Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kathleen M. Mulvaney"'
Autor:
Jon Sampedro, Steven J. Smith, Iñaki Arto, Mikel González-Eguino, Anil Markandya, Kathleen M. Mulvaney, Cristina Pizarro-Irizar, Rita Van Dingenen
Publikováno v:
Environment International, Vol 136, Iss , Pp - (2020)
This study assesses the reductions in air pollution emissions and subsequent beneficial health effects from different global mitigation pathways consistent with the 2 °C stabilization objective of the Paris Agreement. We use an integrated modelling
Externí odkaz:
https://doaj.org/article/245dc0cb77644b77ba258dd723cbd5c2
Autor:
Dale Porter, Alessandra Ianari, Merissa Brousseau, Patrick McCarren, Foxy P. Robinson, Adam Skepner, Virendar K. Kaushik, Kathleen M. Mulvaney, Arthur J. Campbell, Martin J Drysdale, Zachary Mullin-Bernstein, Brian J. McMillan, Robert Hilgraf, Ritu Singh, Matthew J. Ranaghan, Meghan O’Keefe, William R. Sellers, David C. McKinney, Jamie A. Moroco, Michael F. Mesleh, David E. Timm, Besnik Bajrami, Florence F. Wagner
Publikováno v:
J Med Chem
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to a surface of PRMT5 distal to the catalytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2c09646bd9e9db576eb95fa59b4da5
https://doi.org/10.1021/acs.jmedchem.1c00507
https://doi.org/10.1021/acs.jmedchem.1c00507
Autor:
Yanfang Zheng, Darmood Wei, D. Neil Hayes, Kathleen M. Mulvaney, Shujie Song, Travis P. Schrank, Vinh Nguyen, Michael B. Major, Nisarg Desai, Tess Orvis, Vonn Walter, Jiren Zhang, Bernard E. Weissman
Publikováno v:
Mol Cancer Res
The NF-E2–related factor 2 (referred to as NRF2) transcription factor binds antioxidant responsive elements within the promoters of cytoprotective genes to induce their expression. Next-generation sequencing studies in lung cancer have shown a sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0df188eca2ce374b7d7f1e4afe6846e
https://doi.org/10.1158/1541-7786.mcr-20-0082
https://doi.org/10.1158/1541-7786.mcr-20-0082
Autor:
Andrew J. Aguirre, Nischal Acharya, Adam Skepner, Christa Blomquist, David C. McKinney, Michael J. Young, Meghan O’Keefe, Ruitong Li, Debjani Pal, Kathleen M. Mulvaney, Yelena Freyzon, Matthew E. Stokes, Fazli K. Bozal, Donald Raymond, Matthew J. Ranaghan, Devishi Kesar, Diego J. Rodriguez, Yossef Baidi, Annan Yang, William R. Sellers, Sidharth S. Jain, Dale Porter, Salvatore LaRussa, Alessandra Ianari, Josie Columbus, Zachary Mullin-Bernstein, Alissa J. Nelson, Brian J. McMillan
Publikováno v:
Mol Cell
PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP-null cancers. PRMT5 uses adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily conserved peptide sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c286957885746d63e5b3ac89688c8b85
https://europepmc.org/articles/PMC9016627/
https://europepmc.org/articles/PMC9016627/
Autor:
Kathleen M. Mulvaney, Brian McMillan, Christa Blomquist, Nischal Acharya, Matthew Ranaghan, Devishi Kesar, Alessandra Ianari, William Sellers
Publikováno v:
Cancer Research. 82:94-94
PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP-null cancers. PRMT5 uses adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily conserved peptide sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf9f1c3166d7c473855e974545b93f7c
https://doi.org/10.1158/1538-7445.am2022-94
https://doi.org/10.1158/1538-7445.am2022-94
Autor:
Ritu Singh, Michael F. Mesleh, Matthew J. Ranaghan, Virendar K. Kaushik, Dale Porter, Brian J. McMillan, Kathleen M. Mulvaney, Alessandra Ianari, David E. Timm, William R. Sellers, Besnik Bajrami, Patrick McCarren, Meghan O’Keefe, David C. McKinney, Merissa Brousseau, Zachary Mullin-Bernstein, Jamie A. Moroco, Adam Skepner
PRMT5 and its substrate adaptor proteins (SAPs), pICln and Riok1, are synthetic lethal dependencies in MTAP-deleted cancer cells. SAPs share a conserved PRMT5 binding motif (PBM) which mediates binding to a surface of PRMT5 distal to the catalytic si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b6860a9dce9163efa6957c5be29c743
https://doi.org/10.1101/2021.02.03.429644
https://doi.org/10.1101/2021.02.03.429644
Autor:
Yossef Baidi, Brian J. McMillan, Alissa J. Nelson, Josie Columbus, Sidharth S. Jain, Nischal Acharya, Matthew J. Ranaghan, Meghan O’Keefe, William R. Sellers, Kathleen M. Mulvaney, Yelena Freyzon, Fazli K. Bozal, Christa Blomquist, Ruitong Li, Adam Skepner, David C. McKinney, Dale Porter, Alessandra Ianari, Donald Raymond, Matthew E. Stokes
PRMT5 is an arginine methyltransferase and a therapeutic target in MTAP null cancers. PRMT5 utilizes adaptor proteins for substrate recruitment through a previously undefined mechanism. Here, we identify an evolutionarily conserved peptide sequence s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45336005291024a9907c2480940f06f2
https://doi.org/10.1101/2020.08.22.256347
https://doi.org/10.1101/2020.08.22.256347
Autor:
Bernard E. Weissman, Liza Makowski, Tigist Y. Tamir, Stephanie A. Montgomery, Seth J. Weir, Travis P. Schrank, Tuong T. Nguyen, Scott H. Randell, Travis S. Ptacek, D. Neil Hayes, Jeremy M. Simon, Kathleen M. Mulvaney, Brittany M. Bowman, Michael B. Major, Xiaoxin L Chen, Ryan M. Murphy
Publikováno v:
J Pathol
Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441e71dc1a72cc8706ac8773e1a87bb8
https://pubmed.ncbi.nlm.nih.gov/32619021
https://pubmed.ncbi.nlm.nih.gov/32619021
Publikováno v:
Current Opinion in Toxicology. 1:118-124
Mass spectrometry-based proteomic technologies continue to illuminate the mechanism(s) and physiological importance of the KEAP1/NRF2 antioxidant signaling pathway. Proteomic analysis of the KEAP1 and NRF2 protein complex has revealed associated prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8039c9db5eca1619ec97e4b2fb1b443b
https://doi.org/10.1016/j.cotox.2016.10.007
https://doi.org/10.1016/j.cotox.2016.10.007
Autor:
Cristina Pizarro-Irizar, Steven J. Smith, Rita Van Dingenen, Anil Markandya, Kathleen M. Mulvaney, Jon Sampedro, Iñaki Arto, Mikel González-Eguino
Publikováno v:
Environment International, Vol 136, Iss, Pp-(2020)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Addi. Archivo Digital para la Docencia y la Investigación
instname
This study assesses the reductions in air pollution emissions and subsequent beneficial health effects from different global mitigation pathways consistent with the 2 °C stabilization objective of the Paris Agreement. We use an integrated modelling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ab1aaf5cbc782b7ff0509e6080f134
https://pubmed.ncbi.nlm.nih.gov/32006762
https://pubmed.ncbi.nlm.nih.gov/32006762