Výsledky vyhledávání - "Kathleen R, Lottenbach"

A phase I safety and immunogenicity dose escalation trial of plague vaccine, Flagellin/F1/V, in healthy adult volunteers (DMID 08-0066)

Autor: Kanwaldeep Bajwa, Steven B. Mizel, Ryan C. May, Sharon E. Frey, Kathleen R. Lottenbach, Irene Graham, Robert B. Belshe, Aaron H. Graff, Edwin L. Anderson

Publikováno v: Vaccine. 35:6759-6765

Introduction Intentional aerosolization of Yersinia pestis may result in pneumonic plague which is highly fatal if not treated early. Methods We conducted a phase 1 randomized, double blind (within each group), placebo controlled, dose escalation tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a611db6ae7cc6301e26cc7dc98f188
https://doi.org/10.1016/j.vaccine.2017.09.070

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Comparisons of the Humoral and Cellular Immune Responses Induced by Live Attenuated Influenza Vaccine and Inactivated Influenza Vaccine in Adults

Autor: Thomas P. Pacatte, Azra Blazevic, Aldin Turan, Robert B. Belshe, Stella G. Hoft, Daniel F. Hoft, Michelle C. Mitchell, Kathleen R. Lottenbach, Tamara P. Blevins, Yinyi Yu

Publikováno v: Clinical and Vaccine Immunology. 24

Both live attenuated influenza vaccines (LAIV) and inactivated influenza vaccines (IIV) induce protective immunity against influenza. There is evidence that LAIV induces superior protection in children, whereas IIV may induce superior protection in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f45a0f2178534215aa36c18fc1c0d76
https://doi.org/10.1128/cvi.00414-16

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Analysis of Reversions in the 5′‐Untranslated Region of Attenuated Poliovirus after Sequential Administration of Inactivated and Oral Poliovirus Vaccines

Autor: Margaret B. Rennels, Konstantin Chumakov, Kathleen R. Lottenbach, Robert B. Belshe, Stanley A. Plotkin, Majid Laassri

Publikováno v: The Journal of Infectious Diseases. 193:1344-1349

Replication of Sabin strains used in oral poliovirus vaccine (OPV) in the intestines of vaccine recipients leads to reversions that increase virus neurovirulence. Previously, a small study reported that prior immunization with inactivated poliovirus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::470d9865bf35acc9e3faea517aa21712
https://doi.org/10.1086/503366

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Safety and Immunogenicity of Haemophilus Influenzae Type B Polysaccharide or Conjugate Vaccines in an Elderly Adult Population

Autor: Sharon Irby-Moore, Kathleen R. Lottenbach, Donald J. Kennedy, Douglas C. Powers, Dan M. Granoff, Sharon M. Homan, Stephen J. Barenkamp, ChrisAnna M. Mink

Publikováno v: Journal of the American Geriatrics Society. 52:1883-1887

Objectives: To evaluate the safety and immunogenicity of unconjugated Haemophilus influenzae type b (Hib) polysaccharide (PRP) vaccine and two PRP-protein-conjugated vaccines as a model for the comparison of protein-conjugated versus plain polysaccha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::821e11dbc7f2097f9c8e00d19adcf052
https://doi.org/10.1111/j.1532-5415.2004.52511.x

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Somatic Hypermutation and Diverse Immunoglobulin Gene Usage in the Human Antibody Response to the Capsular Polysaccharide of S treptococcus pneumoniae Type 6B

Autor: Stephen J. Barenkamp, Jianhui Zhou, Donald C. Reason, Kathleen R. Lottenbach

Publikováno v: Infection and Immunity. 72:3505-3514

Combinatorial cloning and expression library analysis were used to determine the expressed human antibody repertoire specific for the capsular polysaccharide (PS) of Streptococcus pneumoniae serotype 6B. Sequence analysis of 55 6B-specific antibody F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9aedfcd69f3f8ac593ed0dc9dffcbe
https://doi.org/10.1128/iai.72.6.3505-3514.2004

