Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kathleen M. Broughton"'
Autor:
Jack F. Murphy, Joshua Mayourian, Francesca Stillitano, Sadek Munawar, Kathleen M. Broughton, Esperanza Agullo-Pascual, Mark A. Sussman, Roger J. Hajjar, Kevin D. Costa, Irene C. Turnbull
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Background Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap between species, we investi
Externí odkaz:
https://doaj.org/article/9a9bde06e28e4ec3b138f70b770bbe62
Autor:
Nan Liu, Bingyan J Wang, Kathleen M Broughton, Roberto Alvarez, Sailay Siddiqi, Rebeca Loaiza, Nicky Nguyen, Pearl Quijada, Natalie Gude, Mark A Sussman
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173963 (2017)
PIM1, a pro-survival gene encoding a serine/ threonine kinase, influences cell proliferation and survival. Modification of cardiac progenitor cells (CPCs) or cardiomyocytes with PIM1 using a lentivirus-based delivery method showed long-term improved
Externí odkaz:
https://doaj.org/article/375ca4ddb5724a1b88f7feee99257ba0
Autor:
Mark A. Sussman, Kathleen M. Broughton
Publikováno v:
J Muscle Res Cell Motil
Researchers continue to develop therapeutic products for the repair and replacement of myocardial tissue that demonstrates contractility equivalent to normal physiologic states. As clinical trials focused on pure adult stem cell populations undergo m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec80166d2f8ff674593186774103535a
https://doi.org/10.1007/s10974-019-09570-6
https://doi.org/10.1007/s10974-019-09570-6
Publikováno v:
Circulation. 144
Introduction: Declining cellular functional capacity resulting from stress or aging is a primary contributor to impairment of myocardial performance. Molecular pathway regulation of biological processes in cardiac interstitial cells (CICs) is pivotal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc2636d34424cc5aca84eeb54ab819e1
https://doi.org/10.1161/circ.144.suppl_1.12245
https://doi.org/10.1161/circ.144.suppl_1.12245
Autor:
Mark A. Sussman, Kathleen M. Broughton
Publikováno v:
Trends Endocrinol Metab
Ability to promote completion of mitotic cycling of adult mammalian cardiomyocytes remains an intractable and vexing challenge, despite being one of the most sought after ‘holy grails’ of cardiovascular research. While some of the struggle is att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d2a60fd41c80b46ac0020ceedbe34c
https://doi.org/10.1016/j.tem.2019.05.006
https://doi.org/10.1016/j.tem.2019.05.006
Autor:
Monica Chavarria, Roberto Alvarez, Pearl Quijada, Kathleen M. Broughton, Megan M. Monsanto, Thi Ho, Mark A. Sussman, Maya Shaitrit, David E. Ebeid, Natalie Navarrete, Bingyan J. Wang, Maryam Moshref, Daniele Avitabile, Barbara A. Bailey, Fareheh Firouzi, Natalie Gude, Sailay Siddiqi
Publikováno v:
Journal of Molecular and Cellular Cardiology. 127:154-164
Rationale Understanding and manipulating the cardiomyocyte cell cycle has been the focus of decades of research, however the ultimate goal of activating mitotic activity in adult mammalian cardiomyocytes remains elusive and controversial. The relentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b0e44cc916229b3b541f8e9af72578
https://doi.org/10.1016/j.yjmcc.2018.12.007
https://doi.org/10.1016/j.yjmcc.2018.12.007
Autor:
Fareheh Firouzi, Kathleen M. Broughton, Sarmistha Sinha Choudhury, Adriana Salazar, Barbara A. Bailey, Mark A. Sussman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background CardioChimeras produced by fusion of murine c‐kit + cardiac interstitial cells with mesenchymal stem cells promote superior structural and functional recovery in a mouse model of myocardial infarction compared with either precursor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22b55f79e2bcbc7984a21bc527d41b7
https://pubmed.ncbi.nlm.nih.gov/31902324
https://pubmed.ncbi.nlm.nih.gov/31902324
Autor:
Joshua Mayourian, Roger J. Hajjar, Francesca Stillitano, Kevin D. Costa, Irene C. Turnbull, Mark A. Sussman, Esperanza Agulló-Pascual, Jack F Murphy, Sadek Munawar, Kathleen M. Broughton
Publikováno v:
Stem cell research & therapy, vol 10, iss 1
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Background Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap between species, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5aa9734bb5aeaa7313b6bcd4d287419
https://escholarship.org/uc/item/2200h15b
https://escholarship.org/uc/item/2200h15b
Publikováno v:
Nature Reviews Cardiology. 15:523-542
Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular level, ageing entails decreased replicative capacity and dysregulation of cellular processes in myocardial and nonmyocyte cells. Various extrinsic parameters,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb32db80eb228739599db7f632ec354
https://doi.org/10.1038/s41569-018-0061-5
https://doi.org/10.1038/s41569-018-0061-5
Autor:
Megan M. Monsanto, Veronica Sacchi, Christina R. Payne, Natalie Gude, Walter P. Dembitsky, Kristine Nguyen, Fareheh Firouzi, David E. Ebeid, Barbara A. Bailey, Jop H. van Berlo, Mark A. Sussman, Alexandria Casillas, Farid G. Khalafalla, Roberto Alvarez, Kathleen M. Broughton, Kelli Ilves, Bingyan J. Wang
Publikováno v:
Circulation Research. 123:57-72
Rationale: Biological significance of c-Kit as a cardiac stem cell marker and role(s) of c-Kit+ cells in myocardial development or response to pathological injury remain unresolved because of varied and discrepant findings. Alternative experimental m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c14256900de781ebedc989826a126ed
https://doi.org/10.1161/circresaha.117.311828
https://doi.org/10.1161/circresaha.117.311828