Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Kathleen M, Schmainda"'
Autor:
Leland S. Hu, Fulvio D’Angelo, Taylor M. Weiskittel, Francesca P. Caruso, Shannon P. Fortin Ensign, Mylan R. Blomquist, Matthew J. Flick, Lujia Wang, Christopher P. Sereduk, Kevin Meng-Lin, Gustavo De Leon, Ashley Nespodzany, Javier C. Urcuyo, Ashlyn C Gonzales, Lee Curtin, Erika M. Lewis, Kyle W. Singleton, Timothy Dondlinger, Aliya Anil, Natenael B. Semmineh, Teresa Noviello, Reyna A. Patel, Panwen Wang, Junwen Wang, Jennifer M. Eschbacher, Andrea Hawkins-Daarud, Pamela R. Jackson, Itamar S. Grunfeld, Christian Elrod, Gina L. Mazza, Sam C. McGee, Lisa Paulson, Kamala Clark-Swanson, Yvette Lassiter-Morris, Kris A. Smith, Peter Nakaji, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Devi P. Patra, Naresh P. Patel, Mark Lyons, Matthew Neal, Kliment Donev, Maciej M. Mrugala, Alyx B. Porter, Scott C. Beeman, Todd R. Jensen, Kathleen M. Schmainda, Yuxiang Zhou, Leslie C. Baxter, Christopher L. Plaisier, Jing Li, Hu Li, Anna Lasorella, C. Chad Quarles, Kristin R. Swanson, Michele Ceccarelli, Antonio Iavarone, Nhan L. Tran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Sampling restrictions have hindered the comprehensive study of invasive non-enhancing (NE) high-grade glioma (HGG) cell populations driving tumor progression. Here, we present an integrated multi-omic analysis of spatially matched molecular
Externí odkaz:
https://doaj.org/article/a2809ec273b7446289807a553cea6a7f
Autor:
Melissa A. Prah, Kathleen M. Schmainda
Publikováno v:
Frontiers in Radiology, Vol 4 (2024)
Relative cerebral blood volume (rCBV) derived from dynamic susceptibility contrast (DSC) perfusion MR imaging (pMRI) has been shown to be a robust marker of neuroradiological tumor burden. Recent consensus recommendations in pMRI acquisition strategi
Externí odkaz:
https://doaj.org/article/fcb6f719df8544ddb79e232d3d72f108
Autor:
Mona M. Al-Gizawiy, Robert T. Wujek, Hisham S. Alhajala, Jonathan M. Cobb, Melissa A. Prah, Ninh B. Doan, Jennifer M. Connelly, Christopher R. Chitambar, Kathleen M. Schmainda
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
BackgroundTreatment-resistant glioblastoma (trGBM) is an aggressive brain tumor with a dismal prognosis, underscoring the need for better treatment options. Emerging data indicate that trGBM iron metabolism is an attractive therapeutic target. The no
Externí odkaz:
https://doaj.org/article/2a555886013f4c458fa6a633cc888fe1
Autor:
Mark S. Shiroishi, Dane Weinert, Steven Y. Cen, Bino Varghese, Timothy Dondlinger, Melissa Prah, Jesse Mendoza, Sina Nazemi, Nima Ameli, Negin Amini, Salman Shohas, Shannon Chen, Bavrina Bigjahan, Gabriel Zada, Thomas Chen, Josh Neman-Ebrahim, Eric L. Chang, Frances E. Chow, Zhaoyang Fan, Wensha Yang, Frank J. Attenello, Jason Ye, Paul E. Kim, Vishal N. Patel, Alexander Lerner, Jay Acharya, Leland S. Hu, C. Chad Quarles, Jerrold L. Boxerman, Ona Wu, Kathleen M. Schmainda
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Introduction1.5 Tesla (1.5T) remain a significant field strength for brain imaging worldwide. Recent computer simulations and clinical studies at 3T MRI have suggested that dynamic susceptibility contrast (DSC) MRI using a 30° flip angle (“low-FA
Externí odkaz:
https://doaj.org/article/a7bc0151dca8406688b76c2a967c274a
