Výsledky vyhledávání - "Kathleen M, Bone"

Detection of chromosomal alteration after infusion of gene-edited allogeneic CAR T cells

Publikováno v: Molecular Therapy. 31:676-685

A chromosome 14 inversion was found in a patient who developed bone marrow aplasia following treatment with allogeneic chimeric antigen receptor (CAR) Tcells containing gene edits made with transcription activator-like effector nucleases (TALEN). TAL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacb87a6fa0b534085787ffd4e38c565
https://doi.org/10.1016/j.ymthe.2022.12.004

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A complex KMT2A::AFF3 fusion resulting from a three-way chromosomal rearrangement in pediatric B lymphoblastic leukemia

Autor: Lauren J. Miller, Vasiliki Leventaki, Paul D. Harker-Murray, Holli M. Drendel, Kathleen M. Bone

Publikováno v: Cancer genetics.

The KMT2A::AFF3 fusion, t(2;11)(q11.2;q23.2), is a very rare fusion occurring in pediatric B-cell acute lymphoblastic leukemia (B-ALL). Our patient is a 2-year-old male who presented with three weeks of intermittent fever. Bone marrow biopsy showed 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16e3138a103328eaac0507a239ac447
https://pubmed.ncbi.nlm.nih.gov/34995897

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Mosaic trisomy 1q: a recurring chromosome anomaly that is a diagnostic challenge and is associated with a Fryns-like phenotype

Autor: Ross McLeod, Mary Ann Thomas, Judy Chernos, Francois P. Bernier, Renee Perrier, A. Micheil Innes, Kathleen M. Bone

Publikováno v: Prenatal Diagnosis. 37:602-610

Objective Trisomy of the long arm of chromosome 1 is a very rare cytogenetic anomaly that is difficult to diagnose because of tissue-limited mosaicism. This study aimed to further characterize the prenatal and post-natal findings associated with this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54b778c762901d4f8b31c9301ba07aca
https://doi.org/10.1002/pd.5058

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Fusion Tyrosine Kinase NPM-ALK Deregulates MSH2 and Suppresses DNA Mismatch Repair Function

Autor: Benjamin Adam, Raymond Lai, Susan E. Andrew, Samar A. Hegazy, Fang Wu, Pascal Gelebart, Leah C. Young, Kathleen M. Bone, Jelena L. Holovati, Peng Wang, Liang Li

Publikováno v: The American Journal of Pathology. 179:411-421

The fusion tyrosine kinase NPM-ALK is central to the pathogenesis of ALK-positive anaplastic large cell lymphoma (ALK+ALCL). We recently identified that MSH2, a key DNA mismatch repair (MMR) protein integral to the suppression of tumorigenesis, is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44136d8e0113f457fd689934d2cd4576
https://doi.org/10.1016/j.ajpath.2011.03.045

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Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity

Autor: Joel D. Pearson, Peng Wang, Raymond Lai, Robert J. Ingham, Jingdong Zhang, Fang Wu, Karen Jung, Kathleen M. Bone, Xiaoxia Ye, Yupo Ma, Todd P. W. McMullen

Publikováno v: Cellular signalling. 24(11)

Sox2 (sex-determining region Y-box protein 2) is a transcription factor regulating pluripotency in embryonic stem cells. Sox2 is aberrantly expressed in breast and other cancers, though its biological significance remains widely unexplored. To unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f4af21b84612b2dbe3327385a0b441
https://pubmed.ncbi.nlm.nih.gov/22800865

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Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein

Autor: Leah C, Young, Kathleen M, Bone, Peng, Wang, Fang, Wu, Benjamin A, Adam, Samar, Hegazy, Pascal, Gelebart, Jelena, Holovati, Liang, Li, Susan E, Andrew, Raymond, Lai

Publikováno v: The American journal of pathology. 179(1)

The fusion tyrosine kinase NPM-ALK is central to the pathogenesis of ALK-positive anaplastic large cell lymphoma (ALK(+)ALCL). We recently identified that MSH2, a key DNA mismatch repair (MMR) protein integral to the suppression of tumorigenesis, is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15bace1985cd8e5f932f1b860adb1bb8
https://pubmed.ncbi.nlm.nih.gov/21703420

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NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair

Autor: Peng Wang, Susan E. Andrew, J T Bacani, Kathleen M. Bone, Liang Li, Chengsheng Wu, Fang Wu, Raymond Lai

Publikováno v: Blood Cancer Journal

The vast majority of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ALCL) tumors express the characteristic oncogenic fusion protein NPM-ALK, which mediates tumorigenesis by exerting its constitutive tyrosine kinase activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a82e4c06b58940f2c840e6814efab47
https://doi.org/10.1038/bcj.2015.35

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Aberrant expression and biological significance of Sox2, an embryonic stem cell transcriptional factor, in ALK-positive anaplastic large cell lymphoma

Autor: Pascal Gelebart, Joel D. Pearson, Mary M. Hitt, Peng Wang, Samar A. Hegazy, Robert J. Ingham, Yupo Ma, Kathleen M. Bone, David Sharon, Raymond Lai, Mona Anand

Publikováno v: Blood Cancer Journal

Sox2 (sex-determining region Y-Box) is one of the master transcriptional factors that are important in maintaining the pluripotency of embryonic stem cells (ESCs). In line with this function, Sox2 expression is largely restricted to ESCs and somatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ffe183223adbdbc2c2b5eee755745f
https://doi.org/10.1038/bcj.2012.27

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