Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kathleen Köck"'
Publikováno v:
Biopharmaceutics & Drug Disposition. 38:251-259
Natural products, including botanical dietary supplements and exotic drinks, represent an ever-increasing share of the health-care market. The parallel ever-increasing popularity of self-medicating with natural products increases the likelihood of co
Publikováno v:
Drug Metabolism and Disposition. 43:725-734
Drug-induced liver injury (DILI) is an important cause of drug toxicity. Inhibition of multidrug resistance protein 4 (MRP4), in addition to bile salt export pump (BSEP), might be a risk factor for the development of cholestatic DILI. Recently, we de
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 353:415-423
The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the relative contributions of biliary (CLBile) versus basolateral effl
Autor:
Sabina Buntich, Amber Umble-Romero, Wei-Jian Pan, L Som, Jason M. Gow, C D Krill, Yu Sun, Samantha P. Prokop, Kathleen Köck, Alexander Colbert, Yu Zhang, Wayne Tsuji, Jennifer E. Towne, T J Goletz, M W Trimble, William A. Rees, John P. Gibbs, Michelle Horner, J C O'Neill, Kathryn J. Newhall
Publikováno v:
British Journal of Pharmacology. 172:159-172
Background and Purpose AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to deter
Autor:
Anthony M. Treacy, Virginia M Platt, Christine M. Evangelista, Dominic C. Borie, Lynn Smith, Mark Yen, Jane M. Andrews, Peter J. Prince, Kefei Zhou, Wei-Jian Pan, Christine D Krill, Graham L. Radford-Smith, Jason M. Gow, Kaz O Reynhardt, Jonathan Lee, Zhigang Yu, David R. Doherty, Kathleen Köck, William A. Rees, Barbara A. Sullivan, Sonal K. Patel, Jing Jing Shen
Publikováno v:
British Journal of Clinical Pharmacology. 78:1315-1333
AIMS AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration were evaluated in a randomized, double-blind, placebo-controlled study. METHODS Healthy mal
Autor:
Taleah Farasyn, Kathleen Köck, Sonia Pahwa, John L. Powell, Xiaojie Meng, Kim L. R. Brouwer, Wei Yue
Publikováno v:
Drug Metabolism and Disposition. 42:1964-1970
The organic anion-transporting polypeptide (OATP) 1B3 is a membrane transport protein that mediates hepatic uptake of many drugs and endogenous compounds. Currently, determination of OATP-mediated drug-drug interactions in vitro is focused primarily
Autor:
Ajay Nirula, Megan A. Gibbs, Marc R. Gastonguay, David Martin, Kathleen Köck, David H. Salinger, Paul Klekotka, Endres Christopher J
Publikováno v:
The Journal of Clinical Pharmacology. 54:1230-1238
Brodalumab, a human monoclonal IgG2-antibody, acts as a potent antagonist at the interleukin-17 receptor A, which is important in the pathogenesis of psoriasis. To characterize the pharmacokinetics of brodalumab and assess the effects of covariates,
Autor:
Brian C. Ferslew, Thomas J. Urban, Peter W. Swaan, Kathleen Köck, Kim L. R. Brouwer, Ida Netterberg, Paul W. Stewart, Kyunghee Yang
Publikováno v:
Drug Metabolism and Disposition. 42:665-674
Impaired hepatic bile acid export may contribute to development of cholestatic drug-induced liver injury (DILI). The multidrug resistance-associated proteins (MRP) 3 and 4 are postulated to be compensatory hepatic basolateral bile acid efflux transpo
Publikováno v:
Journal of Pharmaceutical Sciences. 102:3037-3057
Drug-induced cholestasis is an important form of acquired liver disease and is associated with significant morbidity and mortality. Bile acids are key signaling molecules, but they can exert toxic responses when they accumulate in hepatocytes. This r
Publikováno v:
Biopharmaceuticsdrug disposition. 38(3)
Natural products, including botanical dietary supplements and exotic drinks, represent an ever-increasing share of the health care market. The parallel ever-increasing popularity of self-medicating with natural products increases the likelihood of co