Autor:
Thomas P. Reith, Melissa A. Prah, Eun-Jung Choi, Jongho Lee, Robert Wujek, Mona Al-Gizawiy, Christopher R. Chitambar, Jennifer M. Connelly, Kathleen M. Schmainda
Publikováno v:
Tomography, Vol 8, Iss 2, Pp 789-797 (2022)
Background and Purpose: Gliomas have been found to alter iron metabolism and transport in ways that result in an expansion of their intracellular iron compartments to support aggressive tumor growth. This study used deep neural network trained quanti
Externí odkaz:
https://doaj.org/article/c72e44ac928348199a3a0612c131e965
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundProgressive enhancement predicted poor survival in ACRIN 6677/RTOG 0625, a multi-center trial of bevacizumab with irinotecan or temozolomide in recurrent glioblastoma, but pseudoresponse likely limited enhancement-based survival prognostica
Externí odkaz:
https://doaj.org/article/e617ec5df0b8426884a2d978ad1992ed
Autor:
Ryan F. Amidon, Fernando Santos-Pinheiro, Michael Straza, Melissa A. Prah, Wade M. Mueller, Max O. Krucoff, Jennifer M. Connelly, Christopher J. Kleefisch, Dylan J. Coss, Elizabeth J. Cochran, Joseph A. Bovi, Christopher J. Schultz, Kathleen M. Schmainda
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundPulsed low-dose-rate radiotherapy (pLDR) is a commonly used reirradiation technique for recurrent glioma, but its upfront use with temozolomide (TMZ) following primary resection of glioblastoma is currently under investigation. Because stan
Externí odkaz:
https://doaj.org/article/f190ea877cbf494895ac42923a91f64c
Autor:
Shiliang Huang, Joel E. Michalek, David A. Reardon, Patrick Y. Wen, John R. Floyd, Peter T. Fox, Geoffrey D. Clarke, Paul A. Jerabek, Kathleen M. Schmainda, Mark Muzi, Hyewon Hyun, Eudocia Quant Lee, Andrew J. Brenner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Tumoral hypoxia correlates with worse outcomes in glioblastoma (GBM). While bevacizumab is routinely used to treat recurrent GBM, it may exacerbate hypoxia. Evofosfamide is a hypoxia-targeting prodrug being tested for recurrent GBM. To chara
Externí odkaz:
https://doaj.org/article/deb48a83797b4c008592d78912bc5b5d
Autor:
Dania G. Malik, Tanya J. Rath, Javier C. Urcuyo Acevedo, Peter D. Canoll, Kristin R. Swanson, Jerrold L. Boxerman, C. Chad Quarles, Kathleen M. Schmainda, Terry C. Burns, Leland S. Hu
Publikováno v:
Frontiers in Radiology, Vol 2 (2022)
In the follow-up treatment of high-grade gliomas (HGGs), differentiating true tumor progression from treatment-related effects, such as pseudoprogression and radiation necrosis, presents an ongoing clinical challenge. Conventional MRI with and withou
Externí odkaz:
https://doaj.org/article/31ea0b3839b944b18b727bc9dad40be2
Autor:
Otto M. Henriksen, María del Mar Álvarez-Torres, Patricia Figueiredo, Gilbert Hangel, Vera C. Keil, Ruben E. Nechifor, Frank Riemer, Kathleen M. Schmainda, Esther A. H. Warnert, Evita C. Wiegers, Thomas C. Booth
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ObjectiveSummarize evidence for use of advanced MRI techniques as monitoring biomarkers in the clinic, and highlight the latest bench-to-bedside developments.MethodsExperts in advanced MRI techniques applied to high-grade glioma treatment response as
Externí odkaz:
https://doaj.org/article/92abcec3fc364261b455198f2f070716