Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Kathleen M. MacLeod"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86520 (2014)
The RhoA/ROCK pathway contributes to diabetic cardiomyopathy in part by promoting the sustained activation of PKCβ2 but the details of their interaction are unclear. The purpose of this study was to investigate if over-activation of ROCK in the diab
Externí odkaz:
https://doaj.org/article/456f7c79a5514677bc26ec1b8c747cb3
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
We read with interest your letter to the editor expressing concern about using ROCK2 inhibition for diabetic cardiomyopathy (DCM) management, as it may promote tumor metastasis and disturb some physiological functions. However, the effect of ROCK2 on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afab9b5b019ec7526f7acc215491701
http://hdl.handle.net/10261/206159
http://hdl.handle.net/10261/206159
Autor:
Martin Arostegui, Wilder Scott, Christina E. Barkauskas, Fabio M.V. Rossi, ChihKai Chang, Marcela Low, Kathleen M. MacLeod, Ben Paylor, T. Michael Underhill, Alessandra Rampazzo, Paola Braghetta, Dario R. Lemos, Hesham Soliman, Vendula Pospichalova, Daniela Fiore, Christina W. Lee, Vladimir Korinek
The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within cardiac stromal cells are still poorly understood. Here, we identify heart-resident PDGFRa+Sca-1+cells as cardiac Fibro/Adipogenic Progenitors (cFA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f10a0991d1d93c5ea946d95618de318
http://hdl.handle.net/11577/3330750
http://hdl.handle.net/11577/3330750
Autor:
Hesham Soliman, Zheng Ping Jia, Vongai Nyamandi, Marysol Garcia-Patino, Ping-Cheng Zhang, Kathleen M. MacLeod, Eric Lin, Leif Hove-Madsen, Glen F. Tibbits
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
INTERNATIONAL JOURNAL OF CARDIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
INTERNATIONAL JOURNAL OF CARDIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Background: Diabetes is associated with an increased risk of heart failure, cardiac arrhythmias and sudden cardiac death. We previously showed that ROCK2 expression is elevated in diabetic rat hearts, and that ROCK inhibition acutely improves their c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3734021511e5d09ccdaa28860d59e7ca
http://hdl.handle.net/10261/201764
http://hdl.handle.net/10261/201764
Publikováno v:
Experimental Models of Diabetes ISBN: 9780203756386
Experimental Models of Diabetes
Experimental Models of Diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e17d04f9c7727c1b180d5e1b08995b4
https://doi.org/10.1201/9780203756386-7
https://doi.org/10.1201/9780203756386-7
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 303:H989-H1000
We previously reported that acute inhibition of the RhoA/Rho kinase (ROCK) pathway normalized contractile function of diabetic rat hearts, but the underlying mechanism is unclear. Protein kinase C (PKC) β2 has been proposed to play a major role in d
Autor:
Harish Vasudevan, Kathleen M. MacLeod, Padmesh S. Rajput, John H. McNeill, Ujendra Kumar, Prabhakara R Nagareddy, B McClure
Publikováno v:
British Journal of Pharmacology. 165:705-715
BACKGROUND AND PURPOSE Insulin resistance is often found to be associated with high blood pressure. We propose that in insulin-resistant hypertension, endothelial dysfunction is the consequence of increased activity of vascular MMP-2. As MMP-2 proteo
Publikováno v:
Cardiovascular Research. 87:177-186
The presence of metabolic abnormalities such as insulin resistance and elevated levels of various vasoconstrictor G-protein-coupled receptor (GPCR) agonists contributes to the development of hypertension. Recent studies have suggested a link between
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:174
Autor:
Guorong Lin, Padmesh S. Rajput, Kathleen M. MacLeod, John H. McNeill, Hesham Soliman, Prabhakara R Nagareddy, Ujendra Kumar
Publikováno v:
Diabetes
OBJECTIVEImpaired cardiovascular function in diabetes is partially attributed to pathological overexpression of inducible nitric oxide synthase (iNOS) in cardiovascular tissues. We examined whether the hyperglycemia-induced increased expression of iN