Supplementary Data from Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma

Autor: Christopher C. Oakes, Aharon G. Freud, Jonathan E. Brammer, Robert A. Baiocchi, Pierluigi Porcu, Anjali Mishra, Michael A. Caligiuri, Yasodha Natkunam, David M. Weinstock, Fabiola Valvert Gamboa, Emily M. Mace, John C. Reneau, Christoph Plass, Dieter Weichenhan, Thomas P. Loughran, Hernan Molina-Kirsch, Edward L. Briercheck, Carlos J. Suarez, Atif Saleem, Shan-Chi Yu, Carlos Barrionuevo, Daniela Dueñas, Daniel Y. Enriquez-Vera, Everardo Hegewisch-Solloa, Ekaterina Altynova, Matthew R. Lordo, Megan Broughton, Kevin G. Wu, Ansel P. Nalin, Kathleen K. McConnell, Karen A. Young, Gabrielle Ernst, Nicholas Polley, Susana Beceiro Casas, Youssef Youssef, Salma Abdelbaky, Yue-Zhong Wu, Christoph Weigel, Bethany L. Mundy-Bosse

Supplementary Data from Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03507e740bf228e7a9e19ab172022b32
https://doi.org/10.1158/2643-3230.22544069.v1

Data from Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma

Autor: Christopher C. Oakes, Aharon G. Freud, Jonathan E. Brammer, Robert A. Baiocchi, Pierluigi Porcu, Anjali Mishra, Michael A. Caligiuri, Yasodha Natkunam, David M. Weinstock, Fabiola Valvert Gamboa, Emily M. Mace, John C. Reneau, Christoph Plass, Dieter Weichenhan, Thomas P. Loughran, Hernan Molina-Kirsch, Edward L. Briercheck, Carlos J. Suarez, Atif Saleem, Shan-Chi Yu, Carlos Barrionuevo, Daniela Dueñas, Daniel Y. Enriquez-Vera, Everardo Hegewisch-Solloa, Ekaterina Altynova, Matthew R. Lordo, Megan Broughton, Kevin G. Wu, Ansel P. Nalin, Kathleen K. McConnell, Karen A. Young, Gabrielle Ernst, Nicholas Polley, Susana Beceiro Casas, Youssef Youssef, Salma Abdelbaky, Yue-Zhong Wu, Christoph Weigel, Bethany L. Mundy-Bosse

Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive, rare lymphoma of natural killer (NK) cell origin with poor clinical outcomes. Here we used phenotypic and molecular profiling, including epigenetic analyses, to investigate how ENKTL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c189c71003f69be17421be2c363d3ce
https://doi.org/10.1158/2643-3230.c.6550520.v1

Optimizing drug combinations for T-PLL: restoring DNA damage and P53-mediated apoptotic responses.

Autor: von Jan J; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Timonen S; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Braun T; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Jiang Q; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Department of Hematology, Cellular Therapy, Hemostaseology, Infectious Diseases, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig-Jena, Germany., Ianevski A; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Peng Y; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Department of Hematology, Cellular Therapy, Hemostaseology, Infectious Diseases, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig-Jena, Germany., McConnell K; Thomas Jefferson University, Philadelphia, PA., Sindaco P; Thomas Jefferson University, Philadelphia, PA., Müller TA; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Pützer S; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Klepzig H; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Jungherz D; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Department of Hematology, Cellular Therapy, Hemostaseology, Infectious Diseases, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig-Jena, Germany., Dechow A; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Wahnschaffe L; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Giri AK; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Kankainen M; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland., Kuusanmäki H; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Neubauer HA; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria., Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna, Austria., Mazzeo P; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany.; Clinics of Hematology and Medical Oncology, INDIGHO Laboratory, University Medical Center Göttingen, Göttingen, Germany., Schmidt N; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Koch R; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Hallek M; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Chebel A; Lymphoma Immuno Biology Team, Equipe Labellisée LIGUE 2023, Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Faculté de Médecine Lyon-Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon I-ENS de Lyon, Lyon, France., Armisen D; Lymphoma Immuno Biology Team, Equipe Labellisée LIGUE 2023, Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Faculté de Médecine Lyon-Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon I-ENS de Lyon, Lyon, France., Genestier L; Lymphoma Immuno Biology Team, Equipe Labellisée LIGUE 2023, Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Faculté de Médecine Lyon-Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon I-ENS de Lyon, Lyon, France., Bachy E; Lymphoma Immuno Biology Team, Equipe Labellisée LIGUE 2023, Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Faculté de Médecine Lyon-Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon I-ENS de Lyon, Lyon, France., Mishra A; Thomas Jefferson University, Philadelphia, PA.; Sidney Kimmel Cancer Center, Philadelphia, PA., Schrader A; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Lymphoma Immuno Biology Team, Equipe Labellisée LIGUE 2023, Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Faculté de Médecine Lyon-Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon I-ENS de Lyon, Lyon, France., Aittokallio T; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway.; ICAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Mustjoki S; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; ICAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Herling M; Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Department of Hematology, Cellular Therapy, Hemostaseology, Infectious Diseases, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.; Comprehensive Cancer Center Central Germany, Leipzig-Jena, Germany.

