Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Kathleen M, Trybus"'
Autor:
Dihia Moussaoui, James P. Robblee, Julien Robert-Paganin, Daniel Auguin, Fabio Fisher, Patricia M. Fagnant, Jill E. Macfarlane, Julia Schaletzky, Eddie Wehri, Christoph Mueller-Dieckmann, Jake Baum, Kathleen M. Trybus, Anne Houdusse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Malaria results in more than 500,000 deaths per year and the causative Plasmodium parasites continue to develop resistance to all known agents, including different antimalarial combinations. The class XIV myosin motor PfMyoA is part of a cor
Externí odkaz:
https://doaj.org/article/649b74fa0af0445585a6975102ee7c70
Autor:
Julien Robert-Paganin, Xiao-Ping Xu, Mark F. Swift, Daniel Auguin, James P. Robblee, Hailong Lu, Patricia M. Fagnant, Elena B. Krementsova, Kathleen M. Trybus, Anne Houdusse, Niels Volkmann, Dorit Hanein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Plasmodium falciparum moves by an atypical process called gliding motility which comprises of atypical myosin A (PfMyoA) and filaments of the dynamic and divergent PfActin-1 (PfAct1). Here authors present the cryo-EM structure of PfMyoA bound to fila
Externí odkaz:
https://doaj.org/article/1e9f084757d3479aa82cffe48fcd9158
Autor:
James M Gibson, Heying Cui, M Yusuf Ali, Xiaoxin Zhao, Erik W Debler, Jing Zhao, Kathleen M Trybus, Sozanne R Solmaz, Chunyu Wang
Publikováno v:
eLife, Vol 11 (2022)
Nup358, a protein of the nuclear pore complex, facilitates a nuclear positioning pathway that is essential for many biological processes, including neuromuscular and brain development. Nup358 interacts with the dynein adaptor Bicaudal D2 (BicD2), whi
Externí odkaz:
https://doaj.org/article/4a68972630e44150a18ff81e5f7a70b2
Autor:
Julien Robert-Paganin, James P. Robblee, Daniel Auguin, Thomas C. A. Blake, Carol S. Bookwalter, Elena B. Krementsova, Dihia Moussaoui, Michael J. Previs, Guillaume Jousset, Jake Baum, Kathleen M. Trybus, Anne Houdusse
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Here, Robert-Paganin et al. show that myosin A from Plasmodium falciparum is critical for red blood cell invasion and that non-canonical interactions and regulated phosphorylation are important for force generation during parasite invasion.
Externí odkaz:
https://doaj.org/article/09a7260cc76747dbb13cb2f561bcbfc8
Autor:
Dihia Moussaoui, James P Robblee, Daniel Auguin, Elena B Krementsova, Silvia Haase, Thomas CA Blake, Jake Baum, Julien Robert-Paganin, Kathleen M Trybus, Anne Houdusse
Publikováno v:
eLife, Vol 9 (2020)
Parasites from the genus Plasmodium are the causative agents of malaria. The mobility, infectivity, and ultimately pathogenesis of Plasmodium falciparum rely on a macromolecular complex, called the glideosome. At the core of the glideosome is an esse
Externí odkaz:
https://doaj.org/article/b65c35d6ff964fcd82d2f940374cef22
Autor:
Dennis Zimmermann, Kaitlin E. Homa, Glen M. Hocky, Luther W. Pollard, Enrique M. De La Cruz, Gregory A. Voth, Kathleen M. Trybus, David R. Kovar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin fil
Externí odkaz:
https://doaj.org/article/bc76ecd9ae8c4d8a8269a508fded3c34
Autor:
Andrew T. Lombardo, Shane R. Nelson, M. Yusuf Ali, Guy G. Kennedy, Kathleen M. Trybus, Sam Walcott, David M. Warshaw
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-
Externí odkaz:
https://doaj.org/article/9cbbb6d752f74a68bb343e25f12b6f66
Autor:
Marco Tjioe, Saurabh Shukla, Rohit Vaidya, Alice Troitskaia, Carol S Bookwalter, Kathleen M Trybus, Yann R Chemla, Paul R Selvin
Publikováno v:
eLife, Vol 8 (2019)
How cargoes move within a crowded cell—over long distances and at speeds nearly the same as when moving on unimpeded pathway—has long been mysterious. Through an in vitro force-gliding assay, which involves measuring nanometer displacement and pi
Externí odkaz:
https://doaj.org/article/f0cfc80e1764485691084dfbb2a346d0
Autor:
Thomas E Sladewski, Neil Billington, M Yusuf Ali, Carol S Bookwalter, Hailong Lu, Elena B Krementsova, Trina A Schroer, Kathleen M Trybus
Publikováno v:
eLife, Vol 7 (2018)
We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules. Full-length BicD robustly activated dynein-dynactin motility only when both the mRNA binding prote
Externí odkaz:
https://doaj.org/article/31c5caaefb134acaa7f972fe1db55b73
It was proposed from cellular studies thatS. pombetropomyosin Cdc8 (Tpm) segregates into two populations due to the presence or absence of an amino-terminal acetylation that specifies which formin-mediated F-actin networks it binds, but with no suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbfd9d000f1eae659e56d40cdf19a7e
https://doi.org/10.1101/2022.11.03.514925
https://doi.org/10.1101/2022.11.03.514925
