Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Kathleen J Millen"'
Autor:
Branden R Nelson, Rebecca D Hodge, Ray AM Daza, Prem Prakash Tripathi, Sebastian J Arnold, Kathleen J Millen, Robert F Hevner
Publikováno v:
eLife, Vol 9 (2020)
The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages
Externí odkaz:
https://doaj.org/article/f6a9cc73f49c42e5945cb98f7ba78864
Autor:
Achira Roy, Rory M Murphy, Mei Deng, James W MacDonald, Theo K Bammler, Kimberly A Aldinger, Ian A Glass, Kathleen J Millen
Publikováno v:
eLife, Vol 8 (2019)
Mechanisms driving the initiation of brain folding are incompletely understood. We have previously characterized mouse models recapitulating human PIK3CA-related brain overgrowth, epilepsy, dysplastic gyrification and hydrocephalus (Roy et al., 2015)
Externí odkaz:
https://doaj.org/article/733e86e1d51148799cd6159aaf11757b
Autor:
Parthiv Haldipur, Derek Dang, Kimberly A Aldinger, Olivia K Janson, Fabien Guimiot, Homa Adle-Biasette, William B Dobyns, Joseph R Siebert, Rosa Russo, Kathleen J Millen
Publikováno v:
eLife, Vol 6 (2017)
FOXC1 loss contributes to Dandy-Walker malformation (DWM), a common human cerebellar malformation. Previously, we found that complete Foxc1 loss leads to aberrations in proliferation, neuronal differentiation and migration in the embryonic mouse cere
Externí odkaz:
https://doaj.org/article/08a5168aebb147bb89ad289933a1214c
Autor:
Achira Roy, Jonathan Skibo, Franck Kalume, Jing Ni, Sherri Rankin, Yiling Lu, William B Dobyns, Gordon B Mills, Jean J Zhao, Suzanne J Baker, Kathleen J Millen
Publikováno v:
eLife, Vol 4 (2015)
Mutations in the catalytic subunit of phosphoinositide 3-kinase (PIK3CA) and other PI3K-AKT pathway components have been associated with cancer and a wide spectrum of brain and body overgrowth. In the brain, the phenotypic spectrum of PIK3CA-related
Externí odkaz:
https://doaj.org/article/8b73c5ef06e44f5fb30f8bcd73579e05
Autor:
Parthiv Haldipur, Gwendolyn S Gillies, Olivia K Janson, Victor V Chizhikov, Divakar S Mithal, Richard J Miller, Kathleen J Millen
Publikováno v:
eLife, Vol 3 (2014)
Loss of Foxc1 is associated with Dandy-Walker malformation, the most common human cerebellar malformation characterized by cerebellar hypoplasia and an enlarged posterior fossa and fourth ventricle. Although expressed in the mouse posterior fossa mes
Externí odkaz:
https://doaj.org/article/6dc0ae03148e442297b9205442a87a09
Autor:
Parthiv Haldipur, Kathleen J Millen
Publikováno v:
eLife, Vol 2 (2013)
Long predicted from studies of model vertebrates, the first human example of abnormal patterning of the early neural tube leading to underdevelopment of the cerebellum has been demonstrated.
Externí odkaz:
https://doaj.org/article/8f1e1a7f1b6d414a8c5d393c40b0c563
Autor:
Jessica A Lehoczky, Peedikayil E Thomas, Kevin M Patrie, Kailey M Owens, Lisa M Villarreal, Kenneth Galbraith, Joe Washburn, Craig N Johnson, Bryant Gavino, Alexander D Borowsky, Kathleen J Millen, Paul Wakenight, William Law, Margaret L Van Keuren, Galina Gavrilina, Elizabeth D Hughes, Thomas L Saunders, Lesil Brihn, Joseph H Nadeau, Jeffrey W Innis
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003967 (2013)
Mouse early transposon insertions are responsible for ~10% of spontaneous mutant phenotypes. We previously reported the phenotypes and genetic mapping of Polypodia, (Ppd), a spontaneous, X-linked dominant mutation with profound effects on body plan m
Externí odkaz:
https://doaj.org/article/7e2168f239154d7b8e91247117543900
Autor:
Samin A Sajan, Liliana Fernandez, Sahar Esmaeeli Nieh, Eric Rider, Polina Bukshpun, Mari Wakahiro, Susan L Christian, Jean-Baptiste Rivière, Christopher T Sullivan, Jyotsna Sudi, Michael J Herriges, Alexander R Paciorkowski, A James Barkovich, Joseph T Glessner, Kathleen J Millen, Hakon Hakonarson, William B Dobyns, Elliott H Sherr
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003823 (2013)
Agenesis of the corpus callosum (ACC), cerebellar hypoplasia (CBLH), and polymicrogyria (PMG) are severe congenital brain malformations with largely undiscovered causes. We conducted a large-scale chromosomal copy number variation (CNV) discovery eff
Externí odkaz:
https://doaj.org/article/38bc6373d53e49c3b54ea00de1a412d8
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 11, p e1000559 (2009)
We have generated and made publicly available two very large networks of molecular interactions: 49,493 mouse-specific and 52,518 human-specific interactions. These networks were generated through automated analysis of 368,331 full-text research arti
Externí odkaz:
https://doaj.org/article/f5e143fd80564506acf5526e8202cbbc
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4729 (2009)
Outbred laboratory mouse populations are widely used in biomedical research. Since little is known about the degree of genetic variation present in these populations, they are not widely used for genetic studies. Commercially available outbred CD-1 m
Externí odkaz:
https://doaj.org/article/5cbf4eb7bf774d5f8c59902fe3d765bb