Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kathleen Kokolus"'
Autor:
Shipra Gandhi, Mateusz Opyrchal, Melissa Grimm, Ronald Slomba, Kathleen Kokolus, Sebastiano Battaglia, Kristopher Attwood, Adrienne Groman, Lauren Williams, Mary Lynne Tarquini, Paul Wallace, Kah Teong Soh, Tracey O'Connor, Amy Early, Ellis Levine, Igor Puzanov, Marc Ernstoff, Pawel Kalinski
Publikováno v:
Cancer Research. 82:CT145-CT145
Background: Effective immune therapies depend on the presence of cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment (TME). Our preclinical data showed synergy between TLR3 ligands and interferon-α (IFN-α) in reprogramming the TME, but not
Autor:
Matthew Alexander, Kathleen Kokolus, Amanda Costa, Eleanor Clancy-Thompson, Elizabeth Repasky, David Mullins
Publikováno v:
The Journal of Immunology. 194:142.13-142.13
Recently it was reported that maintenance of mice at thermoneutral temperatures (TT, the temperature at which basal metabolism is sufficient to maintain body temperature, 30oC) enhanced antitumor immune responses and reduced tumor growth, relative to
Autor:
Kathleen Kokolus, Haley Spangler, Benjamin Povinelli, Matthew Farren, Kelvin Lee, Elizabeth Repasky
Publikováno v:
The Journal of Immunology. 192:71.20-71.20
The ability of dendritic cells (DC) to stimulate and regulate T cells is critical for effective anti-tumor immunity. Therefore, it is important to recognize any inherent factors which may influence DC function under experimental conditions, especiall
Autor:
Nicholas Leigh, Kathleen Kokolus, Jingxin Qiu, Philip. McCarthy, Xuefang Cao, Elizabeth Repasky
Publikováno v:
The Journal of Immunology. 192:202.26-202.26
Clinical bone marrow transplants (BMT) yield lethal graft vs. host disease (GVHD) after transplant of un-manipulated bone marrow (BM). This differs from murine GVHD models that typically require addition of spleen or lymph node derived T cells. Recen
Autor:
Kathleen Kokolus, Maegan Capitano, Chen-Ting Lee, Jason Eng, Bonnie Hylander, Jeremy Waight, Christopher Gordon, Scott Abrams, Elizabeth Repasky
Publikováno v:
The Journal of Immunology. 190:170.6-170.6
Laboratory mice are housed under relatively cool conditions and even though their core temperature remains normal, mice are cold stressed and exhibit significant increases in metabolic heat production. We compared tumor growth in mice housed at a sta