Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kathleen R. Braun"'
Autor:
Mary Nivison, Ingrid A. Harten, Inkyung Kang, Christina K. Chan, Thomas N. Wight, Mervyn J. Merrilees, Nadine Nagy, Sean Reyes Ibarrientos, Kiran J. Agarwal, Gail Workman, Kathleen R. Braun, Gernot Kaber, Michael G. Kinsella
Publikováno v:
Matrix Biol
Versican is a large extracellular matrix (ECM) chondroitin sulfate (CS) proteoglycan found in most soft tissues, which is encoded by the VCAN gene. At least four major isoforms (V0, V1, V2, and V3) are generated via alternative splicing. The isoforms
Autor:
Kathleen R Braun, Allison M DeWispelaere, Steven L Bressler, Nozomi Fukai, Richard D Kenagy, Lihua Chen, Alexander W Clowes, Michael G Kinsella
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43701 (2012)
Syndecans are receptors for soluble ligands, including heparin-binding growth factors, and matrix proteins. However, intracellular targets of syndecan-1 (Sdc-1)-mediated signaling are not fully understood. A yeast two-hybrid protein interaction scree
Externí odkaz:
https://doaj.org/article/d1067a71f8b64f15a4ce28c9d9b731bf
Autor:
William C. Parks, Michael G. Kinsella, Thomas N. Wight, Kathleen R. Braun, Michael Gale, Anne M. Manicone, Mary Y. Chang, Charles W. Frevert, William A. Altemeier, Tara Wigmosta, Inkyung Kang
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 313:L1069-L1086
Growing evidence suggests that versican is important in the innate immune response to lung infection. Our goal was to understand the regulation of macrophage-derived versican and the role it plays in innate immunity. We first defined the signaling ev
Autor:
Allison Arrigoni, Ying Lai, Maryam G. Rohani, Timothy P. Birkland, Pradeep K. Singh, Lia A. Michaels, Kathleen R. Braun, Paul L. Bollyky, Teal S. Hallstrand, Patrick R. Secor, William C. Parks, Kate S. Smigiel, Katherine B. Hisert, Laura K. Jennings
Publikováno v:
Infection and Immunity. 85
Pseudomonas aeruginosa is an important opportunistic human pathogen that lives in biofilm-like cell aggregates at sites of chronic infection, such as those that occur in the lungs of patients with cystic fibrosis and nonhealing ulcers. During growth
Publikováno v:
Journal of Biological Chemistry. 289:15393-15404
Monocyte/macrophage accumulation plays a critical role during progression of cardiovascular diseases, such as atherosclerosis. Our previous studies demonstrated that retrovirally mediated expression of the versican V3 splice variant (V3) by arterial
Autor:
Michael G. Kinsella, Pamela Y. Johnson, Christina K. Chan, Steven F. Ziegler, Mary Nivison, Mary Y. Chang, Gernot Kaber, Charles W. Frevert, Thomas N. Wight, Mervyn J. Merrilees, Alyssa Sheih, Gail Workman, Kathleen R. Braun, Stephen P. Evanko, Ingrid A. Harten, Inkyung Kang
Viral infection is an exacerbating factor contributing to chronic airway diseases, such as asthma, via mechanisms that are still unclear. Polyinosine-polycytidylic acid (poly(I:C)), a Toll-like receptor 3 (TLR3) agonist used as a mimetic to study vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c101a6b4e5b5e37917b597f216743f
https://europepmc.org/articles/PMC5217699/
https://europepmc.org/articles/PMC5217699/
Publikováno v:
Journal of Histochemistry and Cytochemistry
The pancreatic islet comprises endocrine, vascular, and neuronal cells. Signaling among these cell types is critical for islet function. The extracellular matrix (ECM) is a key regulator of cell-cell signals, and while some islet ECM components have
Autor:
Thomas N. Wight, Charles E. Murry, Veronica Muskheli, Kathleen R. Braun, Kareen L. Kreutziger, Pamela Y. Johnson
Publikováno v:
Tissue Engineering Part A. 17:1219-1228
We recently developed a scaffold-free patch of human myocardium with human embryonic stem cell-derived cardiomyocytes and showed that stromal and endothelial cells form vascular networks in vitro and improve cardiomyocyte engraftment. Here, we hypoth
Autor:
S. Alice Long, Paul L. Bollyky, Gregory E. Holt, Anton Preisinger, Ben A. Falk, Brandon Teng, Nathan Standifer, Cindy Fang Xie, Gerald T. Nepom, John A. Gebe, Kathleen R. Braun, Robert B. Vernon, Peter L. Samuels, Rebecca P. Wu, James D. Lord, Thomas N. Wight
Publikováno v:
Proceedings of the National Academy of Sciences. 108:7938-7943
We describe a role for ECM as a biosensor for inflammatory microenvironments that plays a critical role in peripheral immune tolerance. We show that hyaluronan (HA) promotes induction of Foxp3- IL-10–producing regulatory T cells (TR1) from conventi
Autor:
Leonard C. Altman, Thomas N. Wight, Kathleen R. Braun, Susan Potter-Perigo, Pamela Y. Johnson, Stephen P. Evanko, Christina K. Chan, Thomas S. Wilkinson
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 43:109-120
Viral infections are known to exacerbate asthma and other lung diseases in which chronic inflammatory processes are implicated, but the mechanism is not well understood. The viral mimetic, polyinosine-polycytidylic acid, causes accumulation of a vers