Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kathleen M. Giangiacomo"'
Autor:
Kathleen M. Giangiacomo, Maria L. Garcia, Ying-Duo Gao, Theodore J. Mullmann, William A. Schmalhofer, Nathan E. Schroeder
Publikováno v:
FEBS Letters. 527:298-302
Iberiotoxin (IbTX) is a remarkably selective alpha-K toxin peptide (alpha-KTx) inhibitor of the maxi-K channel. In contrast, the highly homologous charybdotoxin inhibits both the maxi-K and K(V)1.3 channels with similar high affinity. The present stu
Autor:
Theodore J. Mullmann, Gilles Ferrat, Kathleen M. Giangiacomo, Herve Darbon, Valerie Fremont, Cedric Bernard
Publikováno v:
Biochemistry. 40:10998-11006
Noxiustoxin (NxTX) and iberiotoxin (IbTX) exhibit extraordinary differences in their ability to inhibit current through the large-conductance calcium-activated potassium (maxi-K) and voltage-gated potassium (Kv1.3) channels. The three-dimensional str
Autor:
Theodore J. Mullmann, Kathleen M. Giangiacomo, Robert H. Cox, Maria L. Garcia, Valerie Fremont, Markus Hanner
Publikováno v:
Biochemistry. 39:6115-6122
The maxi-K channel from bovine aortic smooth muscle consists of a pore-forming alpha subunit and a regulatory beta1 subunit that modifies the biophysical and pharmacological properties of the alpha subunit. In the present study, we examine ChTX-S10A
Publikováno v:
Biochemistry. 38:2395-2402
Iberiotoxin (IbTX or alpha-KTx 1.3), a selective, high-affinity blocker of the large-conductance, calcium-activated (maxi-K) channel, exhibits a unique, asymmetric distribution of charge. To test how these charges control kinetics of IbTX binding, we
Publikováno v:
Perspectives in Drug Discovery and Design. :167-186
This review examines recent work aimed at revealing the molecular structures of the potassium channel vestibules using the α-K toxin (α-KTx) peptide blockers from the venoms of scorpions. The three subfamilies of α-K toxins are discussed in terms
Autor:
Hans-Günther Knaus, Theodore J. Mullmann, Kathleen M. Giangiacomo, Owen B. McManus, Margarita Garcia-Calvo, Maria L. Garcia
Publikováno v:
Biochemistry. 34:15849-15862
The charybdotoxin (ChTX) receptor has been purified from bovine aortic smooth muscle using conventional chromatographic techniques and sucrose gradient centrifugation. Fractions from the final sucrose gradient purification were enriched in specific b
Autor:
Lisa M. H. Helms, Hans-Günther Knaus, S H Lee, Kathleen M. Giangiacomo, Owen B. McManus, Manuel Sanchez, Margarita Garcia-Calvo, William A. Schmalhofer, J P Reuben, A B Smith rd
Publikováno v:
Biochemistry. 33:5819-5828
Tremorgenic indole alkaloids produce neurological disorders (e.g., staggers syndromes) in ruminants. The mode of action of these fungal mycotoxins is not understood but may be related to their known effects on neurotransmitter release. To determine w
Autor:
Gregory J. Kaczorowski, Hans-Günther Knaus, Owen B. McManus, Kathleen M. Giangiacomo, Margarita Garcia-Calvo, Maria L. Garcia
Publikováno v:
Journal of Biological Chemistry. 269:676-682
The high-conductance Ca(2+)-activated K+ (maxi-K) channel from bovine tracheal smooth muscle was purified to apparent homogeneity by a combination of conventional chromatographic techniques and sucrose density gradient centrifugation. Fractions with
Autor:
Reid J. Leonard, Maria L. Garcia, Gregory J. Kaczorowski, Margarita Garcia-Calvo, Elizabeth E. Sugg, Kathleen M. Giangiacomo, Owen B. McManus
Publikováno v:
Biochemistry. 32:2363-2370
Charybdotoxin (ChTX) and iberiotoxin (IbTX) are highly charged peptidyl toxins which exhibit 68% sequence identity and share a similar three-dimensional structure. Despite these structural similarities, IbTX and ChTX differ in their selectivity for t
Autor:
Maria L. Garcia, Theodore J. Mullmann, Kathleen M. Giangiacomo, Christopher Garsky, Jennifer Becker, William A. Schmalhofer
Publikováno v:
Cell biochemistry and biophysics. 52(1)
The alpha-KTx peptide toxins inhibit different types of potassium channels by occluding the outer channel pore composed of four identical alpha subunits. The large-conductance, calcium-activated (BK or Slo1) and voltage-dependent (KV) potassium chann