Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kathleen L. McCann"'
Autor:
Katherine I. Farley-Barnes, Kathleen L. McCann, Lisa M. Ogawa, Janie Merkel, Yulia V. Surovtseva, Susan J. Baserga
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1923-1934 (2018)
Summary: Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain
Externí odkaz:
https://doaj.org/article/194e3efb6c77469099b14c40a7657e7e
Autor:
Jun Zhang, Kathleen L. McCann, Chen Qiu, Lauren E. Gonzalez, Susan J. Baserga, Traci M. Tanaka Hall
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nop9 is a conserved small ribosomal subunit biogenesis factor. Here, Zhang et al. show that Nop9, in complex with RNA, adopts a C-shaped fold formed from 11 Pumillo repeats and propose that Nop9 inhibits premature cleavage of 20S pre-rRNA by inhibiti
Externí odkaz:
https://doaj.org/article/faa28510bd764afbbb1cc91b25bbfcb8
Autor:
Evan Lester, Meaghan Van Alstyne, Kathleen L. McCann, Spoorthy Reddy, Li Yi Cheng, Jeff Kuo, James Pratt, Roy Parker
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Tau aggregates are a hallmark of multiple neurodegenerative diseases and can contain RNAs and RNA-binding proteins, including serine/arginine repetitive matrix protein 2 (SRRM2) and pinin (PNN). However, how these nuclear proteins mislocalize and the
Autor:
Evan Lester, Meaghan Van Alstyne, Kathleen L. McCann, Spoorthy Reddy, Li Yi Cheng, Jeff Kuo, James Pratt, Roy Parker
Tau aggregates are a hallmark of multiple neurodegenerative diseases and can contain RNAs and RNA binding proteins, including SRRM2 and PNN. How these resident nuclear proteins mislocalize and their influence on the prion-like propagation of tau fibe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cbdeb3fa4d928e8b302632584a1fc4d
https://doi.org/10.1101/2022.09.22.509111
https://doi.org/10.1101/2022.09.22.509111
Autor:
Sanam L Kavari, Traci M. Tanaka Hall, Adam B. Burkholder, Bart T. Phillips, Kathleen L. McCann
Publikováno v:
Nucleic Acids Res
H/ACA small nucleolar RNAs (snoRNAs) guide pseudouridylation as part of a small nucleolar ribonucleoprotein complex (snoRNP). Disruption of H/ACA snoRNA levels in stem cells impairs pluripotency, yet it remains unclear how H/ACA snoRNAs contribute to
Autor:
Vandita D Bhat, Marvin Wickens, Traci M. Tanaka Hall, Jacqueline C Alexander, Dallas R Fonseca, Zachary T. Campbell, Tarjani Shukla, Kathleen L. McCann, Te-Wen Lo, Chen Qiu, Yeming Wang
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
PUF (PUmilio/FBF) RNA-binding proteins recognize distinct elements. In C. elegans, PUF-8 binds to an 8-nt motif and restricts proliferation in the germline. Conversely, FBF-2 recognizes a 9-nt element and promotes mitosis. To understand how motif div
Autor:
Yulia V. Surovtseva, Kathleen I. Farley‐Barnes, Janie Merkel, Susan J. Baserga, Kathleen L. McCann, Lisa Ogawa
Publikováno v:
The FASEB Journal. 32
Publikováno v:
Genes & Development. 29:862-875
Maturation of the large ribosomal subunit (LSU) in eukaryotes is a complex and highly coordinated process that requires the concerted action of a large, dynamic, ribonucleoprotein complex, the LSU processome. While we know that >80 ribosome biogenesi
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
ANE syndrome is a ribosomopathy caused by a mutation in an RNA recognition motif of RBM28, a nucleolar protein conserved to yeast (Nop4). While patients with ANE syndrome have fewer mature ribosomes, it is unclear how this mutation disrupts ribosome