Výsledky vyhledávání - "Kathleen M Hoch"

Akademický článek

Assessment of the gut bacterial microbiome and metabolome of girls and women with Rett Syndrome.

Autor: Santosh Thapa, Alamelu Venkatachalam, Nabeel Khan, Mohammed Naqvi, Miriam Balderas, Jessica K Runge, Anthony Haag, Kathleen M Hoch, Daniel G Glaze, Ruth Ann Luna, Kathleen J Motil

Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0251231 (2021)

BackgroundGastrointestinal problems affect the health and quality of life of individuals with Rett syndrome (RTT) and pose a medical hardship for their caregivers. We hypothesized that the variability in the RTT phenotype contributes to the dysbiosis

Externí odkaz: https://doaj.org/article/232372eb776e44c49e47fc33ba90da56

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Akademický článek

Bacteroides ovatus colonization influences the abundance of intestinal short chain fatty acids and neurotransmitters

Autor: Thomas D. Horvath, Faith D. Ihekweazu, Sigmund J. Haidacher, Wenly Ruan, Kristen A. Engevik, Robert Fultz, Kathleen M. Hoch, Ruth Ann Luna, Numan Oezguen, Jennifer K. Spinler, Anthony M. Haag, James Versalovic, Melinda A. Engevik

Publikováno v: iScience, Vol 25, Iss 5, Pp 104158- (2022)

Summary: Gut microbes can synthesize multiple neuro-active metabolites. We profiled neuro-active compounds produced by the gut commensal Bacteroides ovatus in vitro and in vivo by LC-MS/MS. We found that B. ovatus generates acetic acid, propionic aci

Externí odkaz: https://doaj.org/article/9265eb55b5e3455eacfd6e2f6f4ffdf8

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Akademický článek

Insights into Microbiome and Metabolic Signatures of Children Undergoing Peanut Oral Immunotherapy

Autor: Andrea C. Blackman, Santosh Thapa, Alamelu Venkatachalam, Thomas D. Horvath, Jessica K. Runge, Sigmund J. Haidacher, Kathleen M. Hoch, Anthony M. Haag, Ruth Ann Luna, Aikaterini Anagnostou

Publikováno v: Children, Vol 9, Iss 8, p 1192 (2022)

Background: Peanut oral immunotherapy has emerged as a novel, active management approach for peanut-allergic sufferers, but limited data exist currently on the role of the microbiome in successful desensitization. Objective: We examined the oral and

Externí odkaz: https://doaj.org/article/5cc622f0176e407280dfa3934dfe6efe

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Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation

Autor: Melinda A. Engevik, Zhongcheng Shi, James Versalovic, Faith D. Ihekweazu, Kathleen M. Hoch, Anthony M. Haag, Jennifer K. Spinler, Deborah Schady, Wenly Ruan, Sigmund J. Haidacher, Beatrice Herrmann, Magdalena Esparza, Susan Venable, Alexandra Chang-Graham, Joseph M. Hyser, Amy C. Engevik, Thomas D. Horvath, Kristen A. Engevik, Berkley Luck

Publikováno v: Gut Microbes
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)

Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can beneficially modulate mucin production, little work has been done investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b384d892337b7c20e75ac6b8deec7b
http://europepmc.org/articles/PMC8128206

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Validation of atovaquone plasma levels by liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring in pediatric patients

Autor: Thomas D. Horvath, Izmarie Poventud-Fuentes, Lily Olayinka, Asha James, Sigmund J. Haidacher, Kathleen M. Hoch, Alexandra M. Stevens, Anthony M. Haag, Sridevi Devaraj

Publikováno v: Journal of mass spectrometry and advances in the clinical lab. 26

Atovaquone has traditionally been used as an antiparasitic and antifungal agent, but recent studies have shown its potential as an anticancer agent. The high variability in atovaquone bioavailability highlights the need for therapeutic drug monitorin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0e888ade20658ab8a6eb57efebbc9c
https://pubmed.ncbi.nlm.nih.gov/36388060

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Unraveling the Metabolic Requirements of the Gut Commensal Bacteroides ovatus

Autor: Robert Fultz, Taylor Ticer, Faith D. Ihekweazu, Thomas D. Horvath, Sigmund J. Haidacher, Kathleen M. Hoch, Meghna Bajaj, Jennifer K. Spinler, Anthony M. Haag, Shelly A. Buffington, Melinda A. Engevik

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

Background: Bacteroidetes are the most common bacterial phylum in the mammalian intestine and the effects of several Bacteroides spp. on multiple facets of host physiology have been previously described. Of the Bacteroides spp., Bacteroides ovatus ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::f70e35375a78dde53918dc030859fed8
https://www.frontiersin.org/articles/10.3389/fmicb.2021.745469/full

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Serum 3-phenyllactic acid level is reduced in benign multiple sclerosis and is associated with effector B cell ratios

Autor: Numan Oezguen, Vuslat Yılmaz, Thomas D. Horvath, Ece Akbayir, Sigmund J. Haidacher, Kathleen M. Hoch, Santosh Thapa, Jeremy Palacio, Recai Türkoğlu, Murat Kürtüncü, Melinda A. Engevik, James Versalovic, Anthony M. Haag, Erdem Tüzün

Publikováno v: Multiple Sclerosis and Related Disorders. 68:104239

3-phenyllactic acid (PLA) is produced by both intestinal bacteria and the human host. PLA exists in its D- and L- chiral forms. It modulates human immune functions, thereby acting as a mediator of bacterial-host interactions. We aim to determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78569c4086d0febf5410a441ad98f0cd
https://doi.org/10.1016/j.msard.2022.104239

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