Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kathleen Petri Seiler"'
Autor:
Sigrun M Gustafsdottir, Vebjorn Ljosa, Katherine L Sokolnicki, J Anthony Wilson, Deepika Walpita, Melissa M Kemp, Kathleen Petri Seiler, Hyman A Carrel, Todd R Golub, Stuart L Schreiber, Paul A Clemons, Anne E Carpenter, Alykhan F Shamji
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80999 (2013)
Computational methods for image-based profiling are under active development, but their success hinges on assays that can capture a wide range of phenotypes. We have developed a multiplex cytological profiling assay that "paints the cell" with as man
Externí odkaz:
https://doaj.org/article/8c40507e5fdb43ab9bb993e3733562bc
Autor:
Kathleen Petri Seiler, Jane Huggins
Publikováno v:
Advances in Physiology Education. 42:393-395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d27dd82af78fd94d9532a5b0046a3d8
https://doi.org/10.1152/advan.00180.2017
https://doi.org/10.1152/advan.00180.2017
Autor:
Stefan Kubicek, Alykhan F. Shamji, Vlado Dančík, Kimberly A. Hartwell, Hyman A. Carrel, Kathleen Petri Seiler, Dina Fomina-Yadlin, Nicole E. Bodycombe, Bridget K. Wagner, Paul A. Clemons
High-throughput screening allows rapid identification of new candidate compounds for biological probe or drug development. Here, we describe a principled method to generate "assay performance profiles" for individual compounds that can serve as a bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d31dea5637fd31e1d4f5df60e2ee5e
https://europepmc.org/articles/PMC5554958/
https://europepmc.org/articles/PMC5554958/
Publikováno v:
Journal of the American Chemical Society
We show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf64b0365c39199fa0d0e2839d5b97ba
https://doi.org/10.1021/ja102798t
https://doi.org/10.1021/ja102798t
Autor:
Kathleen Petri Seiler, Deepika Walpita, Anne E. Carpenter, Hyman A. Carrel, Vebjorn Ljosa, Paul A. Clemons, Melissa M. Kemp, J. Anthony Wilson, Stuart L. Schreiber, Katherine L. Sokolnicki, Sigrun M. Gustafsdottir, Todd R. Golub, Alykhan F. Shamji
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e80999 (2013)
PLoS ONE, Vol 8, Iss 12, p e80999 (2013)
Computational methods for image-based profiling are under active development, but their success hinges on assays that can capture a wide range of phenotypes. We have developed a multiplex cytological profiling assay that “paints the cell” with as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db434b61724a0ae6ac397536563b3df9
https://pubmed.ncbi.nlm.nih.gov/24312513
https://pubmed.ncbi.nlm.nih.gov/24312513
Autor:
Ted Hawkins, Kathleen Petri Seiler, Andrew Lemon, Paul A. Clemons, Nicole E. Bodycombe, Robert Shell, Andrea de Souza
Publikováno v:
Combinatorial chemistryhigh throughput screening. 14(9)
The availability of high-throughput techniques combined with more exploratory and confirmatory studies in small-molecule science (e.g., probe- and drug-discovery) creates a significant need for structured approaches to data management. The probe- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73343487a28606781558f0928f233438
https://pubmed.ncbi.nlm.nih.gov/21631416
https://pubmed.ncbi.nlm.nih.gov/21631416
Publikováno v:
Current Protocols in Bioinformatics
ChemBank (http://chembank.broad.harvard.edu/) is a public, Web-based informatics environment. ChemBank stores and makes freely available data derived from small molecules and small-molecule screens and has resources for relating and studying these da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc648014bcd1a4edfcdf791d940ca5b2
https://pubmed.ncbi.nlm.nih.gov/18551413
https://pubmed.ncbi.nlm.nih.gov/18551413
Autor:
Paul Ferraiolo, Martin Serrano, Kathleen Petri Seiler, Paul A. Clemons, Jeremy L. Muhlich, Mary Pat Happ, Stephanie Norton, Gregory George, John P Sullivan, Nicole E. Bodycombe, Stuart L. Schreiber, Hyman A. Carrinski, Steve Brudz, Nicola Tolliday
Publikováno v:
Nucleic Acids Research
ChemBank (http://chembank.broad.harvard.edu/) is a public, web-based informatics environment developed through a collaboration between the Chemical Biology Program and Platform at the Broad Institute of Harvard and MIT. This knowledge environment inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab1fbb5f00fe187c90b18fa9b6a0f36
https://pubmed.ncbi.nlm.nih.gov/17947324
https://pubmed.ncbi.nlm.nih.gov/17947324
Autor:
Paul S. Frenette, Richard O. Hynes, Ying Ma, Janis J. Weis, John H. Weis, Kathleen Petri Seiler, Denisa D. Wagner
Publikováno v:
Infection and immunity. 66(9)
Borrelia burgdorferi -induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6576526e4ef98a0ea8dbaceb867ea21d
https://pubmed.ncbi.nlm.nih.gov/9712820
https://pubmed.ncbi.nlm.nih.gov/9712820
Autor:
Janis J. Weis, Kathleen Petri Seiler, John H. Weis, Cory Teuscher, Ernst J. Eichwald, Ying Ma
Studies of mice infected with Borrelia burgdorferi have indicated that the severity of arthritis is influenced by the genetic composition of the host: the C3H mouse develops severe arthritis while BALB/c and C57BL/6 mice develop mild arthritis. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cefd6f78f385ccee2a06cf7f0ce7a4
https://europepmc.org/articles/PMC107872/
https://europepmc.org/articles/PMC107872/