations in CRX (LCA7) exhibit an early form of the disease and show signs of significant photoreceptor dysfunction and eventual loss. To establish a translational in vitro model system to study
Autor:
Robert F. Mullins, Kathleen R. Chirco, Robert G. Salomon, Emma Connolly, Chris H. Greene, Mikhail Linetsky, Kiva Brennan, Nilisha Fernando, Ema Ozaki, Matthew Campbell, Sarah L. Doyle, Kelly Mulfaul, Arvydas Maminishkis, Riccardo Natoli
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2209-2224.e5 (2020)
Cell reports
Cell reports
SUMMARY Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. Here we show that
Publikováno v:
Investigative Opthalmology & Visual Science. 63:12
PurposeTransplanting photoreceptors from human pluripotent stem cell derived retinal organoids have the potential to reverse vision loss in affected individuals. However, transplantable photoreceptors are only a subset of all cells in the organoids.
Autor:
Xiuying Liu, Meng Wu, Robert F. Mullins, Elliott H. Sohn, Shemin Zeng, Edwin M. Stone, Grefachew Workalemahu, Kathleen R. Chirco, Miles J. Flamme-Wiese, Budd A. Tucker, Kuo-Kuang Wen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports
Scientific Reports
Age-related macular degeneration (AMD) is a common, blinding disease associated with increased complement system activity. Eyes with AMD show elevated accumulation of the membrane attack complex (MAC) in the choriocapillaris and degeneration of macul
Autor:
Luke A Wiley, Erin R Burnight, Budd A. Tucker, Kristan S. Worthington, Laura R. Bohrer, Kathleen R. Chirco, Jessica R. Thompson, Robert F. Mullins, Jessica A. Cooke, Arlene V. Drack, Joseph C. Giacalone, Edwin M. Stone, John H. Fingert
Publikováno v:
Prog Retin Eye Res
Gene correction is a valuable strategy for treating inherited retinal degenerative diseases, a major cause of irreversible blindness worldwide. Single gene defects cause the majority of these retinal dystrophies. Gene augmentation holds great promise
Publikováno v:
Advances in experimental medicine and biology. 1186
There is an increasing effort toward generating replacement cells for neuronal application due to the nonregenerative nature of these tissues. While much progress has been made toward developing methodologies to generate these cells, there have been
Autor:
Wendy Cedron-Craft, Deepak A. Lamba, Jie Zhu, Shereen Chew, Heinrich Jasper, Joana Neves, Kathleen R. Chirco
Publikováno v:
Exp Gerontol
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Copyright © 2020 Elsevier Inc. All rights reserved.
Ageing is a major risk factor for vision loss, and inflammation is an important contributor to retinal disease in the elderly. Regenerative medicine based on cell replacement strategies has em
Ageing is a major risk factor for vision loss, and inflammation is an important contributor to retinal disease in the elderly. Regenerative medicine based on cell replacement strategies has em