Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Kathleen J Millen"'
Autor:
Amanda J. Stock, Pierina Gonzalez Paredes, Luciana Previato de Almeida, Stanley D. Kosanke, Srinivaas Chetlur, Hannah Budde, Paul Wakenight, Theresa A. Zwingman, Aaron B.I. Rosen, Eric J. Allenspach, Kathleen J. Millen, Jane H. Buckner, David J. Rawlings, Jacquelyn A. Gorman
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic islet β-cells are attacked by the immune system, resulting in insulin deficiency and hyperglycemia. One of the top non-synonymous single-nucleotide polymorphisms (SNP) associated wit
Externí odkaz:
https://doaj.org/article/348e199e09ab4f3484da495fb0461ba0
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Over the past decade, survival rates for extremely low gestational age neonates (ELGANs;
Externí odkaz:
https://doaj.org/article/05499f46b541495e9d7b2072d81ac7c9
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Chronic epilepsy has been associated with hippocampal abnormalities like neuronal loss, gliosis and granule cell dispersion. The granule cell layer of a normal human hippocampal dentate gyrus is traditionally regarded as a compact neuron-den
Externí odkaz:
https://doaj.org/article/59bf50a197f945b194e1c1f94f400a5a
Autor:
Daryl M. Okamura, Chris M. Brewer, Paul Wakenight, Nadia Bahrami, Kristina Bernardi, Amy Tran, Jill Olson, Xiaogang Shi, Szu-Ying Yeh, Adrian Piliponsky, Sarah J. Collins, Elizabeth D. Nguyen, Andrew E. Timms, James W. MacDonald, Theo K. Bammler, Branden R. Nelson, Kathleen J. Millen, David R. Beier, Mark W. Majesky
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103269- (2021)
Summary: Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. Whether spiny mice also regenerate internal orga
Externí odkaz:
https://doaj.org/article/14339f301a224e7fbcad8ed0416f3953
Autor:
Achira Roy, Victor Z. Han, Angela M. Bard, Devin T. Wehle, Stephen E. P. Smith, Jan-Marino Ramirez, Franck Kalume, Kathleen J. Millen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Patients harboring mutations in the PI3K-AKT-MTOR pathway-encoding genes often develop a spectrum of neurodevelopmental disorders including epilepsy. A significant proportion remains unresponsive to conventional anti-seizure medications. Understandin
Externí odkaz:
https://doaj.org/article/2d9e75212ff44739a7d5a2363a17616b
Autor:
Victor V. Chizhikov, Igor Y. Iskusnykh, Ekaterina Y. Steshina, Nikolai Fattakhov, Anne G. Lindgren, Ashwin S. Shetty, Achira Roy, Shubha Tole, Kathleen J. Millen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The contribution of long-range signaling to cortical gyrification remains poorly understood. In this study, authors demonstrate that the combined genetic loss of transcription factors Lmx1a and Lmx1b, expressed in the telencephalic dorsal midline neu
Externí odkaz:
https://doaj.org/article/5e9a3cae7cdf4bcbae7688176c6be113
Autor:
Branden R Nelson, Rebecca D Hodge, Ray AM Daza, Prem Prakash Tripathi, Sebastian J Arnold, Kathleen J Millen, Robert F Hevner
Publikováno v:
eLife, Vol 9 (2020)
The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages
Externí odkaz:
https://doaj.org/article/f6a9cc73f49c42e5945cb98f7ba78864
Autor:
Aguan D, Wei, Paul, Wakenight, Theresa A, Zwingman, Angela M, Bard, Nikhil, Sahai, Marjolein H, Willemsen, Helenius J, Schelhaas, Alexander P A, Stegmann, Judith S, Verhoeven, Stella A, de Man, Marja W, Wessels, Tjitske, Kleefstra, Deepali N, Shinde, Katherine L, Helbig, Alice, Basinger, Victoria F, Wagner, David, Rodriguez-Buritica, Emily, Bryant, John J, Millichap, Kathleen J, Millen, William B, Dobyns, Jan-Marino, Ramirez, Franck K, Kalume
Publikováno v:
J Neurophysiol
We identified six novel de novo human KCNQ5 variants in children with motor/language delay, intellectual disability (ID), and/or epilepsy by whole exome sequencing. These variants, comprising two nonsense and four missense alterations, were functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7bb22d128da88c1a4a5199219f0c020e
https://pubmed.ncbi.nlm.nih.gov/35583973
https://pubmed.ncbi.nlm.nih.gov/35583973
Publikováno v:
Annual Review of Neuroscience. 45:515-531
Developmental abnormalities of the cerebellum are among the most recognized structural brain malformations in human prenatal imaging. Yet reliable information regarding their cause in humans is sparse, and few outcome studies are available to inform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9391f540db518c3bcde1f3734cd79abf
https://doi.org/10.1146/annurev-neuro-111020-091953
https://doi.org/10.1146/annurev-neuro-111020-091953
Autor:
Aguan D. Wei, Paul Wakenight, Theresa A. Zwingman, Angela M. Bard, Nikhil Sahai, Marjolein H. Willemsen, Helenius J. Schelhaas, Alexander P. A. Stegmann, Judith S. Verhoeven, Stella A. de Man, Marja W. Wessels, Tjitske Kleefstra, Deepali N. Shinde, Katherine L. Helbig, Alice Basinger, Victoria F. Wagner, David Rodriguez-Buritica, Emily Bryant, John J. Millichap, Kathleen J. Millen, William B. Dobyns, Jan-Marino Ramirez, Franck K. Kalume
Publikováno v:
Journal of Neurophysiology, 128(1), 40-61. American Physiological Society
Journal of Neurophysiology, 128, 40-61
Journal of Neurophysiology, 128, 1, pp. 40-61
Journal of Neurophysiology, 128, 40-61
Journal of Neurophysiology, 128, 1, pp. 40-61
We identified six novel de novo human KCNQ5 variants in children with motor/language delay, intellectual disability (ID), and/or epilepsy by whole exome sequencing. These variants, comprising two nonsense and four missense alterations, were functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642861c243e1b13561f237e928630bf1
https://doi.org/10.1152/jn.00509.2021
https://doi.org/10.1152/jn.00509.2021