Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Kathleen M. MacLeod"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86520 (2014)
The RhoA/ROCK pathway contributes to diabetic cardiomyopathy in part by promoting the sustained activation of PKCβ2 but the details of their interaction are unclear. The purpose of this study was to investigate if over-activation of ROCK in the diab
Externí odkaz:
https://doaj.org/article/456f7c79a5514677bc26ec1b8c747cb3
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
We read with interest your letter to the editor expressing concern about using ROCK2 inhibition for diabetic cardiomyopathy (DCM) management, as it may promote tumor metastasis and disturb some physiological functions. However, the effect of ROCK2 on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afab9b5b019ec7526f7acc215491701
http://hdl.handle.net/10261/206159
http://hdl.handle.net/10261/206159
Autor:
Martin Arostegui, Wilder Scott, Christina E. Barkauskas, Fabio M.V. Rossi, ChihKai Chang, Marcela Low, Kathleen M. MacLeod, Ben Paylor, T. Michael Underhill, Alessandra Rampazzo, Paola Braghetta, Dario R. Lemos, Hesham Soliman, Vendula Pospichalova, Daniela Fiore, Christina W. Lee, Vladimir Korinek
The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within cardiac stromal cells are still poorly understood. Here, we identify heart-resident PDGFRa+Sca-1+cells as cardiac Fibro/Adipogenic Progenitors (cFA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f10a0991d1d93c5ea946d95618de318
http://hdl.handle.net/11577/3330750
http://hdl.handle.net/11577/3330750
Publikováno v:
Experimental Models of Diabetes ISBN: 9780203756386
Experimental Models of Diabetes
Experimental Models of Diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e17d04f9c7727c1b180d5e1b08995b4
https://doi.org/10.1201/9780203756386-7
https://doi.org/10.1201/9780203756386-7
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 303:H989-H1000
We previously reported that acute inhibition of the RhoA/Rho kinase (ROCK) pathway normalized contractile function of diabetic rat hearts, but the underlying mechanism is unclear. Protein kinase C (PKC) β2 has been proposed to play a major role in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1ad94db0107e2a798379ead1056046
https://doi.org/10.1152/ajpheart.00416.2012
https://doi.org/10.1152/ajpheart.00416.2012
Autor:
Harish Vasudevan, Kathleen M. MacLeod, Padmesh S. Rajput, John H. McNeill, Ujendra Kumar, Prabhakara R Nagareddy, B McClure
Publikováno v:
British Journal of Pharmacology. 165:705-715
BACKGROUND AND PURPOSE Insulin resistance is often found to be associated with high blood pressure. We propose that in insulin-resistant hypertension, endothelial dysfunction is the consequence of increased activity of vascular MMP-2. As MMP-2 proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5be384358b8de3689acaa47d2850461f
https://doi.org/10.1111/j.1476-5381.2011.01583.x
https://doi.org/10.1111/j.1476-5381.2011.01583.x
Publikováno v:
Cardiovascular Research. 87:177-186
The presence of metabolic abnormalities such as insulin resistance and elevated levels of various vasoconstrictor G-protein-coupled receptor (GPCR) agonists contributes to the development of hypertension. Recent studies have suggested a link between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67ce4febfc0d713bf58f49a65269798
https://doi.org/10.1093/cvr/cvq030
https://doi.org/10.1093/cvr/cvq030
Autor:
Guorong Lin, Padmesh S. Rajput, Kathleen M. MacLeod, John H. McNeill, Hesham Soliman, Prabhakara R Nagareddy, Ujendra Kumar
Publikováno v:
Diabetes
OBJECTIVEImpaired cardiovascular function in diabetes is partially attributed to pathological overexpression of inducible nitric oxide synthase (iNOS) in cardiovascular tissues. We examined whether the hyperglycemia-induced increased expression of iN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743d25e76c00396b1479900ca3092546
https://doi.org/10.2337/db09-0432
https://doi.org/10.2337/db09-0432
Autor:
Carlos Fernandez-Patron, Li Hao, Tamiko Nishimura, John H. McNeill, Prabhakara R Nagareddy, Kathleen M. MacLeod, Fung L. Chow, Xiang Wang
Publikováno v:
Cardiovascular Research. 84:368-377
Aims G-protein-coupled receptors (GPCRs) modulate vascular tone, at least in part, via matrix metalloproteinase (MMP) transactivation of the epidermal growth factor receptor (EGFR). We previously have identified novel signalling pathways downstream o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e16ebdc090f74157eb8870970f8d74d
https://doi.org/10.1093/cvr/cvp230
https://doi.org/10.1093/cvr/cvp230
Publikováno v:
Journal of Molecular and Cellular Cardiology. 47:112-120
Lysophosphatidylcholine (LPC), a hydrolysis product of phospholipid degradation, accumulates in the ischemic myocardium. Using isolated hearts or rat coronary septal arteries, we tested the impact of LPC in modulating basal function or the responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c7a349e4e6635c7075e5e38048525a
https://doi.org/10.1016/j.yjmcc.2009.03.026
https://doi.org/10.1016/j.yjmcc.2009.03.026