Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kathleen O'Loughlin"'
Publikováno v:
Cogent Medicine, Vol 4, Iss 1 (2017)
Introduction: Ultrasound plays an integral role in pregnancy management in Australia. The role of a sonographer as the frontline practitioner is to scan the patient and identify any possible abnormalities, including foetal demise. This study sought t
Externí odkaz:
https://doaj.org/article/24ab235a5e2b41c59ef25aa70df2b2d3
Autor:
Wanda Vélez-Carrasco, Carol E Green, Paul Catz, Anna Furimsky, Kathleen O'Loughlin, Vesna A Eterović, P A Ferchmin
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121540 (2015)
4R-cembranoid (4R) is a natural cyclic diterpenoid found in tobacco leaves that displays neuroprotective activity. 4R protects against NMDA, paraoxon (POX), and diisopropylfluorophosphate (DFP) damage in rat hippocampal slices and against DFP in rats
Externí odkaz:
https://doaj.org/article/22e3bb41ddcd49ee8ceea09b9cbfc5f1
Autor:
Kathleen O’Loughlin, Yizhe Chen, Lei Yang, Fangyi Zhu, Jared T. Hammill, Karen L. White, Gloria Holbrook, David M. Shackleford, Susan A. Charman, Jon C. Mirsalis, R. Kiplin Guy, Burgess B. Freeman
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-15 (2021)
Malaria Journal
Malaria Journal
Background The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing chemotherapies. One critical step in drug development is selecting a suitable clinical ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9272764eac4761c57cf5d92db22299b
https://doaj.org/article/ab8cf99d57bd45dc8262fb7f25bbd884
https://doaj.org/article/ab8cf99d57bd45dc8262fb7f25bbd884
Autor:
Huanying Zhou, Gene G. Olinger, Kathleen O’Loughlin, Joshua C. Johnson, Richard S. Bennett, Julia Michelotti, Anna N. Honko, Carol E. Green, Lisa E. Hensley, Yu Cong, Dawn M. Gerhardt, Steven E. Kern, Brit J. Hart, Lisa Evans DeWald, Jon C. Mirsalis, Peter B. Jahrling, Elena Postnikova, Julie Dyall
Publikováno v:
The Journal of Infectious Diseases. 218:S592-S596
At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ee92f5b100e0badb2a7fdbd09cdbbb
https://doi.org/10.1093/infdis/jiy345
https://doi.org/10.1093/infdis/jiy345
Autor:
Alexander V. Kurkin, Young Do Kwon, Dmitry S. Belov, Patricia C. Byrge, Asim K. Debnath, Anna M. Furimsky, Ranjith R. Ramesh, Andrea Altieri, Lalitha V. Iyer, Francesca Curreli, Jon C. Mirsalis, Kathleen O’Loughlin
Publikováno v:
European Journal of Medicinal Chemistry. 154:367-391
We are continuing our concerted effort to optimize our first lead entry antagonist, NBD-11021, which targets the Phe43 cavity of the HIV-1 envelope glycoprotein gp120, to improve antiviral potency and ADMET properties. In this report, we present a st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611d99713a69636ddb353a6e82f6f3a6
https://doi.org/10.1016/j.ejmech.2018.04.062
https://doi.org/10.1016/j.ejmech.2018.04.062
Publikováno v:
Sonography. 3:125-133
Introduction Advances in ultrasound technology along with increased knowledge and expectations of pregnant patients have substantially changed the sonographer role. Sonographers are now the frontline practitioners as patients expect to know the resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d052677441f2df9048d5745b6d623ca4
https://doi.org/10.1002/sono.12081
https://doi.org/10.1002/sono.12081
Autor:
Claire McFarlane, Jon C. Mirsalis, Sean Ekins, Alexander N. Freiberg, Anush Harutyunyan, Jason E. Comer, Kathleen O’Loughlin, Carol E. Green, Peter B. Madrid, Mary A. Lingerfelt
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outside the United States. A machine-learning model trained on anti-Ebola virus (EBOV) screening data previously identified tilo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269a9c0fa5bbe5aa033c8166cbf40f10
https://doi.org/10.1128/aac.01711-17
https://doi.org/10.1128/aac.01711-17
Autor:
Ruin Moaddel, Mitesh Sanghvi, Marc C. Torjman, Irving W. Wainer, Kathleen O’Loughlin, Michel Bernier, Carol E. Green, Mohammed Khadeer, Nagendra Singh, Rajib K. Paul
Publikováno v:
Anesthesiology. 121:149-159
Background: Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function of mammalian target of rapamy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0847fb51d9fd344729cd6209e6cd78f
https://doi.org/10.1097/aln.0000000000000285
https://doi.org/10.1097/aln.0000000000000285
Autor:
Milton H. Werner, Carol E. Green, Kathleen O’Loughlin, Terence A. Kelly, Gita N. Shankar, Shravan K Mutyam, Li Wang, Srinivasa M. Sammeta
Publikováno v:
Pharmaceutical Development and Technology. 20:169-175
The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097be2ddb713a162f9283126beeabab1
https://doi.org/10.3109/10837450.2013.852574
https://doi.org/10.3109/10837450.2013.852574
Autor:
Mitesh Sanghvi, Nagendra Singh, Anuradha Ramamoorthy, Irving W. Wainer, Kathleen O’Loughlin, Marc C. Torjman, Ruin Moaddel, Krzysztof Jozwiak, Carol E. Green
Subchronic administration of (R,S)-ketamine, (R,S)-Ket, is used in the treatment of neuropathic pain, in particular Complex Regional Pain Syndrome, but the effect of this protocol on the metabolism of (R,S)-Ket is unknown. In this study, daily admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd779b45b18be1a73bf811c9f2b5b8a0
https://europepmc.org/articles/PMC5972519/
https://europepmc.org/articles/PMC5972519/
