Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kathleen M. Heinz-Taheny"'
Autor:
Adam Hargreaves, Rob Wallis, Derek J. Leishman, Louise Leong, Steven Engle, Lorna Ewart, David E. Watson, Kathleen M. Heinz-Taheny, Philip H. Milliken, Nick McMahon, Sarah Kirk, Peter Clements, Mike Aylott, Jean-Pierre Valentin, Magali Guffroy, Renaud Fleurance, Nick Edmunds
Publikováno v:
Toxicological Sciences. 176:224-235
Integrating nonclinical in vitro, in silico, and in vivo datasets holistically can improve hazard characterization and risk assessment. In pharmaceutical development, cardiovascular liabilities are a leading cause of compound attrition. Prior to clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2764b1583d31e2aea76a3e12dabc3e8
https://doi.org/10.1093/toxsci/kfaa051
https://doi.org/10.1093/toxsci/kfaa051
Autor:
Melissa A Bellinger, James S Bean, Melissa A Rader, Kathleen M Heinz-Taheny, Jairo S Nunes, Joseph V Haas, Laura F Michael, Mark D Rekhter
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93297 (2014)
BACKGROUND: Acute kidney injury (AKI) is a syndrome characterized by the rapid loss of the kidney excretory function and is strongly associated with increased early and long-term patient morbidity and mortality. Early diagnosis of AKI is challenging;
Externí odkaz:
https://doaj.org/article/ed5393dd682c48c7a0d43188c1bf53c0
Autor:
Josef G. Heuer, Raymond C. Harris, Shannon M Harlan, Jessica M. Overstreet, Matthew D. Breyer, Kathleen M. Heinz-Taheny
Publikováno v:
Toxicologic Pathology. 46:991-998
The ReninAAV db/db uNx model of diabetic kidney disease (DKD) exhibits hallmarks of advanced human disease, including progressive elevations in albuminuria and serum creatinine, loss of glomerular filtration rate, and pathological changes. Microarray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571525a2e18af81989566769bbc4804e
https://doi.org/10.1177/0192623318804986
https://doi.org/10.1177/0192623318804986
Autor:
Hui-Rong Qian, Tao Wei, Josef G. Heuer, Kathleen M. Heinz-Taheny, Shannon M Harlan, Derek D. Yang, John Morris Sullivan, Jeffrey S. Boyles, Dianna L. Jaqua, Matthew D. Breyer, Derrick R. Witcher, Jonathan M. Wilson
Publikováno v:
American Journal of Physiology-Renal Physiology. 312:F951-F962
Transforming growth factor-alpha (TGFA) has been shown to play a role in experimental chronic kidney disease associated with nephron reduction, while its role in diabetic kidney disease (DKD) is unknown. We show here that intrarenal TGFA mRNA express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b27ff6c3129951dd87e3467722c37a
https://doi.org/10.1152/ajprenal.00443.2016
https://doi.org/10.1152/ajprenal.00443.2016
Autor:
Diann Blanset, Maggie Dempster, Renaud Fleurance, Esther Sutter, Michael W. Leach, Timothy K. MacLachlan, Elizabeth Galbreath, Kathleen M. Heinz-Taheny, Laura Andrews, Anna Maria Giusti, Mary Ellen Cosenza, Joy A. Cavagnaro, Shari A. Price
Publikováno v:
Regulatory Toxicology and Pharmacology. 121:104872
Monoclonal antibodies (mAbs) and mAb derivatives have become mainstay pharmaceutical modalites. A critical assessment is to ascertain the specificity of these molecules prior to human clinical trials. The primary technique for determining specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad0a2670e20ca1eb2780cf9b882a8b8
https://doi.org/10.1016/j.yrtph.2021.104872
https://doi.org/10.1016/j.yrtph.2021.104872
Publikováno v:
Toxicologic pathology. 46(8)
Diabetes mellitus (types 1 and 2) is the leading cause of glomerular disease and end-stage renal disease in most developed countries, with estimates that one-third of people living with diabetes will develop diabetic kidney disease (DKD). The current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09fad6b9691b1286b9ffdb1a1b21172
https://pubmed.ncbi.nlm.nih.gov/30213245
https://pubmed.ncbi.nlm.nih.gov/30213245
Autor:
Martin S. Cramer, Dianna L. Jaqua, Shannon M Harlan, Hana E. Baker, Tao Wei, Josef G. Heuer, John Morris Sullivan, Zhonghua Qi, Kathleen M. Heinz-Taheny, Tatiyana L. Shiyanova, Matthew D. Breyer
Publikováno v:
Journal of the American Society of Nephrology : JASN. 29(2)
Progress in research and developing therapeutics to prevent diabetic kidney disease (DKD) is limited by a lack of animal models exhibiting progressive kidney disease. Chronic hypertension, a driving factor of disease progression in human patients, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7a72d7cbfb08aef738890769df7105
https://pubmed.ncbi.nlm.nih.gov/29061652
https://pubmed.ncbi.nlm.nih.gov/29061652
Autor:
Philip W. Iversen, Anne H. Dantzig, Susan E. Pratt, Robert L. Shepard, Sara Durland-Busbice, Kathleen M. Heinz-Taheny
Publikováno v:
Clinical Cancer Research. 19:1159-1168
Purpose: The oral prodrug of gemcitabine LY2334737 is cleaved systemically to gemcitabine; the mechanism responsible for hydrolysis is unknown. LY2334737 cytotoxicity was tested in the NCI-60 panel; mining of microarray expression data identified car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae27476ae67701ca4753cba10e5a1921
https://doi.org/10.1158/1078-0432.ccr-12-1184
https://doi.org/10.1158/1078-0432.ccr-12-1184
Autor:
Kathleen M. Heinz-Taheny
Publikováno v:
Veterinary Clinics of North America: Exotic Animal Practice. 12:39-50
The class Amphibia includes three orders of amphibians: the anurans (frogs and toads), urodeles (salamanders, axolotls, and newts), and caecilians. The diversity of lifestyles across these three orders has accompanying differences in the cardiovascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23504ffad24cb08329b7fb3272a0761
https://doi.org/10.1016/j.cvex.2008.08.005
https://doi.org/10.1016/j.cvex.2008.08.005
Autor:
Robert J. Novak, Tanasa S. Osborne, Carol A. Lichtensteiger, Margaret L. Firth, Kathleen M. Heinz-Taheny, Beth A. Lewis
Publikováno v:
Emerging Infectious Diseases, Vol 9, Iss 10, Pp 1303-1306 (2003)
Emerging Infectious Diseases
Emerging Infectious Diseases
Since its 1999 introduction in New York, West Nile virus (WNV) has spread to >40 states, causing seasonal mosquito-borne disease in humans, horses, and birds (1–7). We recently identified two Illinois canids (a captive wolf and a domestic dog) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae6ef4a69b4decce1a96e12b860d9a5
https://wwwnc.cdc.gov/eid/article/9/10/02-0617_article
https://wwwnc.cdc.gov/eid/article/9/10/02-0617_article