Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Kathleen M. Cunningham"'
Autor:
Julyun Oh, Charles Kirsh, Jing-Ping Hsin, Kelly C. Radecki, Alexandre Zampieri, Diane Manry, Yuta Ando, Sara Miller, Jamie Chan, Ethan McLeod, Kathleen M. Cunningham, Lu Min Wong, Han Xu, Alexander Kamb
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109913- (2024)
Summary: Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E) which are widely expressed on cancer cells. Noncancerous cells—despite high expre
Externí odkaz:
https://doaj.org/article/2f54004c83044be5bd8ac35ee92cdfc3
Autor:
Kathleen M Cunningham, Kirstin Maulding, Kai Ruan, Mumine Senturk, Jonathan C Grima, Hyun Sung, Zhongyuan Zuo, Helen Song, Junli Gao, Sandeep Dubey, Jeffrey D Rothstein, Ke Zhang, Hugo J Bellen, Thomas E Lloyd
Publikováno v:
eLife, Vol 9 (2020)
Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which disrupted NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified ref(2)P/p62, a ke
Externí odkaz:
https://doaj.org/article/1a36dcfe2f884b73b4686aa681abb4ea
Autor:
Vivien Sauer, Kathleen M. Cunningham, Charles Choi, D. Leanne Jones, S. Mateo Ruvalcaba, Martin Resnik-Docampo
Publikováno v:
Stem cell reports, vol 16, iss 6
Stem Cell Reports
Stem Cell Reports
Summary The Drosophila intestine is an excellent system for elucidating mechanisms regulating stem cell behavior. Here we show that the septate junction (SJ) protein Neuroglian (Nrg) is expressed in intestinal stem cells (ISCs) and enteroblasts (EBs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abe5c361bf2fceaf71c80a373a94865
https://escholarship.org/uc/item/1g1625qv
https://escholarship.org/uc/item/1g1625qv
Author response: TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS
Autor:
Kai Ruan, Zhongyuan Zuo, Sandeep Dubey, Ke Zhang, Thomas E. Lloyd, Mumine Senturk, Helen Song, Hugo J. Bellen, Junli Gao, Hyun Sung, Jonathan C. Grima, Kirstin Maulding, Jeffrey D. Rothstein, Kathleen M. Cunningham
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::628c9af1fc3f51da73905796f2e4344e
https://doi.org/10.7554/elife.59419.sa2
https://doi.org/10.7554/elife.59419.sa2
Autor:
S. Mateo Ruvalcaba, Kathleen M. Cunningham, Vivien Sauer, Martin Resnik-Docampo, Charles Choi, D. Leanne Jones
SummaryTheDrosophila melanogasterintestine is an excellent system for elucidating mechanisms regulating stem cell behavior under homeostatic conditions or in response to injury, stress, or ageing. Here we show that the septate junction (SJ) protein N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4921d39d6a2b7ea498de2b4e76a3c763
https://doi.org/10.1101/2020.11.17.385781
https://doi.org/10.1101/2020.11.17.385781
Autor:
Hugo J. Bellen, Ke Zhang, Jeffrey D. Rothstein, Helen Song, Jonathan C. Grima, Kai Ruan, Kathleen M. Cunningham, Mumine Senturk, Zhongyuan Zuo, Hyun Sung, Kirstin Maulding, Thomas E. Lloyd
Disrupted nucleocytoplasmic transport (NCT) has been implicated in neurodegenerative disease pathogenesis; however, the mechanisms by which impaired NCT causes neurodegeneration remain unclear. In a Drosophila screen, we identified Ref(2)p/p62, a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02f841ea349ec7d72590b29d0fe7c90d
https://doi.org/10.1101/2020.06.26.173021
https://doi.org/10.1101/2020.06.26.173021
Publikováno v:
Human Molecular Genetics. 25:681-692
FIG4 is a phosphoinositide phosphatase that is mutated in several diseases including Charcot-Marie-Tooth Disease 4J (CMT4J) and Yunis-Varon syndrome (YVS). To investigate the mechanism of disease pathogenesis, we generated Drosophila models of FIG4-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decdb8988b679ab522d5660551d0c201
https://doi.org/10.1093/hmg/ddv505
https://doi.org/10.1093/hmg/ddv505
Autor:
Dipali Sharma, Arumugam Nagalingam, Gangavaram V. M. Sharma, Helmut M. Hügel, Kandikonda Suresh Kumar, Kathleen M. Cunningham, Sanjay V. Malhotra, Sheri Venkat Reddy, Ramesh Ummanni
Publikováno v:
Current Bioactive Compounds. 13
Background: Triazole based drugs are widely used in cancer patients for the treatment of life-threatening invasive fungal infections. A recent report on the usefulness of 1,2, 3- triazole scaffold for the inhibition of tyrosine kinases stimulated our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d064ba9eb257fd52306636398062052b
https://doi.org/10.2174/1573407213666161128122552
https://doi.org/10.2174/1573407213666161128122552
Autor:
Ke Zhang, Aaron D. Gitler, J. Paul Taylor, Kai Ruan, Jonathan C. Grima, Jeffrey D. Rothstein, Peiguo Yang, Thomas E. Lloyd, Alyssa N. Coyne, Harsh Wadhwa, J. Gavin Daigle, Frank Rigo, Kathleen M. Cunningham, Kelly Bowen
Publikováno v:
Cell. 173:958-971.e17
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a GGGGCC hexanucleotide repeat expansion in C9ORF72, the most common genetic ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abad46483237431ad11f097070c48fe
https://doi.org/10.1016/j.cell.2018.03.025
https://doi.org/10.1016/j.cell.2018.03.025
Autor:
Michael J. Matunis, Saksham Gupta, Jiou Wang, Elizabeth L. Daley, Richard L. Huganir, Kathleen M. Cunningham, Shu Ling Chiu, Michael A. Thomas, Jeffrey D. Rothstein, Christopher J. Donnelly, Lyle W. Ostrow, Thomas E. Lloyd, Aaron R. Haeusler, Sean J. Miller, Ke Zhang, Svetlana Vidensky, James B. Machamer, Peter Steinwald, Rita Sattler, Jonathan C. Grima, Ingie Hong
Publikováno v:
Nature. 525(7567)
The hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent studies support an HRE RNA gain-of-function mechanism of neurotoxicity, and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8919a5f671a4864641760c1357a234
https://pubmed.ncbi.nlm.nih.gov/26526532
https://pubmed.ncbi.nlm.nih.gov/26526532