Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kathleen Ottina"'
Autor:
Brian C. Grabiner, Matthew Meyerson, Walter W. Chen, Kathleen Ottina, Scott L. Carter, David M. Sabatini, Eric D. Spear, Lynne Chantranupong, Liron Bar-Peled, Andrew D. Cherniack
Publikováno v:
Science. 340:1100-1106
Limiting mTORC1 The mTORC1 protein kinase complex has important functions linking metabolism to cell growth and its functions are disrupted in common diseases, including cancer and diabetes. Bar-Peled et al. (p. 1100 ; see the Perspective by Shaw ) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f67f47d04c43db9b8f694a8a29d63c
https://doi.org/10.1126/science.1232044
https://doi.org/10.1126/science.1232044
Autor:
Christopher L. Cervantes, Michael B. Yaffe, Hua Jane Lou, Daniel Lim, Benjamin E. Turk, Kathleen Ottina, Nathanael S. Gray, David M. Sabatini, Michael E. Pacold, Seong A. Kang
Publikováno v:
PMC
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein kinase promotes growth and is the target of rapamycin, a clinically useful drug that also prolongs life span in model organisms. A persistent mystery is why the phosphorylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d98986aadbd2d6289e20dd4a40214c5
https://doi.org/10.1126/science.1236566
https://doi.org/10.1126/science.1236566
Autor:
Jarrod A. Marto, Seong A. Kang, Kathleen Ottina, Michael B. Yaffe, Peggy P. Hsu, Yongmun Choi, Timothy R. Peterson, Yi Zhang, Daniel Lim, Nathanael S. Gray, David M. Sabatini, Jonathan Rameseder
Publikováno v:
PubMed Central
September 21 Author Manuscript
The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We de
The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce38b598e53e45bf6bff40af31978d90
https://pubmed.ncbi.nlm.nih.gov/21659593
https://pubmed.ncbi.nlm.nih.gov/21659593
Autor:
Michael E. Pacold, Shalini Sethumadhavan, Bingbing Yuan, Yoav D. Shaul, Elena F. Brachtel, Jordi Barretina, Mari Mino-Kenudson, Richard Possemato, David M. Sabatini, Hin-Koon Woo, Kıvanç Birsoy, Nicolas Stransky, Albert M. Chan, Dohoon Kim, Nada Y. Kalaany, Zhi-Yang Tsun, Levi A. Garraway, Glenn S. Cowley, David E. Root, Abhishek K. Jha, Francesca G. Barrett, Edward M. Driggers, Kevin Marks, Hyun Gyung Jang, Walter W. Chen, Kathleen Ottina, Peggy P. Hsu
Publikováno v:
PMC
Nature
Nature
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325e58be87b529818a2ad373298e4264
http://hdl.handle.net/1721.1/74552
http://hdl.handle.net/1721.1/74552
Publikováno v:
Annals of the New York Academy of Sciences. 341:465-472
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bf4c38949a7db269852fff4453b6317
https://doi.org/10.1111/j.1749-6632.1980.tb47191.x
https://doi.org/10.1111/j.1749-6632.1980.tb47191.x
Publikováno v:
Membrane Biochemistry. 5:269-290
Different conditions were studied for optimal solubilization and reconstitution of the melibiose carrier of Escherichia coli. Several alpha- and beta-galactosides, known to be substrates for the melibiose carrier, were found to inhibit [3H]-melibiose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528a7f61df428ffbb0beb6da06736483
https://doi.org/10.3109/09687688509150282
https://doi.org/10.3109/09687688509150282
Publikováno v:
The Journal of Membrane Biology. 56:169-175
p-Nitrophenyl-alpha-galactoside (alpha-pNPG) was found to be a substrate for the melibiose transport system of Escherichia coli. This sugar enters induced cells via the carrier and is split by alpha-galactosidase to galactose and p-nitrophenol. In mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4917cba4c240ace54007e38088985a2e
https://doi.org/10.1007/bf01875968
https://doi.org/10.1007/bf01875968
Autor:
Paul C. Watkins, Ernesto Bonilla, Alan Y. Sakaguchi, Nancy S. Wexler, Margaret R. Wallace, Joseph B. Martin, Kathleen Ottina, S. L. Naylor, P. Michael Conneally, Ira Shoulson, Rudolph E. Tanzi, James F. Gusella, Anne B. Young, Mary Anne Anderson
Publikováno v:
Nature. 306(5940)
Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2159d72db72f42989c298f30fd14065
https://pubmed.ncbi.nlm.nih.gov/6316146
https://pubmed.ncbi.nlm.nih.gov/6316146
Publikováno v:
Membranes and Transport ISBN: 9781468440874
Membranes and Transport
Membranes and Transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaba883750d18177fff1705038ead432
https://doi.org/10.1007/978-1-4684-4085-0_6
https://doi.org/10.1007/978-1-4684-4085-0_6