CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.

Autor: Nadia T Sebastian, Thomas D Zaikos, Valeri Terry, Frances Taschuk, Lucy A McNamara, Adewunmi Onafuwa-Nuga, Ryan Yucha, Robert A J Signer, James Riddell, Dale Bixby, Norman Markowitz, Sean J Morrison, Kathleen L Collins

Publikováno v: PLoS Pathogens, Vol 13, Iss 7, p e1006509 (2017)

Latent HIV infection of long-lived cells is a barrier to viral clearance. Hematopoietic stem and progenitor cells are a heterogeneous population of cells, some of which are long-lived. CXCR4-tropic HIVs infect a broad range of HSPC subtypes, includin

Externí odkaz: https://doaj.org/article/7587686bdff1460f9e8cbb0bac1907c0

Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes.

Autor: David R Collins, Jay Lubow, Zana Lukic, Michael Mashiba, Kathleen L Collins

Publikováno v: PLoS Pathogens, Vol 11, Iss 7, p e1005054 (2015)

Vpr is a conserved primate lentiviral protein that promotes infection of T lymphocytes in vivo by an unknown mechanism. Here we demonstrate that Vpr and its cellular co-factor, DCAF1, are necessary for efficient cell-to-cell spread of HIV-1 from macr

Externí odkaz: https://doaj.org/article/26d45abd8da046e6aa9758c1f90c54d2

HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.

Autor: Malinda R Schaefer, Elizabeth R Wonderlich, Jeremiah F Roeth, Jolie A Leonard, Kathleen L Collins

Publikováno v: PLoS Pathogens, Vol 4, Iss 8, p e1000131 (2008)

To facilitate viral infection and spread, HIV-1 Nef disrupts the surface expression of the viral receptor (CD4) and molecules capable of presenting HIV antigens to the immune system (MHC-I). To accomplish this, Nef binds to the cytoplasmic tails of b

Externí odkaz: https://doaj.org/article/dbc005e6b5204967ae6130d072de254e

Multi-omic single-cell velocity models epigenome–transcriptome interactions and improves cell fate prediction

Autor: Chen Li, Maria C. Virgilio, Kathleen L. Collins, Joshua D. Welch

Publikováno v: Nature Biotechnology. 41:387-398

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fb5882d20ec484e40c15047365ff5d1
https://doi.org/10.1038/s41587-022-01476-y

Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes

Autor: Jay Lubow, Andrew J Neevel, Kathleen L. Collins, Malini Raghavan, Megan McLeod, Ashootosh Tripathi, Xuefeng Ren, Andrew Robertson, David R. Collins, Jolie A. Leonard, David H. Sherman, Kirsten A Garcia, James H. Hurley, Alicja Piechocka-Trocha, Bruce D. Walker, Kay E. Leopold, Valeri H. Terry, Gretchen Zimmerman, Eli Olson, Lyanne Gomez-Rodriguez, Mark M. Painter, Madeline Merlino

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 38

Significance This study describes the discovery of a class of drug that can help the immune system eliminate hard-to-kill cells infected with HIV. HIV establishes a persistent infection for which there is no cure, necessitating the development of new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571d60c75d80cb16e3b05227ddf21b60
https://doi.org/10.1073/pnas.2008615117