Publikováno v: Blood [Blood] 2024 Oct 10; Vol. 144 (15), pp. 1595-1610.

Preclinical evaluation of anti-CD38 therapy in mature T-cell neoplasms.

Autor: Isabelle C; Sidney Kimmel Cancer Center, Division of Hematologic Malignancies, Thomas Jefferson University, Philadelphia, PA., Johnson WT; Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY., McConnell K; Sidney Kimmel Cancer Center, Division of Hematologic Malignancies, Thomas Jefferson University, Philadelphia, PA., Vogel A; Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA., Brammer JE; Division of Hematology, Department of Internal Medicine, The James Comprehensive Center, The Ohio State University, Columbus, OH., Boles A; Sidney Kimmel Cancer Center, Division of Hematologic Malignancies, Thomas Jefferson University, Philadelphia, PA., Keller R; Sidney Kimmel Cancer Center, Division of Hematologic Malignancies, Thomas Jefferson University, Philadelphia, PA., Sindaco P; Sidney Kimmel Cancer Center, Division of Hematologic Malignancies, Thomas Jefferson University, Philadelphia, PA., Nisenfeld L; Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA., Uppal G; Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA., Nikbakht N; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA., Calabretta B; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA., Porazzi P; Division of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Center for Cellular Immunotherapies, Division of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Gong J; Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA., Chakravarti N; Sidney Kimmel Cancer Center, Division of Hematologic Malignancies, Thomas Jefferson University, Philadelphia, PA., Porcu P; Sidney Kimmel Cancer Center, Division of Hematologic Malignancies, Thomas Jefferson University, Philadelphia, PA., Mishra A; Sidney Kimmel Cancer Center, Division of Hematologic Malignancies, Thomas Jefferson University, Philadelphia, PA.; Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA.

Publikováno v: Blood advances [Blood Adv] 2023 Jul 25; Vol. 7 (14), pp. 3637-3641.

Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function.

Autor: Scoville SD; Medical Scientist Training Program.; Comprehensive Cancer Center., Nalin AP; Medical Scientist Training Program.; Comprehensive Cancer Center., Chen L; Medical Scientist Training Program.; Comprehensive Cancer Center., Chen L; Comprehensive Cancer Center., Zhang MH; Comprehensive Cancer Center., McConnell K; Comprehensive Cancer Center., Beceiro Casas S; Comprehensive Cancer Center., Ernst G; Comprehensive Cancer Center., Traboulsi AA; Comprehensive Cancer Center., Hashi N; Comprehensive Cancer Center., Williams M; Comprehensive Cancer Center., Zhang X; Center for Biostatistics., Hughes T; Comprehensive Cancer Center.; Division of Hematology, Department of Internal Medicine., Mishra A; Comprehensive Cancer Center.; Division of Dermatology, Department of Internal Medicine, and., Benson DM; Comprehensive Cancer Center.; Division of Hematology, Department of Internal Medicine., Saultz JN; Comprehensive Cancer Center.; Division of Hematology, Department of Internal Medicine., Yu J; Comprehensive Cancer Center.; Division of Hematology, Department of Internal Medicine., Freud AG; Comprehensive Cancer Center.; Department of Pathology, The Ohio State University, Columbus, OH; and., Caligiuri MA; Division of Hematology, City of Hope National Cancer Center, Duarte, CA., Mundy-Bosse BL; Comprehensive Cancer Center.; Division of Hematology, Department of Internal Medicine.

Publikováno v: Blood [Blood] 2018 Oct 25; Vol. 132 (17), pp. 1792-1804. Date of Electronic Publication: 2018 Aug 29.