Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kathleen R Nicholson"'
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010610 (2022)
Externí odkaz:
https://doaj.org/article/598ab8a4b14a4bfcb58390f58970140b
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009124 (2021)
Mycobacterial pathogens pose a sustained threat to human health. There is a critical need for new diagnostics, therapeutics, and vaccines targeting both tuberculous and nontuberculous mycobacterial species. Understanding the basic mechanisms used by
Externí odkaz:
https://doaj.org/article/cb022204bac0483da6f50be590b30e82
Autor:
Bradley S. Jones, Daniel D. Hu, Kathleen R. Nicholson, Rachel M. Cronin, Simon D. Weaver, Matthew M. Champion, Patricia A. Champion
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors. ESX-1 (ESAT-6 syste
Externí odkaz:
https://doaj.org/article/63c1e0bddc6843a287d8a6f4cb68bdb7
Autor:
Kathleen R. Nicholson, Rachel M. Cronin, Rebecca J. Prest, Aruna R. Menon, Yuwei Yang, Madeleine K. Jennisch, Matthew M. Champion, David M. Tobin, Patricia A. Champion
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTBacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum, the ESAT-6 system 1 (ESX-1) secretio
Externí odkaz:
https://doaj.org/article/98c5e246555a43a18ff67290f38d2e86
Autor:
Kathleen R. Nicholson, Rachel M. Cronin, Aruna R. Menon, Madeleine K. Jennisch, David M. Tobin, Patricia A. Champion
Publikováno v:
bioRxiv
Bacterial pathogens use protein secretion systems to translocate virulence factors into the host and to control bacterial gene expression. The ESX-1 (ESAT-6 system 1) secretion system facilitates disruption of the macrophage phagosome during infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be6350a29983cb99cce050ce4e1bc5
https://doi.org/10.1101/2023.02.15.528779
https://doi.org/10.1101/2023.02.15.528779
Autor:
Kevin G. Sanchez, Rebecca J. Prest, Kathleen R. Nicholson, Konstantin V. Korotkov, Patricia A. Champion
Publikováno v:
J Bacteriol
Pathogenic mycobacteria use the ESX-1 secretion system to escape the macrophage phagosome and survive infection. We demonstrated that the ESX-1 system is regulated by feedback control in Mycobacterium marinum, a nontuberculous pathogen and model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97eb16559dd90b2d3cb7dd8abaeb7f68
https://europepmc.org/articles/PMC9765225/
https://europepmc.org/articles/PMC9765225/
Autor:
Matthew M. Champion, Patricia A. DiGiuseppe Champion, Kathleen R. Nicholson, C. Bruce Mousseau
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009124 (2021)
PLoS Pathogens
PLoS Pathogens
Mycobacterial pathogens pose a sustained threat to human health. There is a critical need for new diagnostics, therapeutics, and vaccines targeting both tuberculous and nontuberculous mycobacterial species. Understanding the basic mechanisms used by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb46dcef70b78f2b72577c3f86315f32
https://doaj.org/article/cb022204bac0483da6f50be590b30e82
https://doaj.org/article/cb022204bac0483da6f50be590b30e82
Autor:
Alexandra E. Chirakos, Allison Huffman, Kathleen R. Nicholson, Patricia A. DiGiuseppe Champion
Publikováno v:
Infect Immun
Mycobacterium tuberculosis, the cause of human tuberculosis, and Mycobacterium marinum, a nontubercular pathogen with a broad host range, require the ESX-1 secretion system for virulence. The ESX-1 system secretes proteins which cause phagosomal lysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd8018a9543fd31ed28c141fa56574f
https://doi.org/10.1128/iai.00289-20
https://doi.org/10.1128/iai.00289-20
Autor:
Kathleen R. Nicholson, Robert B. Abramovitch, Patricia A. DiGiuseppe Champion, Micah J. Ferrell, Kevin G. Sanchez, Matthew M. Champion, Alexandra E. Chirakos
Publikováno v:
mBio
mBio, Vol 11, Iss 1, p e02807-19 (2020)
mBio, Vol 11, Iss 1 (2020)
mBio, Vol 11, Iss 1, p e02807-19 (2020)
mBio, Vol 11, Iss 1 (2020)
Mycobacterial pathogens use the ESX-1 system to transport protein substrates that mediate essential interactions with the host during infection. We previously demonstrated that in addition to transporting proteins, the ESX-1 secretion system regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d067895232a9c7a52eaad1e954abe9a8
https://pubmed.ncbi.nlm.nih.gov/32019792
https://pubmed.ncbi.nlm.nih.gov/32019792
Publikováno v:
mSphere, Vol 5, Iss 1, p e00744-19 (2020)
mSphere, Vol 5, Iss 1 (2020)
mSphere
mSphere, Vol 5, Iss 1 (2020)
mSphere
Trypanosoma brucei causes human African trypanosomiasis and a wasting disease called Nagana in livestock. Current treatments are expensive, toxic, and difficult to administer. Because of this, the search for new drug targets is essential. T. brucei h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d06f9a6eb2e4bffef230871f16cac1
https://doaj.org/article/060f3887318747699c1c3c70915c08e2
https://doaj.org/article/060f3887318747699c1c3c70915c08e2