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Recurrent Variable Region Gene Usage and Somatic Mutation in the Human Antibody Response to the Capsular Polysaccharide ofStreptococcus pneumoniaeType 23F

Autor: Donald C. Reason, Kathleen R. Lottenbach, Jianhui Zhou, Alexander H. Lucas, Stephen J. Barenkamp

Publikováno v: Infection and Immunity. 70:4083-4091

Combinatorial cloning and expression library analysis were used to isolate human antibody Fab fragments specific for the capsular polysaccharide ofStreptococcus pneumoniaeserotype 23F. Thirty 23F-specific Fabs were isolated from seven vaccinated dono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960928deb3ea36571ee293d5d680ec56
https://doi.org/10.1128/iai.70.8.4083-4091.2002

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Age-Associated Differences in Immunoglobulin G1 (IgG1) and IgG2 Subclass Antibodies to Pneumococcal Polysaccharides following Vaccination

Autor: Stephen J. Barenkamp, Douglas C. Powers, Kathleen R. Lottenbach, Edwin L. Anderson, Sharon M. Homan, ChrisAnna M. Mink

Publikováno v: Infection and Immunity. 67:4935-4938

Immunoglobulin G (IgG) subclass antibody responses to pneumococcal vaccines were determined for human subjects in four age groups. The ratios of IgG1/IgG2 antibody concentrations declined with advancing age for all five of the serotypes tested. Prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd0940cb8e04942bb1d02b21fbd2984
https://doi.org/10.1128/iai.67.9.4935-4938.1999

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Rapid, sensitive recovery of recombinant attenuated Salmonella enterica serovar Typhi vaccine strains from human blood

Autor: Sandra M. Kelly-Aehle, Karen E. Brenneman, Kathleen R. Lottenbach, Sharon E. Frey, rd Roy Curtiss

Publikováno v: Clinical and vaccine immunology : CVI. 20(9)

Prior to initiating a phase 1 dose escalation trial of the safety and immunogenicity of live, oral, recombinant, attenuated Salmonella enterica serovar Typhi vaccine strains in human subjects, the suitability of conventional blood culture procedures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef186af0e7fb0b291dbab6bbce1efc1
https://pubmed.ncbi.nlm.nih.gov/23885029

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Reactogenicity and Immunogenicity of a Protein-Conjugated Pneumococcal Oligosaccharide Vaccine in Older Adults

Autor: Douglas C. Powers, Edwin L. Anderson, ChrisAnna M. Mink, Kathleen R. Lottenbach

Publikováno v: Journal of Infectious Diseases. 173:1014-1018

Healthy adults > or = 50 years old were immunized with either pentavalent Corynebacterium diphtheriae C7 (beta197) cross-reactive material (CRM197) protein-conjugated pneumococcal vaccine (CV) containing 10 microgram each of capsular oligosaccharides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bf9aa142555baed36acb615d00c0da
https://doi.org/10.1093/infdis/173.4.1014

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Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children

Autor: Getahun Abate, Isaac G. Sakala, Steven M. Truscott, Kathryn M. Edwards, Edwin L. Anderson, Robert B. Belshe, Irene Graham, Shewangizaw Worku, Charles T. Spencer, David I. Bernstein, Daniel F. Hoft, Frances K. Newman, Michael A. Gerber, Elizabeth Babusis, C. Buddy Creech, Kathleen R. Lottenbach

Publikováno v: The Journal of infectious diseases. 204(6)

Background. Two doses of either trivalent live attenuated or inactivated influenza vaccines (LAIV and TIV, respectively) are approved for young children ($24 months old for LAIV and $6 months old for TIV) and induce protective antibody responses. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de808a51b44f98905ecc0f2313f14daf
https://pubmed.ncbi.nlm.nih.gov/21846636

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