Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kathleen M. Ogilvie"'
Autor:
Robert Lester, Allison Luo, MiRa Huyghe, Kathleen M. Ogilvie, John M. Nuss, Raju Mohan, Robert Schwab, William J. Sandborn
Publikováno v:
Gastroenterology. 158:S-1188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8de976f8502362d319b3efa14a5555c
https://doi.org/10.1016/s0016-5085(20)33639-8
https://doi.org/10.1016/s0016-5085(20)33639-8
Autor:
Markus Weber, Romesh R. Subramanian, Bing Kuang, Thomas Dino Rockel, Arthur M. Krieg, Mark Allen Wysk, Kathleen M. Ogilvie, Abhijit Bhat, Eugen Uhlmann
Publikováno v:
Nucleic Acids Research
The in vivo potency of antisense oligonucleotides (ASO) has been significantly increased by reducing their length to 8–15 nucleotides and by the incorporation of high affinity RNA binders such as 2′, 4′-bridged nucleic acids (also known as lock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb7df709be6539a0b5607608f5bf4d3
https://doi.org/10.1093/nar/gkv992
https://doi.org/10.1093/nar/gkv992
Autor:
Patricia Finn, Jeff Zhang, Patrick Kearney, Raju Mohan, Tao Wang, Peter Lamb, Vicky Chan, Danny Tam, Christopher J. Larson, Kwang-Ai Won, Adam A. Galan, Amanda Harrison, Jason August Nachtigall, Art Hanel, Jon Rosen, Richards Steven J, John M. Nuss, Naing Aay, Fawn Qian, Kevin Noson, Kathleen M. Ogilvie, Hongwang Du, Elena S. Koltun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6773-6777
A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68aa3f4462e296a5ca699bcb45dea236
https://doi.org/10.1016/j.bmcl.2011.09.037
https://doi.org/10.1016/j.bmcl.2011.09.037
Autor:
Karen Siegel, Helen Kim Cho, David Looper, Shawn C Black, Xiao-Hong Yu, Scott Rp McDonnell, Dawn Kelly-Sullivan, Sergei Timofeevski, Junming Yie, Celia P. Briscoe, Kathleen M. Ogilvie, Ping Chen, Manli Shi, James S. Fraser
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E1142-E1151
c-Jun NH2-terminal kinase (JNK) plays an important role in insulin resistance; however, identification of pharmacologically potent and selective small molecule JNK inhibitors has been limited. Compound A has a cell IC50 of 102 nM and is at least 100-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cb6cb9c6eb48edf3850c4ed514bdf5
https://doi.org/10.1152/ajpendo.90298.2008
https://doi.org/10.1152/ajpendo.90298.2008
Autor:
Kimbie Palacio, B. Ganesh Bhat, George Hur, Bart Jessen, Jocelyn Herrera, Husam S. Younis, Kathleen M. Ogilvie, Bernadette Pascual, Paul A. Rejto
Publikováno v:
Biochemical and Biophysical Research Communications. 365:740-745
The inhibition of 11betahydroxysteroid dehydrogenase 1 (11betaHSD1), an enzyme that catalyzes the conversion of inactive cortisone to active cortisol, is an attractive target to treat diabetes by suppressing hepatic gluconeogenesis. To test this hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995224981a27bd87062f54cdfddc7a9c
https://doi.org/10.1016/j.bbrc.2007.11.032
https://doi.org/10.1016/j.bbrc.2007.11.032
Publikováno v:
dressNature Reviews Drug Discovery
dressNature Reviews Drug Discovery, 2007, 6 (10), pp.793-810. ⟨10.1038/nrd2397⟩
dressNature Reviews Drug Discovery, 2007, 6 (10), pp.793-810. ⟨10.1038/nrd2397⟩
Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. The success of RAR modulation in the treatment of acute promyelocytic leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8d85c9025057ceeaf89aa718817d5a
https://doi.org/10.1038/nrd2397
https://doi.org/10.1038/nrd2397
Autor:
Kathleen M. Ogilvie, James D. Fraser, Quyen-Quyen T. Do, Thomas J. Carlson, Mary Hess, Paul S. Humphries, Jonathon V. Almaden, Young Ha Kim, Sandra J. Barnum, Shaoxian Sun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6116-6119
A series of novel pyridine-2-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARalpha/gamma agonists with varied isoform selectivity. Based on the results of effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efd756b494a258f44b506df95874ccb
https://doi.org/10.1016/j.bmcl.2006.08.105
https://doi.org/10.1016/j.bmcl.2006.08.105
Autor:
James R. Paterniti, James M. Bilakovics, Mccarthy James R, William R. Bensch, Joseph T. Brozinick, Brian A. Oldham, Garret J. Etgen, Kathleen M. Ogilvie, Sha Liu, Christopher John Rito, Carol L. Broderick, Anthony J. Shuker, Robert J. Ardecky, James S. Bean, Elizabeth A. Misener, John S. Tyhonas, Sharon L. Dana, William T. Johnson, Dawn A. Brooks, Raymond F. Kauffman, Chahrzad R. Montrose
Publikováno v:
Diabetes. 51:1083-1087
A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-α/γ agonist, LY465608, was designed to address the major metabolic disturbances of type 2 diabetes. LY465608 altered PPAR-responsive genes in liver and fat of db/d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b450b25eeadc156ea632676a20dd572
https://doi.org/10.2337/diabetes.51.4.1083
https://doi.org/10.2337/diabetes.51.4.1083
Publikováno v:
Biology of Reproduction. 60:527-533
Exposure to disease or injury often results in impaired reproductive activity accompanied by decreased testosterone levels. After immune activation, the cytokine interleukin 1-β (IL-1β) circulates in high concentrations, and its exogenous administr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::769e7bdceb87110a89097dee034a2993
https://doi.org/10.1095/biolreprod60.2.527
https://doi.org/10.1095/biolreprod60.2.527